DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uggt and UGGT2

DIOPT Version :9

Sequence 1:	NP_524151.2	Gene:	Uggt / 40055	FlyBaseID:	FBgn0014075	Length:	1548	Species:	Drosophila melanogaster
Sequence 2:	XP_011519396.1	Gene:	UGGT2 / 55757	HGNCID:	15664	Length:	1590	Species:	Homo sapiens

Alignment Length:	1566	Identity:	628/1566 - (40%)
Similarity:	924/1566 - (59%)	Gaps:	95/1566 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKLDTVLNEYDTESQQYNA 85
            ||..:.|..:|..:.|||.:|||.||.:|::|:|....||.::..|.:| .:..:.:::...||.
Human    26 SGTVAASKSVTAHLAAKWPETPLLLEASEFMAEESNEKFWQFLETVQEL-AIYKQTESDYSYYNL 89

  Fly    86 ALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQSFTFAQVGSELACSFNEL 150
            .|:.....:.:..:.||:...|:.:.:|.||...|:|.:......|.:|..  :..:..|..||:
Human    90 ILKKAGQFLDNLHINLLKFAFSIRAYSPAIQMFQQIAADEPPPDGCNAFVV--IHKKHTCKINEI 152

  Fly   151 QKKLEVPLAKDSLDASVVTYSF--DHIFPGSENNTRTVVLYGDLGSSQFRTYHKLLEKEANAGRI 213
            :|.|:...::..      .|.|  ||.||.::.|...|:||.::|:..|..:||:|.::|....|
Human   153 KKLLKKAASRTR------PYLFKGDHKFPTNKENLPVVILYAEMGTRTFSAFHKVLSEKAQNEEI 211

  Fly   214 RYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGSTSDEDLANESDVQGFDFKVL 278
            .|:|||.:.|...|.:.||||||||.:||||||:.||.......:|:.||....::||||.|..|
Human   212 LYVLRHYIQKPSSRKMYLSGYGVELAIKSTEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKL 276

  Fly   279 KQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAAAIAEIQGDETLQILQYTAHNFPM 343
            |:.:..|:..|...::.|::.|.::..||.||.|||..|||:.|......:::::::..:.|||:
Human   277 KEIYSDLRDNLTAFQKYLIESNKQMMPLKVWELQDLSFQAASQIMSAPVYDSIKLMKDISQNFPI 341

  Fly   344 LARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTMDLYSLIETLRSEMRV 408
            .||:|....|...:|.|:|.|.:.......:.|.|..||||||..|.|..|.:|:::.|:.|.::
Human   342 KARSLTRIAVNQHMREEIKENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKM 406

  Fly   409 LESLHSNNVRGSLASSLLALDLTASSKKEFAIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPT 473
            :..|.:..:.|...|..|.|: :...:..:.:|||.:::.|:||:|||..|..||:|...||:|.
Human   407 MNGLRNLGINGEDMSKFLKLN-SHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPV 470

  Fly   474 FPGMLRNIRKNVFNLVLVVDALQPTARSVIKLSESFVIHQAPIRLGLVFDARDANE-DNLADY-V 536
            |||.:.:||:|..||||.:|..|......|||::.|..|:.|:|:|.||.....:| |...|. |
Human   471 FPGSVPSIRRNFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAGV 535

  Fly   537 AITCAYNYVSQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQLTKEFTSLSFAKAEEFLEEDST 601
            |:..|:||::::.|...|...:..:|..|.:.:.:...|.||.:.:  .:...|...:.|...|.
Human   536 ALWRAFNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQ--NTFPHANIWDILGIHSK 598

  Fly   602 YDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEEAIFTEIMTHTSNLQKAVYKG 666
            ||..|:..|.|.:..|.|.  .||||.||.|.....:.. .:.:.|:...:|..:..||:.|:.|
Human   599 YDEERKAGASFYKMTGLGP--LPQALYNGEPFKHEEMNI-KELKMAVLQRMMDASVYLQREVFLG 660

  Fly   667 ELTDNDVAIDYLMNQPHVMPRLNQRILSQEDVKYLD-INGVAYKNLGNVGVLNRLSNRDMTATLM 730
            .|.|...|||:||::.:|:||:|..|| :.:.:||: |:.....::.:......|.::|.:|.:.
Human   661 TLNDRTNAIDFLMDRNNVVPRINTLIL-RTNQQYLNLISTSVTADVEDFSTFFFLDSQDKSAVIA 724

  Fly   731 DNLKYFGGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHALDYVQSGESVRVAFIPNTESSS 795
            .|:.|.  .:..|.|    :..:|:|:.||.:...||.||.:||.::::....|:..|.|..|..
Human   725 KNMYYL--TQDDESI----ISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPTSKI 783

