DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uggt and uggt-1

DIOPT Version :9

Sequence 1:	NP_524151.2	Gene:	Uggt / 40055	FlyBaseID:	FBgn0014075	Length:	1548	Species:	Drosophila melanogaster
Sequence 2:	NP_509268.1	Gene:	uggt-1 / 181007	WormBaseID:	WBGene00018604	Length:	1493	Species:	Caenorhabditis elegans

Alignment Length:	1565	Identity:	633/1565 - (40%)
Similarity:	924/1565 - (59%)	Gaps:	114/1565 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VALCVSVVLIALYTPTSGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKL 69
            :..|...||.||         :...:.|.:.|.|..|.|..|.:|::|:|...||..::..|.|.
Worm     8 IFFCHIAVLAAL---------EKKGVHTSLKANWDSTSLLAEASEFIAEENEKLFVKFIDIVNKD 63

  Fly    70 DTVLN-EYDTESQQYNAALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQS 133
            ...|| |..|:.|:|...::.....:|:..:.||:..:::...:||:|:..|:|.|.  ...|.
Worm    64 VGTLNWEKLTDEQKYEYTIKTAGKVLSTSSVDLLKFALALRQYSPRVQSFQQIAVEY--GEKCD- 125

  Fly   134 FTFAQVGSELACSFNELQKKLEVPLAKDSLDASVVTYSFDHIFPGSENNTRTVVLYGDLGSSQFR 198
             .|..||.:::|.:.:|:|     :.||:...|.|..| |||| |.::..:..:|||:||::.|.
Worm   126 -VFVVVGEQVSCEYTKLEK-----MIKDAKTNSQVLES-DHIF-GEKDLKQAAILYGELGTTSFA 182

  Fly   199 TYHKLLEKEANAGRIRYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGSTSDED 263
               |..||.:...:.:.|.||...|.|..||.||||||||.:|:||||:.|::.:.:   ..:||
Worm   183 ---KAWEKLSKLQKTKLIFRHFSKKTDSHPVSLSGYGVELAIKNTEYKAVDESSEKK---NVEED 241

  Fly   264 LANESDVQGFDFKVLKQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAAAIAEIQGD 328
               |:|:.||:.|:||:.||....|::..|..|.: :||:..||.||.|||..|||..|......
Worm   242 ---EADLFGFNIKLLKELHPDSVDAIESFRVNLKE-SDELTPLKRWELQDLSYQAAQKIVNAGPA 302

  Fly   329 ETLQILQYTAHNFPMLARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTM 393
            :.:..|:..:.|||..||.|....|:|.||.||..|.:...:: ::...:.:|:|||:..|.:::
Worm   303 DAIGTLEEYSQNFPTHARALAKTSVSDLLRKEVLQNRKMLEKA-SIEVGETSLYINGINQDINSL 366

  Fly   394 DLYSLIETLRSEMRVLESLHSNNVRGSLASSLLALDLTASSKKEFAIDIRDTAVQWVNDIENDVQ 458
            ||:.|.:.|:.|.::.:..||..:.....|.|:.:|.:...|..:|:|.|:....::|:::.|.:
Worm   367 DLFKLADLLKQENKLADGFHSMGINREYLSILVGMDTSDDEKTTYAVDHREGYPFFINNLDTDKK 431

  Fly   459 YRRWPSSVMDLLRPTFPGMLRNIRKNVFNLVLVVDALQPTARSVIKLSESFVIHQAPIRLGLVF- 522
            |::|.:||..:|:|.:|||:|.|.:|:|:||.|||......|..:::.::|..|...:|:|.:|
Worm   432 YKQWGNSVKLMLQPYYPGMIRPIARNLFSLVFVVDPSTSEGRKFLRIGQTFNSHDIAMRIGYIFA 496

  Fly   523 ---DARDANEDNLADYVAITCAYNYV---SQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQLT 581
               |.:.:.|.:|.  ||:...:|:|   |...||...|:...|.|    .:|..|.:||.:...
Worm   497 VNQDTKASGETDLG--VALLNLFNFVSIDSSNADALKVLNNFLDDY----RSKDPTIEDIKEFFE 555

  Fly   582 KEFTSLSFAKAEEFLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEE 646
            .:|:..||:   :....:|.||.||:...||:|:.|.  ...|:.||||..:....|..| :.||
Worm   556 AKFSDASFS---DVFGVNSDYDKGRKHGFEFVQKTGL--NSAPKVLLNGFILDDEGVRGD-NIEE 614

  Fly   647 AIFTEIMTHTSNLQKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQEDVK-YLDING-VAYK 709
            .|..|:|..:..:|:|:.:|:|||.....::::.|..||||:|:||||....| |::|.| :..|
Worm   615 TIMMEVMKISPKIQRAIMEGKLTDRMNVGNWVLEQKDVMPRINKRILSAPSKKTYVEILGSMDCK 679

  Fly   710 NLGNVGVLNRLSNRDMTATLMDNLKYFGGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHAL 774
            :|.:|   ..||:.|....|:...||. .|.|.:     |:..:|:||.||.|...||..:.::|
Worm   680 SLKDV---ENLSDSDKAGCLLQTTKYL-QKASAD-----SILPVTLWVVADAEAASGRRFIYNSL 735

  Fly   775 DYVQSGESVRVAFIPNTES-SSASSRRNLNRLVWAAMQSLPPTQATEQVLKWLKK--PKEKIEIP 836
            ..:::..:.||..|.|.|| ..|....:::..:.||:..||..||...:||...:  ..:.|...
Worm   736 QILKNSANSRVGIIFNPESVEKACESNSISSYIRAALDFLPMDQAKRLILKLSNEEYAADFISGK 800

