DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad9 and rad9b

DIOPT Version :9

Sequence 1:	NP_001097639.2	Gene:	Rad9 / 40054	FlyBaseID:	FBgn0025807	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001307283.1	Gene:	rad9b / 563903	ZFINID:	ZDB-GENE-040910-3	Length:	402	Species:	Danio rerio

Alignment Length:	410	Identity:	104/410 - (25%)
Similarity:	176/410 - (42%)	Gaps:	54/410 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYTLEGSNARVIAKAVQSLSKVGKEMFIEIDQQSLQMRAINATQSAVGSISFKRSMFEVYDMPP 65
            ||..:||:..:|..:|:.:||::|.|::::..:..|.:|.:|::||......|....|:.|...|
Zfish     1 MKCVIEGNGIKVFGRAIHALSRIGDEIWLDPLEDGLAVRTVNSSQSGYACFCFAPLFFQQYIPDP 65

  Fly    66 HSD----FYCKISMKGCLAVFR----NMNEVEYCELNLLDNQTNLQVNLRCKLETTKEATISIID 122
            .:.    ..||:::|..|.:||    ....|:.||:::......:.....|:...||...:...:
Zfish    66 ATKDSQAVKCKLNLKCVLPMFRCVTCRERSVDRCEISIKIPDGRVTFRFHCRHGITKTHNLGYQE 130

  Fly   123 DQNINTNINTDQMPNIIRGDHKLLTDISNNFNSSEEELTLEANSGSVVAKNYIEGARVND--KFM 185
            .:.:.........||::....|||..|..:|..|:||:||..:|..||.|.:.  ...||  |.|
Zfish   131 CEALQAVFPAHLSPNVLMAQSKLLGGIVVHFPVSQEEVTLSVSSLKVVLKTFC--VEENDCIKGM 193

  Fly   186 RTQLKLKPSEFEQYQVTKETVITFCIKEFRAFLLFAECLNASLTLEFDEAGMPFLLKIKKHGEIE 250
            .|.|.|.|.|.:.:||.:::.:|||:||.|..|.||||....::.:|..||.|....:|.. .:|
Zfish   194 NTALMLHPDELDYFQVGEDSDVTFCLKELRGLLSFAECYGLPVSCQFGAAGQPISFTVKDI-TLE 257

  Fly   251 CLLIMSTL-SPDDISFSEDYCQKDLTVQDEDVRAAAAKRKSSVSKPNVT------NKRKGSSSEP 308
            ..:::||| :||..|.|:...:.|..|:   ...|:....|:..:|...      .:|..||...
Zfish   258 AHVVLSTLTNPDSESSSQPAPRDDCPVK---TPKASTAENSTYEEPMEAEVCVSDGERVASSQGS 319

  Fly   309 AAVQPKRRVEE-TQL---ESSLDNPLFQ------------------------FRDSEAPSVQHPR 345
            ....|.|.:.: .||   |..|..|.|.                        :...:..:...|.
Zfish   320 EMFSPARHMRKMMQLHAPEEILQRPCFAPESVLTTPVTPATFKIRSLLFGAVYNSGDGKAADFPS 384

  Fly   346 ILAEVDTVVLIEDEAEQEAL 365
            ::...||.   :|...||.:
Zfish   385 LVYASDTE---DDGGTQETI 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad9	NP_001097639.2	PCNA	7..262	CDD:238322	76/265 (29%)
Rad9	NP_001097639.2	Rad9	13..258	CDD:282052	71/254 (28%)
rad9b	NP_001307283.1	PCNA	10..229	CDD:238322	61/220 (28%)
rad9b	NP_001307283.1	Rad9	13..265	CDD:282052	71/254 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579978
Domainoid	1	1.000	141	1.000	Domainoid score	I4666
eggNOG	1	0.900	-	-		E1_KOG2810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4293
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176140at2759
OrthoFinder	1	1.000	-	-		FOG0002689
OrthoInspector	1	1.000	-	-		otm24968
orthoMCL	1	0.900	-	-		OOG6_103735
Panther	1	1.100	-	-	LDO	PTHR15237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1066
SonicParanoid	1	1.000	-	-		X3445
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790