DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy and Slc13a2

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_113934.1	Gene:	Slc13a2 / 65202	RGDID:	61920	Length:	587	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	219/575 - (38%)
Similarity:	348/575 - (60%)	Gaps:	37/575 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTC 108
            |:|..:|:..||:.|:.:..|..|.|.:::||:.|.||||||.||::.|||.||:||||.:.:.|
  Rat    15 LIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVC 79

  Fly   109 RLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAAC 173
            ..|||||.::|:||:|||:|||:.|||||:||:|:.|:|..|..|..|.::||.||||||||.|.
  Rat    80 IEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTAT 144

  Fly   174 TAMMCPIIQAVLEELQA--QGVCKINHEPQYQIV------------GGNKKNNEDEP-------- 216
            ||||.||..||||:||.  :.|...|:.|.:::.            .|...:...||
  Rat   145 TAMMVPIGHAVLEQLQGSKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEH 209

  Fly   217 -PYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSML 280
             .:...::||    |.|::|:||..|:.||..||..:|...:.|..:...::|.::..::.|:|:
  Rat   210 HRFSQGLSLC----ICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNVVNFASWFGFAFPTMI 270

  Fly   281 VYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIF 345
            :..||.:::||..|:|:...|:....|.:..|:.|  |.:||..:|:.|||||..|..|.:||:.
  Rat   271 ILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQA--AFQVIKTQYRLLGPMSFAEKTVTVLFVL 333

  Fly   346 MVVMYFTRKPGIFLGWADLLNSKDIRNSMPT-----IFVVVMCFMLPANYAFLRYCTRRGGPVPT 405
            :||::|||:||.|.||.|.:.:.:...||.:     ||:.::.|::|:....|....::.|.:..
  Rat   334 LVVLWFTREPGFFPGWGDTVFANEKGQSMASDGTVAIFISLVMFIIPSKIPGLMQDPKKPGKLKA 398

  Fly   406 GPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILV 470
              .|:::|||.:..|:||.:|.|||||||||:||:|||:::.:|:.|..|:.:|.|...:::.|:
  Rat   399 --PPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLL 461

  Fly   471 AVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANI 535
            ....|..:||||...:.:|:||.|:.||.:||||::||..||.|:||.|||:|||||:|..:..:
  Rat   462 IAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGL 526

  Fly   536 RTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH 590
            :..|||.||....||.::.:.:...:|.:.:: .|::||.||....:..|.|.::
  Rat   527 KVSDMARAGFLLNIIGVLAITLSINSWSIPIF-KLDTFPSWAHSNTSQCLLNPSN 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	200/504 (40%)
Indy	NP_730363.2	dass	70..545	CDD:273267	199/502 (40%)
Slc13a2	NP_113934.1	ArsB_NhaD_permease	7..560	CDD:304373	212/553 (38%)
Slc13a2	NP_113934.1	CitT	42..558	CDD:223547	203/523 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340608
Domainoid	1	1.000	365	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2965
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2018
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8961
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810