  Fly   796 ASSRRNLNRLVWAAMQSLPPTQATEQVLKWL-KKPKEKI--------EIPTQLEDILGSTELHLK 851
            ......::|.:.||..    ||....:..:| :..||:|        :|.|.|.:.:.......|
Human   784 NEENTAISRGILAAFL----TQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNAFEKK 844

  Fly   852 MLRV----------YSQRVLGLNKSQRLVIGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKV 906
            ...|          :.|.||.|...:..::.|||..|||  ||.|.:.||.||.:.:.....:|:
Human   845 YNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPL--DEDFYAEDFYLLEKITFSNLGEKI 907

  Fly   907 RQVLKESAQDVNEEFNSDTLLKLYA--SLLPRQTKTRFKLPTDLKTDHSVVKLPPKQENLPHFDV 969
            :.:::.  ..:|....||.::|:.|  |.:|::. :|:.: |.|:.:|||:|..| |||...|:|
Human   908 KGIVEN--MGINANNMSDFIMKVDALMSSVPKRA-SRYDV-TFLRENHSVIKTNP-QENDMFFNV 967

  Fly   970 AAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVK-------------------- 1014
            .|::||.:|.|||:..:|::|.:::|.::.|::....:.|:.|::
Human   968 IAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLERITVIHYEPFLLMGIFSSPS 1032

  Fly  1015 -------NFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLD 1072
                   .|||:|:|||:...||...|.||:|||..:|.:|||...:..||.||||.|.:..|||
Human  1033 CVIGQKTGFYRFVLEPELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLD 1097

  Fly  1073 NIKLTDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMANLGYFQLK 1137
            ||.|.|....|.:|::||||||||.|||..:..||||||..|||:::|.:|||||||:.||||||
Human  1098 NIHLKDTEKTVTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLK 1162

  Fly  1138 ANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAEL 1202
            ||||||.|||.:|||.|||.|...|||::  .|...::.|::.|.:|.::|::|.|:....:.::
Human  1163 ANPGAWILRLHQGKSEDIYQIVGHEGTDS--QADLEDIIVVLNSFKSKILKVKVKKETDKIKEDI 1225

  Fly  1203 LSDDNEQAAQSGMWNSIASSFGGGSANQAATDEDTETINIFSVASGHLYERLLRIMMVSLLKHTK 1267
            |:|::|:.  .|:|:|| .||......:...::|  .:|||||||||||||.|||||:|:|::||
Human  1226 LTDEDEKT--KGLWDSI-KSFTVSLHKENKKEKD--VLNIFSVASGHLYERFLRIMMLSVLRNTK 1285

  Fly  1268 SPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFP 1332
            :|||||.|||||||.|.:.:||||.||.|:||||||:|||||.||||:||.||||||||||||||
Human  1286 TPVKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDVLFP 1350

  Fly  1333 LNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYH 1397
            |.|.||||||||.|||.|:|||.|.||.||||.||||||||:||:|:||||.|||.|||:.|:||
Human  1351 LAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLLRRKYH 1415

  Fly  1398 ISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTW 1462
            ||||||||||:||:|.||||||.||||||||||||||||||||||||:||||||||.|||||:||
Human  1416 ISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAIKSLPQDWLWCETW 1480

  Fly  1463 CSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIED--HENSHSRDSAVD 1525
            |.|.:.:.||.|||||||:|||:||.||.||||||.:||||::.|:..:|:  .:.|.:|..|..
Human  1481 CDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLDHLENKKQDTSSTRSMAAS 1545

  Fly  1526 DSVDDS 1531
            .|.:.|
Human  1546 ASGEAS 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	UDP-g_GGTase	29..1196	CDD:283964	401/1219 (33%)
		RfaJ	1238..>1456	CDD:224359	172/217 (79%)
		GT8_HUGT1_C_like	1240..1487	CDD:133054	193/246 (78%)
UGGT2	XP_011519396.1	UDP-g_GGTase	33..1216	CDD:283964	400/1217 (33%)
UGGT2	XP_011519396.1	GT8_HUGT1_C_like	1258..1505	CDD:133054	193/246 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160068
Domainoid	1	1.000	472	1.000	Domainoid score	I451
eggNOG	1	0.900	-	-		E1_KOG1879
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1229	1.000	Inparanoid score	I187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55769
OrthoDB	1	1.010	-	-		D231263at2759
OrthoFinder	1	1.000	-	-		FOG0002023
OrthoInspector	1	1.000	-	-		otm40632
orthoMCL	1	0.900	-	-		OOG6_101176
Panther	1	1.100	-	-	LDO	PTHR11226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2174
SonicParanoid	1	1.000	-	-		X1498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800