Protein Alignment Uggt and Uggt1

DIOPT Version :10

• Sequence 1: NP_524151.2
• Gene: Uggt / 40055
• FlyBaseID: FBgn0014075
• Length: 1548
• Species: Drosophila melanogaster
• Sequence 2: NP_942602.2
• Gene: Uggt1 / 320011
• MGIID: 2443162
• Length: 1551
• Species: Mus musculus
• Alignment Length: 1577
• Identity: 689/1577 - (43%)
• Similarity: 967/1577 - (61%)
• Gaps: 92/1577 - (5%)

  Fly    12 VLIALYTPT--SGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKLDTVLN 74
            :||||..|.  |...:.|..|||.:..||...||.||.:|:||::....||.:|.....:.: .:
Mouse    27 LLIALALPCLFSLAEANSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEATQNIGS-SD 90

  Fly    75 EYDTESQQYNAALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQSFTFAQV 139
            .:||:...|:|.||.....:|..|..||:..:|:.|.:..||...|:|.:......|:|  |..|
Mouse    91 HHDTDHSYYDAVLEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKS--FLSV 153

  Fly   140 GSELACSFNELQKKLEVPLAKDSLDASVVTYSFDHIFPGSENNTRTVVLYGDLGSSQFRTYHKLL 204
            ..:..|..:.|:..|..  |.|.  ...:.:..||.:|.|...:..|:||.::|..:|...|..|
Mouse   154 HGKQTCDLDTLESLLLT--AADR--PKPLLFKGDHRYPSSNPESPVVILYSEIGHEEFSNIHHQL 214

  Fly   205 EKEANAGRIRYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGSTSDEDLANESD 269
            ..::|.|:|.|:.||.::...|.||.||||||||.:||||||::||.  ...|:..:..:..|||
Mouse   215 ISKSNEGKINYVFRHYISNPSKEPVYLSGYGVELAIKSTEYKAKDDT--QVKGTEVNATVIGESD 277

  Fly   270 ----VQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAAAIAEIQGDET 330
                ||||.|..|::.:|.|:..|.:.|:.|::..:|:|.||.|:.|||..|.||.|....|..:
Mouse   278 PIDEVQGFLFGKLRELYPALEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAASGALS 342

  Fly   331 LQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTMDL 395
            |.:::..:.|||..||.:....|:..|||||:.|.:.|..::.:.|.|.|||||||..|.||.|:
Mouse   343 LVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDI 407

  Fly   396 YSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKKEFAIDIRDTAVQWVNDIENDVQYR 460
            :||.:|||:|.||:|.||...:.|....::|.|:: ..|:.::|:|||..|:.|||::|.|.:|.
Mouse   408 FSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNI-QPSETDYAVDIRSPAISWVNNLEVDSRYN 471

  Fly   461 RWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVIKLSESFVIHQAPIRLGLVFDAR 525
            .||||:.:||||||||::|.||||:.|:|.::|.:..|...:|.::|.|:.:..|:|:|.:|...
Mouse   472 SWPSSLQELLRPTFPGVIRQIRKNLHNMVFIIDPVHETTAELISIAEMFLSNHIPLRIGFIFVVN 536

  Fly   526 DANE-DNLADY-VAITCAYNYVSQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQLTKEFTSLS 588
            |:.: |.:.|. ||:..|||||:|:.|...|...||.||..|...:.|..:.:|..|.|::   .
Mouse   537 DSEDVDGMQDAGVAVLRAYNYVAQEVDGYHAFQTLTQIYNKVRTGETVKVEHVVSVLEKKY---P 598

  Fly   589 FAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEEAIFTEIM 653
            :.:....|..||.||..|:.|..:.::.|.|.  .|..|.||:|.....:..| :.|.....:|:
Mouse   599 YVEVNSILGIDSAYDQNRKEARGYYEQTGVGP--LPVVLFNGMPFEKEQLDPD-ELETITMHKIL 660

  Fly   654 THTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQEDVKYLDINGVAYKNLGNVGVLN 718
            ..|:..|:|||.|||:.:...::|:||||:|:||:|.|||:.:. :|||:.......:.:....:
Mouse   661 ETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKR-EYLDLTASNNFYVDDFARFS 724

  Fly   719 RLSNRDMTATLMDNLKYF--GGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHALDYVQSGE 781
            .|.:|..||.:.:::.|.  .|..|.|:...:.::.:|.|:..|.::..||.||..|:.:.::..
Mouse   725 ALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSN 789

