DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy and Slc13a1

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_062354.2	Gene:	Slc13a1 / 55961	MGIID:	1859937	Length:	594	Species:	Mus musculus

Alignment Length:	589	Identity:	202/589 - (34%)
Similarity:	326/589 - (55%)	Gaps:	73/589 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTC 108
            ||||.: |:.||:.|:....|.:|.|:|.|:||||:||||||.:|:::|.:.||:.|||.|.|..
Mouse    15 LVVFTI-LVFLPLPLIIRTKEAQCAYILFVIAIFWITEALPLSITALLPGLMFPMFGIMRSSQVA 78

  Fly   109 RLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAAC 173
            ..||||..::.:|.|.:|.::|..|||||:|||::.:||.:|..|..|.:..|.|||||:||.:.
Mouse    79 SAYFKDFHLLLIGVICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTST 143

  Fly   174 TAMMCPIIQAVLE-------ELQAQGVCKINHEPQY-----QIVGGNKKNNEDEPPYPT------ 220
            .||:.||::||.:       |.:|..:...|....:     :.|.|.:.|.:.|...|.
Mouse   144 AAMVMPIVEAVAQQIISAEAEAEATQMTYFNESAAHGLDIDETVIGQETNEKKEKTKPAPGSSHD 208

  Fly   221 --KIT--------------------------LCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEA 257
              |::                          :|  |.:||:|::||..||.||:|||.|...:..
Mouse   209 KGKVSRKMETEKNAVTGAKYRSRKDHMMCKLMC--LSVAYSSTIGGLTTITGTSTNLIFSEHFNT 271

  Fly   258 RFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMG----LWR-PKSKEAQEVQRGREGADV 317
            |:.: ...::|.::..:|.|..|:..||::::|||.::|    ::: .|:|..:|        ..
Mouse   272 RYPD-CRCLNFGSWFLFSFPVALILLLLSWIWLQWLYLGFDFKMFKCGKTKTLKE--------KA 327

  Fly   318 AKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKD--IRNSMPTIFVV 380
            ..|||.|.|:.||||...||..:::||.|.:::|:|.||...||:.|.:...  :.:|...:...
Mouse   328 CAKVIKQEYEKLGPMRYQEIVTLVIFIVMALLWFSRDPGFVTGWSVLFSEYPGYVTDSTVALVAG 392

  Fly   381 VMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMA 445
            ::.|::||..  :...|..|..:....|| |||||..|:.:||.:..|:|||||||:|.:.||::
Mouse   393 ILFFLIPAKK--VTKMTSAGEIIAFDYTP-LITWKEFQSFMPWDIAILVGGGFALADGCQVSGLS 454

  Fly   446 KLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAG 510
            ..||:.|..|..||..:::|:..|:...||..:||.|...|:.|:|:.::.||:::||.::||:.
Mouse   455 NWIGSKLSPLGSLPVWLIILISSLIVTSLTEVASNPATITILFPILSPLAEAIQVNPLQILLPST 519

  Fly   511 LACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYP--NLNSF 573
            |..|.||.|||:.||||:|..|.:::..||..||:|..|:.:..:.:...||   :.|  ||:.:
Mouse   520 LCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNILGVAVVMLGMFTW---IEPMFNLHEY 581

  Fly   574 PEWA 577
            |.||
Mouse   582 PSWA 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	181/529 (34%)
Indy	NP_730363.2	dass	70..545	CDD:273267	180/527 (34%)
Slc13a1	NP_062354.2	CitT	13..572	CDD:223547	196/574 (34%)
		SLC13_permease	38..566	CDD:238535	184/541 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..226		4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836886
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870