Protein Alignment Indy and SLC13A1

DIOPT Version :9

• Sequence 1: NP_730363.2
• Gene: Indy / 40049
• FlyBaseID: FBgn0036816
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: XP_011514817.1
• Gene: SLC13A1 / 6561
• HGNCID: 10916
• Length: 651
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 207/654 - (31%)
• Similarity: 331/654 - (50%)
• Gaps: 129/654 - (19%)

  Fly    45 VVFLV-PLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTC 108
            |||.| .||.||::|..:.||  |.|.|.|:|.||:||||||.||:::|.:..|:.|||.|.:..
Human    16 VVFTVLVLLPLPIVLHTKEAE--CAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVA 78

  Fly   109 RLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAAC 173
            ..||||..::.:|.|.:|.::|..|||||:||:::.:||.:|..|..|.:..|.|||||:||.:.
Human    79 SAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTST 143

  Fly   174 TAMMCPIIQAVLE-------ELQAQGVCKINHEPQY-----QIVGGNKKNNEDEPPYPT------ 220
            .||:.||.:||::       |::|..:...|....:     :.|.|::.|...|...|.
Human   144 AAMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNND 208

  Fly   221 --------------------------------KITLCYYLG------------------------ 229
                                            |:.|.|.|.
Human   209 TGKISSKVELEKEEEESNQQRVFTGSWVRKRMKLLLAYTLESHLLNKTLTFGLVIPQVKPFQDVP 273

  Fly   230 --------------------------IAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDF 268
                                      |||:|::||..||.||:|||.|...:..|:.: ...::|
Human   274 LSKNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPD-CRCLNF 337

  Fly   269 PTFMFYSVPSMLVYTLLTFVFLQWHFMG-----LWR-PKSKEAQEVQRGREGADVAKKVIDQRYK 327
            .::..:|.|:.|:..||::::|||.|:|     ::: .|:|..|:        ....:||.|.|:
Human   338 GSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ--------KACAEVIKQEYQ 394

  Fly   328 DLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKD--IRNSMPTIFVVVMCFMLPANY 390
            .|||:...||..::|||.|.:::|:|.||...||:.|.:...  ..:|...:.:.::.|::||.
Human   395 KLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFATDSTVALLIGLLFFLIPAK- 458

  Fly   391 AFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGL 455
             .|...|..|..|....:| |||||..|:.:||.:..|:|||||||:|.::||::|.|||.|..|
Human   459 -TLTKTTPTGEIVAFDYSP-LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL 521

  Fly   456 KVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLP 520
            ..||..:::|:..|:...||..:||.|...:.:|:|:.::.||.::|||:::|:.|..|.||.||
Human   522 GSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLP 586

  Fly   521 VSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAAL 585
            |:.||||:|..|.:::..||..||:|..|:.:..:.:...|| :|...:|.::|.|     |.|:
Human   587 VANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW-IVPMFDLYTYPSW-----APAM 645

  Fly   586 GNKT 589
            .|:|
Human   646 SNET 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	182/584 (31%)
		dass	70..545	CDD:273267	181/582 (31%)
SLC13A1	XP_011514817.1	SLC13_permease	41..625	CDD:238535	184/595 (31%)
		CitT	48..633	CDD:223547	183/597 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146941
Domainoid	1	1.000	373	1.000	Domainoid score	I892
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2041
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870