  Fly   782 SVRVAFIPNTESSSASSRRNLNRLVWAAMQSLPPTQATEQVLKWLKKPKEK-----IEIP----- 836
            :||::.|.|.....:.|...:.|.:|||:|:...:.|...:.|..|:...:     ::|.
Mouse   790 NVRISMINNPSQEISDSSTPIFRAIWAALQTQASSSAKNFITKMAKEETAEALAAGVDIAEFSVG 854

  Fly   837 ----TQLEDILGSTELHLKMLR-VYSQRVLGLNKSQRLVIGNGRLYGPLSSDESFDSADFALLAR 896
                :..:::..|:.:...:.. :|.:.||.|.|.||:||.|||:.|||..:|.|:..||.||..
Mouse   855 GMDVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDNELFNQDDFHLLEN 919

  Fly   897 FSSLQYSDKVRQVLKESAQD---------VNEEFNSDTLLKLYASLLPRQTKTRFKLPTDLKTD- 951
            .           :||.|.|.         |.|:..||.::|:.| ||..|.|...::......|
Mouse   920 I-----------ILKTSGQKIKSHIQQLRVEEDVASDLVMKVDA-LLSAQPKGEARIEYQFFEDK 972

  Fly   952 HSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVKNF 1016
            ||.:||.|| |...::||.||:||.:|.||:|.|:|::|.|::|..|.:::....:.||||:|:|
Mouse   973 HSAIKLKPK-EGETYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSDMPLKSF 1036

  Fly  1017 YRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLDNIKLTDIGG 1081
            ||||:|||:.|.|:...:.||:|||..:|.:||.|..|..||:|:||:||..||||||.|.::..
Mouse  1037 YRYVLEPEISFTADSSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDS 1101

  Fly  1082 PVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMANLGYFQLKANPGAWSLR 1146
            .|.:|::||||||||||:|..:|.||||||..|||.:.||:|||||||||||||||||||||.||
Mouse  1102 IVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTIVMANLGYFQLKANPGAWILR 1166

  Fly  1147 LREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAELLSD-DNEQA 1210
            ||:|:|.|||.|...:||::...|  ::|.|::.:.:|.::|::|.||..|...:|||| .||.
Mouse  1167 LRKGRSDDIYRIYSHDGTDSPPDA--NDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNEN- 1228

  Fly  1211 AQSGMWNSIASSFGGGSANQAATDEDTETINIFSVASGHLYERLLRIMMVSLLKHTKSPVKFWFL 1275
             :||.|:|....|.|..|.:...|:| :.||||||||||||||.|||||:|:||:||:|||||||
Mouse  1229 -ESGFWDSFKWGFSGQKAEEVKQDKD-DIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFL 1291

  Fly  1276 KNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLNVRKIIF 1340
            ||||||.|.:|:|:||.:||||||||||||||||||||||||.|||||||||||||||.|.|.:|
Mouse  1292 KNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLF 1356

  Fly  1341 VDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHISALYVVD 1405
            ||||.|||||:|||.|.:|.||||.||||||||:||:|:||||.|||.|||.||:||||||||||
Mouse  1357 VDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVD 1421

  Fly  1406 LKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCSDSNFKT 1470
            ||:|||||||||||||||.|||||||||||||||||||||||.|||||.:||||:|||.|::.|.
Mouse  1422 LKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKR 1486

  Fly  1471 AKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIEDHENSHSRDSAVDDSVDDSVEVT 1535
            ||.|||||||.|||.||.||.||||||:|||.|:|.|.:..::.:                 |:.
Mouse  1487 AKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEK-----------------ELG 1534

  Fly  1536 TV----TPSHEPKHGEL 1548
            |:    |.....||.||
Mouse  1535 TLHTEETQEGSQKHEEL 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	Thioredoxin_12	40..227	CDD:465748	52/186 (28%)
		Thioredoxin_13	300..414	CDD:465749	50/113 (44%)
		Thioredoxin_14	440..692	CDD:465750	94/253 (37%)
		Thioredoxin_15	717..934	CDD:465751	62/242 (26%)
		UDP-g_GGTase	1095..1204	CDD:461910	60/108 (56%)
		Glyco_transf_24	1240..1507	CDD:436473	216/266 (81%)
Uggt1	NP_942602.2	Thioredoxin_12	57..237	CDD:465748	52/186 (28%)
		Thioredoxin_13	311..438	CDD:465749	52/126 (41%)
		Thioredoxin_14	451..699	CDD:465750	94/253 (37%)
		Thioredoxin_15	723..955	CDD:465751	63/243 (26%)
		UDP-g_GGTase	1116..1222	CDD:461910	59/107 (55%)
		Glucosyltransferase. /evidence=ECO:0000250	1244..1551		225/324 (69%)
		Glyco_transf_24	1256..1523	CDD:436473	216/266 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1531..1551		5/36 (14%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	1548..1551		1/2 (50%)