DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rad9 and rad9a

DIOPT Version :9

Sequence 1:	NP_001097639.2	Gene:	Rad9 / 40054	FlyBaseID:	FBgn0025807	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_956501.2	Gene:	rad9a / 393176	ZFINID:	ZDB-GENE-040426-935	Length:	381	Species:	Danio rerio

Alignment Length:	432	Identity:	115/432 - (26%)
Similarity:	189/432 - (43%)	Gaps:	85/432 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GSNARVIAKAVQSLSKVGKEMFIEIDQQSLQMRAINATQSAVGSISFKRSMFEVYDMPPHSDFYC 71
            |:|.:|:|||:.|||::|:|:::|.....|.:|::|:::||..|.......|:.|..|....|.|
Zfish     7 GANVKVLAKAIHSLSRIGEELYLEPVDDGLALRSVNSSRSAFASFQLSPLFFQRYQAPTDQSFRC 71

  Fly    72 KISMKGCLAVFRNMN----EVEYCELNLLDNQTNLQVNLRCKLETTKEATISIIDDQNINTNINT 132
            |:.:|...|||::::    .||.|.:.|...::.|.:.|.||....|...:|..|.:::....:.
Zfish    72 KMPIKSVQAVFKSLSSLERSVEKCRIQLNSEKSRLTITLHCKHGLLKTHNLSFQDCESLQAVFDK 136

  Fly   133 DQMPNIIRGDHKLLTDISNNFNSSEEELTLEANSGSVVAKNYIEGARVNDKFMRTQLKLKPSEFE 197
            :...|:::...:|:.|...:|..|.||:.|..:|..|..:|::|....:.:.|.|:|.|...||:
Zfish   137 ESCTNVLQAQPRLMVDTVLHFPPSLEEVNLSVSSDRVWLRNHVEDDADSSRAMMTELCLSSEEFD 201

  Fly   198 QYQVTKETVITFCIKEFRAFLLFAECLNASLTLEFDEAGMPFLLKIKKHGEIECLLIMSTLSPDD 262
            .:.::.:|.||||:||.|..|.|||.....:::.|||.|.|.:|.: ....:|...:::|||.|
Zfish   202 HFAISSQTSITFCLKELRGLLGFAESSCLPISMYFDEPGSPVILNV-TDSVLEANFVLATLSED- 264

  Fly   263 ISFSEDYCQKDLTVQDEDVRAAAAKRKSSVSKPNVTNKRKGSSSEPAAVQPKRRVEETQLESSLD 327
                                        |.||.:|.:..|    .|.|.||    .:..:...:|
Zfish   265 ----------------------------SHSKNHVNSNTK----RPDAEQP----PDDFMSDDMD 293

  Fly   328 NPLFQFRDSEAPSVQHPRILAEVDTVVL---------IEDEAEQEALMLAAADAALEASMAPAPE 383
            :.|.....||.|...|      |.|..|         ..|:.|:|||               |..
Zfish   294 SFLIAMETSELPGPSH------VPTSPLQPINNRKHSASDDEEEEAL---------------AER 337

  Fly   384 PPNSTEVCFI------------NTDDSQQPKPAKSSSDEDET 413
            |||. :.|.:            |.....|...|..|.||::|
Zfish   338 PPNK-KFCSLFFGSVLPTPSLTNQTIQSQEVLASDSEDENQT 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad9	NP_001097639.2	PCNA	7..262	CDD:238322	79/258 (31%)
Rad9	NP_001097639.2	Rad9	13..258	CDD:282052	73/248 (29%)
rad9a	NP_956501.2	PCNA	5..263	CDD:238322	78/256 (30%)
rad9a	NP_956501.2	Rad9	13..261	CDD:282052	73/248 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579979
Domainoid	1	1.000	141	1.000	Domainoid score	I4666
eggNOG	1	0.900	-	-		E1_KOG2810
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4293
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176140at2759
OrthoFinder	1	1.000	-	-		FOG0002689
OrthoInspector	1	1.000	-	-		otm24968
orthoMCL	1	0.900	-	-		OOG6_103735
Panther	1	1.100	-	-	O	PTHR15237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1066
SonicParanoid	1	1.000	-	-		X3445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790