DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy and slc13a5a

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_005161489.1	Gene:	slc13a5a / 503788	ZFINID:	ZDB-GENE-030131-4628	Length:	582	Species:	Danio rerio

Alignment Length:	583	Identity:	223/583 - (38%)
Similarity:	340/583 - (58%)	Gaps:	62/583 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WK---GLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIM 102
            ||   .|::|..|.|.||:.|:....|..|.|::::||::|.||.|||.||:::|.|.||:..||
Zfish    11 WKMKNTLILFCTPFLLLPLPLVIGSKEAGCAYVVVLMAVYWCTEVLPLAVTALLPAVLFPLFRIM 75

  Fly   103 SSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMW 167
            .|...|..|.|||.::|:||:|||:|||:.|||||:||||:.:||..|..|..|.:.||.|||||
Zfish    76 ESKDVCMQYLKDTNMLFLGGLMVAVAVEHWNLHKRIALRVLLLVGVRPALLMLGFMGVTAFLSMW 140

  Fly   168 ISNAACTAMMCPIIQAVLEELQ--AQGVCKINHEPQYQIVGGNKKNNEDEPPYPTK--------- 221
            |||.|.||||.||:|||||:|.  ||       :.|..|....:|:.|.:|..|.:
Zfish   141 ISNTATTAMMVPIVQAVLEQLNNTAQ-------QEQSSIPETEEKSTEKQPESPGEEKVVLNGDN 198

  Fly   222 -----------------------ITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNST 263
                                   :|||    :.||:|:||..|:.||..||...|.....|.::.
Zfish   199 FSMESDPEEHSREAEERLKMSKGLTLC----VCYAASIGGTATLTGTGPNLVLMGQMSQLFPDNP 259

  Fly   264 EQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKD 328
            :.::|.::..::.|:|::...|.:::||..|:|:...|:.....|:..:|.|  |..||.:.::.
Zfish   260 DIINFASWFGFAFPNMIIMLTLAWLWLQIVFLGINFKKTWGCGTVKTEKEIA--AYNVIKEEHRS 322

  Fly   329 LGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKD---IRNSMPTIFVVVMCFMLPANY 390
            ||||:..|:.|:.|||.:||::|||.||...|||....:.|   :.::...:||..:.|:.|:..
Zfish   323 LGPMTFGELSVLALFILLVVLWFTRDPGFVDGWATRFFNADKEFVTDATVAVFVAALLFVFPSKP 387

  Fly   391 AFLRYC---TRRGGPVP---TGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIG 449
            .  |.|   |.....||   :||||:|:|||..|.|:||.::.|||||||||:||:.||::|.:|
Zfish   388 P--RLCFWRTESFDTVPQQESGPTPALLTWKVTQKKMPWSIILLLGGGFALAKGSEISGLSKWLG 450

  Fly   450 NALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACS 514
            :.:..|:.:|...:.:|:.|:....|..:||||.|.:.:|:||.||.:|.::|||:::|..|:.|
Zfish   451 DQMSPLQSIPPWAIAIVICLMIATFTECTSNVATATLFLPILASMSQSIGVNPLYVMVPCTLSAS 515

  Fly   515 MAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWA 577
            .||.|||:|||||:|..|..::..|||..||...||.|:::.:...:||..:: :|::||.||
Zfish   516 FAFMLPVATPPNAIVFSYGYLKVSDMAKTGIVMNIIGILSITLAINSWGRAIF-SLDTFPSWA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	200/519 (39%)
Indy	NP_730363.2	dass	70..545	CDD:273267	199/517 (38%)
slc13a5a	XP_005161489.1	ArsB_NhaD_permease	35..570	CDD:304373	209/550 (38%)
slc13a5a	XP_005161489.1	CitT	43..563	CDD:223547	204/534 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580401
Domainoid	1	1.000	381	1.000	Domainoid score	I793
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1908
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910