DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dysb and Dtnbp1

DIOPT Version :9

Sequence 1:	NP_001262023.1	Gene:	Dysb / 40052	FlyBaseID:	FBgn0036819	Length:	288	Species:	Drosophila melanogaster
Sequence 2:	NP_001032753.1	Gene:	Dtnbp1 / 641528	RGDID:	1590759	Length:	352	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	77/296 - (26%)
Similarity:	140/296 - (47%)	Gaps:	48/296 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGNLKKKLSSAIQEGLVISENLQQQYRQRVSSGNSGSSQASGITTPISPLGLNESLSSSRSSSL 65
            |...|:::|.|           :||.:             .||:.|      |::....::..|.
  Rat     1 MLETLRERLLS-----------VQQDF-------------TSGLKT------LSDKSKEAKVKSR 35

  Fly    66 SLSAPFQLTDGVPSHLNVAAGCSLLAKYEDDWQQIHGANEKNAEKAAQIANQISGIQDQASHQHR 130
            ..:||:     :|.:   :||..||::|||.|..:|...::.|:....:.:::..:......:..
  Rat    36 PRTAPY-----LPKY---SAGLDLLSRYEDTWAALHRRAKECADAGELVDSEVVMLSAHWEKKRT 92

  Fly   131 IMSELNSSLAGIPTLIAQLQNSSQVLNSLEEMGKQLEIELEKLEDLREECELQEFILEQQFQLSR 195
            .::||...|..:|.|:..:::....|..||...:::|..|..||||..:|||:.........|..
  Rat    93 SLAELQEQLQQLPALLQDVESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAHARHLED 157

  Fly   196 HKQKKLNELEQYRQQIAQKHQSKIKDQEQT-LLKLQRERQAVFDDAFREDMEEYKQRG--QLTKI 257
            :|:.|..|||.::.::..:|..||.:.|.| .||| :|||..|::||::|||:|...|  |:.:.
  Rat   158 YKKSKRKELEAFKAELDTEHAQKILEMEHTQQLKL-KERQKFFEEAFQQDMEQYLSTGHLQIAER 221

  Fly   258 QTTSNKLALEEV---VLE---ANEVETKDALEQFLN 287
            :.....::..||   |||   ..::..::||:.|||
  Rat   222 REPMGSMSSMEVNVDVLEQMDLMDLSDQEALDVFLN 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dysb	NP_001262023.1	TMPIT	94..>189	CDD:285135	22/94 (23%)
Dtnbp1	NP_001032753.1	Dysbindin	175..316	CDD:282316	30/84 (36%)
		Nuclear export signal. /evidence=ECO:0000250	243..256		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I4965
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370127at33208
OrthoFinder	1	1.000	-	-		FOG0007164
OrthoInspector	1	1.000	-	-		oto95980
orthoMCL	1	0.900	-	-		OOG6_107641
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7556
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870