  Fly   837 TQLEDI-LGSTE----------LHLKMLRVYSQ---RVLGLNKSQRLVIGNGRLYGPLSSDESFD 887
            ...:|: :|..:          |..:..|:.||   :||.::...|:|:||....|||.|.|.|:
Worm   801 ITFDDLSVGGMDTAKFLADKKKLDCERTRLESQIVKKVLDISSGGRVVVGNALQVGPLESSEHFE 865

  Fly   888 SADFALLARFSSLQYSDKVRQVLKESAQDVNEEFNSDTLLKL------YASLLPRQTKTRFKLPT 946
            :|||.||......:.::.:...||:...||:....|:|:..:      :||   .|.:|...:..
Worm   866 AADFKLLESMLLSRGAEVISSHLKKWEFDVSNGVGSNTVFSIAGHVGKHAS---SQKRTWVSIQG 927

  Fly   947 DLKTDHSVVKLPPKQENLPHFDVAAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDM 1011
            |   :||||.||..:.:.|..||.||:||.:..||||..||.|:::|.||::.:.:.|..:||::
Worm   928 D---EHSVVTLPADEMDRPAVDVLAVVDPLTMEAQKLGSILHLIKKVTNCEIKIVMNPKDKHSEL 989

  Fly  1012 PVKNFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENWLVEAVRAVYDLDNIKL 1076
            |:|.||||....|:.|:.||..:.. :.:|..||:..|||..||.|::|:||||.|.|||||||:
Worm   990 PLKRFYRYAAASELSFDHNGNLNTN-VVRFDNLPSKQLLTLSLQAPDSWIVEAVSAKYDLDNIKM 1053

  Fly  1077 TDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMANLGYFQLKANPG 1141
            ....|.|.:||.|::|||:|.|||..||.||||||..|||...|...||||||||||||||||||
Worm  1054 EQANGDVTAEFALQHLLLDGQCFDEVSGQPPRGLQFTLGTDKNPKQFDTIVMANLGYFQLKANPG 1118

  Fly  1142 AWSLRLREGKSADIYAI-SHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKPGMQQAELLSD 1205
            ||.|.:|:|||::||.| ||:..    ...|...:||:|.|.....|::||.|:.||::..||||
Worm  1119 AWKLEIRDGKSSEIYKIGSHVGA----EKIGEDVLQVVIDSFTGKSVRVRVEKREGMEERNLLSD 1179

  Fly  1206 DNEQAAQSGMWNSIASSFGGGSANQAATDEDT-ETINIFSVASGHLYERLLRIMMVSLLKHTKSP 1269
            |.|     |:|:|:        :|..::.|.| |.||:||:||||||||.:|||:||::|:||.|
Worm  1180 DEE-----GVWSSL--------SNLVSSKEKTQEVINVFSLASGHLYERFMRIMIVSVMKNTKHP 1231

  Fly  1270 VKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLN 1334
            ||||.|||||||||.:.||.:|..|.|:|||::||||||||||.||||.:||:|||||||||||:
Worm  1232 VKFWLLKNYLSPQFKETLPTLAKHYGFEYELIEYKWPRWLHQQKEKQRIMWGFKILFLDVLFPLD 1296

  Fly  1335 VRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSHLMGRRYHIS 1399
            |:|:||||||.:||.|:.||...|||.|||.|.|||:|||||:||||||||||.:||.|||||||
Worm  1297 VQKVIFVDADQVVRADLMELMKFDLGNAPYGYVPFCESRKEMDGFRFWKQGYWANHLAGRRYHIS 1361

  Fly  1400 ALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDDWLWCQTWCS 1464
            ||||:||::||:||||||||||||.||.|||||:||||||||||||||.|||||.:||||:|||.
Worm  1362 ALYVIDLQKFRQIAAGDRLRGQYQGLSGDPNSLANLDQDLPNNMIHQVKIKSLPQEWLWCETWCD 1426

  Fly  1465 DSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIEDHENSHSRDSAVDDSVD 1529
            |.:.|.||.|||||||.|||.||.:|.||:.|||.||.|::.::|   .|.:.:..|:.:.::.|
Worm  1427 DGSKKNAKTIDLCNNPLTKEPKLDSAARIIGEWKTYDDEIREVIS---GHSSDNPSDNVISENDD 1488

  Fly  1530 DSVEV 1534
            ...|:
Worm  1489 SHTEL 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uggt	NP_524151.2	UDP-g_GGTase	29..1196	CDD:283964	414/1200 (35%)
		RfaJ	1238..>1456	CDD:224359	163/217 (75%)
		GT8_HUGT1_C_like	1240..1487	CDD:133054	183/246 (74%)
uggt-1	NP_509268.1	UDP-g_GGTase	22..1170	CDD:283964	414/1201 (34%)
uggt-1	NP_509268.1	GT8_HUGT1_C_like	1202..1449	CDD:133054	183/246 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167584
Domainoid	1	1.000	436	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_KOG1879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10586
Inparanoid	1	1.050	1064	1.000	Inparanoid score	I128
Isobase	1	0.950	-	0	Normalized mean entropy	S3130
OMA	1	1.010	-	-		QHG55769
OrthoDB	1	1.010	-	-		D231263at2759
OrthoFinder	1	1.000	-	-		FOG0002023
OrthoInspector	1	1.000	-	-		oto17466
orthoMCL	1	0.900	-	-		OOG6_101176
Panther	1	1.100	-	-	LDO	PTHR11226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2174
SonicParanoid	1	1.000	-	-		X1498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750