DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and Slc13a1

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_113839.1	Gene:	Slc13a1 / 58980	RGDID:	61919	Length:	595	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	202/591 - (34%)
Similarity:	325/591 - (54%)	Gaps:	76/591 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTC 108
            ||||.| |:.||:.|:....|..|.|:|.|:|.||:||||||.:|:::|.:.||:.|||||....
  Rat    15 LVVFTV-LVLLPLPLIIRSKEAECAYILFVIATFWITEALPLSITALLPGLMFPMFGIMSSTHVA 78

  Fly   109 RLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAAC 173
            ..||||..::.:|.|.:|.::|..|||||:|||::.:||.:|..|..|.:..|.|||||:||.:.
  Rat    79 SAYFKDFHLLLIGVICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTST 143

  Fly   174 TAMMCPIIQAVLEEL------------------QAQGVCKINHEPQYQIVG--GNKKNNEDEP-- 216
            .||:.||::||.:::                  .|||:     |....|:|  .|::..:.:|
  Rat   144 AAMVMPIVEAVAQQITSAEAEAEATQMTYFNESAAQGL-----EVDETIIGQETNERKEKTKPAL 203

  Fly   217 -----------------------PYPTK--------ITLCYYLGIAYASSLGGCGTIIGTATNLT 250
                                   .|.:|        :.||    |||:|::||..||.||:|||.
  Rat   204 GSSNDKGKVSSKMETEKNTVTGAKYRSKKDHMMCKLMCLC----IAYSSTIGGLTTITGTSTNLI 264

  Fly   251 FKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGA 315
            |...:..|:.: ...::|.::..:|.|..::..||::::|||.|:|....:..:..:.:..:|.|
  Rat   265 FSEHFNTRYPD-CRCLNFGSWFLFSFPVAVILLLLSWIWLQWLFLGFNFKEMFKCGKTKTLKEKA 328

  Fly   316 DVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKD--IRNSMPTIF 378
              ..:||.|.|:.||||...||..:::||.|.:::|:|.||...||:.|.:...  :.:|...:.
  Rat   329 --CAEVIKQEYEKLGPMRYQEIVTLVIFIVMALLWFSRDPGFVTGWSVLFSEYPGYVTDSTVALV 391

  Fly   379 VVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSG 443
            ..::.|::||..  |...|..|..:....:| |||||..|:.:||.:..|:|||||||:|.:.||
  Rat   392 AGILFFLIPAKK--LTKMTSTGDIIAFDYSP-LITWKEFQSFMPWDIAILVGGGFALADGCQVSG 453

  Fly   444 MAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILP 508
            ::..||:.|..|..||..:::|:..|:...||..:||.|...|:.|:|:.::.||.::||:::||
  Rat   454 LSSWIGSKLSPLGSLPVWLIILISSLIVTSLTEVASNPATITILFPILSPLAEAIHVNPLHILLP 518

  Fly   509 AGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYP--NLN 571
            :.|..|.||.|||:.||||:|..|.:::..||..||:|..|:.:..:.:...||   :.|  ||:
  Rat   519 STLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNILGVAVVMLGMFTW---IEPMFNLH 580

  Fly   572 SFPEWA 577
            .:|.||
  Rat   581 EYPSWA 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	180/531 (34%)
Indy	NP_730363.2	dass	70..545	CDD:273267	179/529 (34%)
Slc13a1	NP_113839.1	SLC13_permease	38..567	CDD:238535	183/543 (34%)
		CitT	40..573	CDD:223547	184/550 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..218		2/27 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340611
Domainoid	1	1.000	365	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2018
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8961
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870