DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uggt and gpt1

DIOPT Version :9

Sequence 1:	NP_524151.2	Gene:	Uggt / 40055	FlyBaseID:	FBgn0014075	Length:	1548	Species:	Drosophila melanogaster
Sequence 2:	NP_595281.1	Gene:	gpt1 / 2541413	PomBaseID:	SPBPJ4664.06	Length:	1448	Species:	Schizosaccharomyces pombe

Alignment Length:	1607	Identity:	490/1607 - (30%)
Similarity:	768/1607 - (47%)	Gaps:	280/1607 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YPITTLINAKWTQTPLYLE-------------IAEYLADE-QAGLFWDYVSGVTKLDTVLNEYDT 78
            :.|.|||...:...||.::             |||.|..| :.|..| |::.::  |.:..|..|
pombe     7 FAIATLITICYAAKPLDVKIAATFNAPSFSALIAESLYQEKKEGFIW-YLNHLS--DLLDAENTT 68

  Fly    79 ESQQY-NAALELVKSHV-SSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQSFTFAQVGS 141
            |.:.| |....|.:.:| |..:|..|:..:.:.|..|::|....:.:    |.||...|:.|:..
pombe    69 EKELYINVVNSLKREYVLSDEELSSLQFSLGLFSGAPKLQAFSSIVQ----SRSCDCDTWLQLDE 129

  Fly   142 ELACSFNELQKKLEVPL-----AKDSLDASVVTYSFDHIFPGSENNTRTVVLYGDLGSSQFR--- 198
            |....|::|.|  :.||     :|:.||..||            ..:.|.:.|..:.:|..|
pombe   130 ESQVCFSDLPK--DSPLFSKLYSKNPLDYEVV------------KTSATGIPYAVVVTSFERDLI 180

  Fly   199 TYHKLLEKEANAGRIRYILRHQLAKKDKRPVRL--SGYGVELHLKSTEYKSQDDAPKPE------ 255
            .:|:|..|.|..|:..|::|:......|...:|  .|:|..:.||.|:|...||...|.
pombe   181 PFHELYYKLALEGKCNYVIRYSPPSSSKLNSKLYVKGFGTHVSLKRTDYLVVDDREFPREKGDNP 245

  Fly   256 AGSTSDEDLANESDVQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAA 320
            |..||..:..:...:.|.....|:...|                 |:||        .|.|.|..
pombe   246 ASFTSSRNKRSNERLFGMTSDSLQTVTP-----------------DKIA--------ILDLLATQ 285

  Fly   321 AIAEIQGDETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHN-TEAFGRSLNVAPPDG--ALF 382
            :||  ...:.|...:....:||:.|..|       .::.:|.:: .|...:..:...|:|  .::
pombe   286 SIA--SSTDMLTAFRELTQDFPIYAHYL-------SIQPDVSNDLIEELNQFQSQYVPEGINTIW 341

  Fly   383 INGLFFDADTMDLYSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKKEFAI------- 440
            :|||..|.:..|.:|::..::.|..:.:...:..::.|....::..:..|:...:|..
pombe   342 LNGLSLDLEETDAFSILSLIKKEKDMFDRFEALGIKSSKVLDIVTNEAFANEDSDFKFVKFHCQD 406

  Fly   441 DIRD-TAVQWVNDIENDVQYRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVIK 504
            ||.| .|:.|||:||::.:|..||.|:..||:|.:||.|..:.|.:..::..:....|::..::.
pombe   407 DIEDWKAIHWVNEIESNPKYDNWPKSIQILLKPIYPGQLHMLGKQLHTVIYPIFPSSPSSLPLLS 471

  Fly   505 LSESFVIHQAPIRLGLVFDARDANEDNLADYVAITC-AYNYVSQKKDARAALSFL---------T 559
            ....|....:|::.|:|..|.|.:|     :....| ::.|:|::....:||.||         .
pombe   472 ELIQFSRRPSPVQTGMVCAANDDDE-----FAQTVCKSFFYISKESGTDSALKFLYKCLNSDSSA 531

  Fly   560 DIYAAVGETKVVTK--KDIVKQLTKEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKG 622
            |:|:.:.|...:::  .|.:..|.|:.:|             |.:|:....:..::.|||. |..
pombe   532 DLYSLLEEHLPLSEHDDDTLANLKKDLSS-------------SFFDHYMSKSNSWVNRLGI-DSS 582

  Fly   623 QPQALLNGVPMPSNVVTADSDFEEAIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLM------NQ 681
            ..:.::||     .:::.|.:::.:::...:.....:|.||.:|:::::|..:|:::      ..
pombe   583 ASEVIVNG-----RIISHDENYDRSMYGIFLEDIPEVQIAVAEGKISEDDNLLDFILRDASLTRN 642

  Fly   682 PHVMPRLNQRILSQEDVKYLDINGVAYKNLGNVGVLNRLSNRDMTATLMDNLKYFGGKKSTELIG 746
            |.|.|.      ::..:|.:||..|    |.|||.||   :.|:......|.||
pombe   643 PLVYPS------AKSSIKSIDIKRV----LENVGSLN---HEDILLIGSSNAKY----------- 683

  Fly   747 RASLQFLTIWVFADLETDQGRDLLTHALDYVQSGESVRVAFI---------PNTESSSASSRRNL 802
                   :.|:.||....:|.::|:...|.:...:...:..|         |......:|.:|:.
pombe   684 -------SFWLVADFNEKEGLEILSLLADLLSENKDANLMLIQEGKNHVVPPLFAKLLSSPKRSS 741

