DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rad9 and Rad9a

DIOPT Version :9

Sequence 1:	NP_001097639.2	Gene:	Rad9 / 40054	FlyBaseID:	FBgn0025807	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_035367.1	Gene:	Rad9a / 19367	MGIID:	1328356	Length:	389	Species:	Mus musculus

Alignment Length:	482	Identity:	122/482 - (25%)
Similarity:	192/482 - (39%)	Gaps:	121/482 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKYTLEGSNARVIAKAVQSLSKVGKEMFIEIDQQSLQMRAINATQSAVGSISFKRSMFEVYD-MP 64
            ||..:.|.|.:|:.|||.|||::|.|:::|..:..|.:|.:|:::||.....|....|:.|. ..
Mouse     1 MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQYQAAS 65

  Fly    65 PHSDFY-CKISMKGCLAVFRNM----NEVEYCELNLLDNQTNLQVNLRCKLETTKEATISIIDDQ 124
            |..|.. |||.||..|:|||::    ..||.|.::|..:.::|.|.|.||....|...:|..|.:
Mouse    66 PGQDLLRCKILMKAFLSVFRSLAIVEKSVEKCCISLSGSHSHLVVQLHCKYGVKKTHNLSFQDCE 130

  Fly   125 NINTNINTDQMPNIIRGDHKLLTDISNNFNSSEEELTLEANSG-SVVAKNY-IEGARVNDKFMRT 187
            ::....:....|:::|...::|.:...:|..:..|:||....| .|:.::| .|.|....|.|.|
Mouse   131 SLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVT 195

  Fly   188 QLKLKPSEFEQYQVTKETVITFCIKEFRAFLLFAECLNASLTLEFDEAGMPFLLKIKKHGEIECL 252
            :..:...:|:|....:...:|||:||||..|.|||..|..||:.||..|.|.:..| :...::..
Mouse   196 ETSIGDEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPLTIHFDVPGRPVIFTI-EDSLLDAH 259

  Fly   253 LIMSTLSPDDISFSEDYC---------QK---------DLTVQDEDVRAAAAKRKSSVSKPNVTN 299
            .:::||...| |.|:..|         ||         |.|..|.|....|.:         .|.
Mouse   260 FVLATLLEQD-SCSQGPCSPKPHQPVPQKQAHSTPHLDDFTSDDIDCYMIAME---------TTG 314

  Fly   300 KRKGSSSEPAAVQPKRRVEETQLESSLDNPLFQFRDSEAPSVQHPRILAEVDTVVLIEDEAEQEA 364
            ..:||.::|:...|                              |..||..|.....|:||
Mouse   315 GNEGSGAQPSTSLP------------------------------PVSLASHDLAPTSEEEA---- 345

  Fly   365 LMLAAADAALEASMAPAPEPPNSTEVCFINTDDSQQPKPAKSSSDEDETIPQSPERPNKVRTI-F 428
                                                         |..|:|.:|. |.|.|:: |
Mouse   346 ---------------------------------------------EPSTVPGTPP-PKKFRSLFF 364

  Fly   429 SRCFQRTYVPREPSPNTQVYAPNSDTE 455
            .......:.|:.|:|   |.|.:||.|
Mouse   365 GSILAPVHSPQGPNP---VLAEDSDGE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad9	NP_001097639.2	PCNA	7..262	CDD:238322	81/262 (31%)
Rad9	NP_001097639.2	Rad9	13..258	CDD:282052	76/252 (30%)
Rad9a	NP_035367.1	PCNA	9..267	CDD:238322	80/258 (31%)
		Rad9	13..265	CDD:282052	76/252 (30%)
		Possesses 3'-5' exonuclease activity. /evidence=ECO:0000250	51..91		14/39 (36%)
		Sufficient for interaction with ABL1. /evidence=ECO:0000250	266..389		39/216 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..296		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..389		28/160 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836455
Domainoid	1	1.000	119	1.000	Domainoid score	I5782
eggNOG	1	0.900	-	-		E1_KOG2810
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32118
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4607
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176140at2759
OrthoFinder	1	1.000	-	-		FOG0002689
OrthoInspector	1	1.000	-	-		otm43963
orthoMCL	1	0.900	-	-		OOG6_103735
Panther	1	1.100	-	-	O	PTHR15237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1066
SonicParanoid	1	1.000	-	-		X3445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790