  Fly   803 NRLVWAAMQSLPPTQAT----EQVLKWLKKPKEKIEIPTQLEDILGSTELHLKMLRVYSQRVLGL 863
            ..|......||.|:...    ::.||:|||.|..::            ||.|          .|.
pombe   742 KHLQEILNSSLDPSSGVVNDMDKALKFLKKSKAVVK------------ELGL----------TGE 784

  Fly   864 NKSQRLVIGNGRLYGPLSSDESFDSADFALLARFSSLQYSDKVRQVLKESAQDVNEEFNSDTLLK 928
            .||..|:  |||:....|.| |.::||..:|.:.....|..|:..:...|.:..|..
pombe   785 CKSALLL--NGRMICSFSVD-SLNTADLKMLMQMEYDNYLSKLSNIAGSSRRLKNSR-------- 838

  Fly   929 LYASLLPRQTKTRFKLPTDLKTDHSVVKLPPKQENL------------------------PHFDV 969
             ..|.|....||....|....:       |.|:|.|                        .::..
pombe   839 -AISFLSSYLKTLESTPMSTSS-------PTKEEKLFPRDFIYNKLGVGNATFETDDFSKAYYQF 895

  Fly   970 AAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVKNFYRYVVEPEVQFEANGGRS 1034
            .|||||.|:.:||.:.||..:.::....:.::..|....|::|:..||||.:..|.:|:|.|...
pombe   896 VAVLDPLSKDSQKWSAILEAVSKLNGVGVRIHFNPKQTLSELPLTRFYRYSISAEPEFDALGHLE 960

  Fly  1035 DGPLAKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLDNIKL--TDIGGPVHSE---FDLEYLLL 1094
            :. ..:|..|||:.|||..::..:.|.|.......||.||||  |.....:.|.   ::|:.:|:
pombe   961 ES-YVEFDNLPADTLLTMDIEARDAWTVMQKDVDIDLFNIKLEHTSEAEALDSHTAIYELKNILV 1024

  Fly  1095 EGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMANLGYFQLKANPGAWSLRLREGKSADIYAIS 1159
            :|:..:....:||||:||.||..:...:.||||::||||||||||||.|:|...:|:|:..|.|.
pombe  1025 QGYSQEEFRKSPPRGMQLKLGNLTNSHVTDTIVLSNLGYFQLKANPGVWTLEPMDGRSSQFYEIL 1089

  Fly  1160 HIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAELLSDDNEQAAQSGMWNSI--ASS 1222
            .:...|::     .:.||::.|.....:...:.:|||.:.|:::.:|   .:....::.|  :.|
pombe  1090 SLNKKNSY-----KDPQVIVDSFEGVTLNPVMRRKPGFESADIMDED---LSSHKFFDKIKKSLS 1146

  Fly  1223 FGGGSANQAATDEDTETINIFSVASGHLYERLLRIMMVSLLKHTKSPVKFWFLKNYLSPQFTDFL 1287
            |......:|       :||||||||||||||.|.||..|:::||...|||||::|:|||.|...:
pombe  1147 FFNFKRKEA-------SINIFSVASGHLYERFLYIMTKSVIEHTDKKVKFWFIENFLSPSFKSSI 1204

  Fly  1288 PHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLNVRKIIFVDADAIVRTDIK 1352
            |.:|.:|||:||.:.|.||.||.:|.||||.|||||||||||||||.:.|:|:||||.|||.|::
pombe  1205 PAIAKKYNFEYEYITYNWPHWLRKQEEKQREIWGYKILFLDVLFPLELHKVIYVDADQIVRADLQ 1269

  Fly  1353 ELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHISALYVVDLKRFRKIAAGDR 1417
            ||.||||.||||.|||.||||:|||||||||:|||:..|.|.:|||||||||||.||||:.|||.
pombe  1270 ELMDMDLHGAPYGYTPMCDSREEMEGFRFWKKGYWKKFLRGLKYHISALYVVDLDRFRKMGAGDL 1334

  Fly  1418 LRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCSDSNFKTAKVIDLCNNPQT 1482
            ||.|||.||.||||||||||||||::.|.:.|.|||.|||||:|||||.:.||||.||||.||.|
pombe  1335 LRRQYQLLSADPNSLSNLDQDLPNHLQHLIPIYSLPQDWLWCETWCSDESLKTAKTIDLCQNPLT 1399

  Fly  1483 KEAKLTAAQRIVPEWKDYDAELKTLM--------SRIEDHENSHSRD 1521
            ||.||..|:|.|.||..||.|:.:::        ...|:.:|:.|.|
pombe  1400 KEKKLDRARRQVSEWTSYDNEIASVLQTASSQSDKEFEEKDNNSSPD 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	UDP-g_GGTase	29..1196	CDD:283964	298/1269 (23%)
		RfaJ	1238..>1456	CDD:224359	147/217 (68%)
		GT8_HUGT1_C_like	1240..1487	CDD:133054	170/246 (69%)
gpt1	NP_595281.1	UDP-g_GGTase	20..1121	CDD:283964	294/1257 (23%)
gpt1	NP_595281.1	GT8_HUGT1_C_like	1157..1404	CDD:133054	170/246 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I114
eggNOG	1	0.900	-	-		E1_KOG1879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10586
Inparanoid	1	1.050	653	1.000	Inparanoid score	I124
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002023
OrthoInspector	1	1.000	-	-		oto100720
orthoMCL	1	0.900	-	-		OOG6_101176
Panther	1	1.100	-	-	LDO	PTHR11226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2174
SonicParanoid	1	1.000	-	-		X1498
TreeFam	1	0.960	-	-
	13	12.850