DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and Slc13a4

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001012639.1	Gene:	Slc13a4 / 503568	RGDID:	1359715	Length:	689	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	197/615 - (32%)
Similarity:	316/615 - (51%)	Gaps:	112/615 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALA 128
            |..|.|:|||.|::||:||:||...:::|...:|..|::.|.:....|||:|.::.:|.|.||.|
  Rat    95 EAACAYVLLVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSSEVAAEYFKNTTLLLVGVICVAAA 159

  Fly   129 VEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGV 193
            ||..|||||:|||::.:.|..|..|....:..|..||||:||.:.|||:.||::|||:||
  Rat   160 VEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQEL----- 219

  Fly   194 CKINHEPQYQIVGGNKKN----------------------NED---------------------- 214
              ||.|.: |:|.||...                      |||
  Rat   220 --INAEEE-QLVAGNSSTEEAELMGVDVSNRQTSVELIFVNEDTSAADFTSLMQNKNLNGVPMVT 281

  Fly   215 -------------------EPPYPT-------------------KITLCYYLGIAYASSLGGCGT 241
                               :|..||                   .:..|..|.|:||:::||..|
  Rat   282 KSIKTANQQQQKKQHQSQEKPGVPTPSSKNQELNKKKYRSHHDQMVCKCLSLSISYAATIGGLTT 346

  Fly   242 IIGTATNLTFKGIYEARFKN---STEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGL-WRPKS 302
            ||||:|:|    |:...|.|   :.|.::|.|:..:|.|..|:..::::.::.|.|:|. ::...
  Rat   347 IIGTSTSL----IFLEHFNNQYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETC 407

  Fly   303 KEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNS 367
            ..:::.:..||  :::::.|.:.|:.||.:|..|:.....||.|.|::|||:||...||......
  Rat   408 SLSKKKKTRRE--ELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPGWDSFFEK 470

  Fly   368 KDIR-NSMPTIFVVVMCFMLPANY-AFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLG 430
            |..| ::..::|:..:.|::||.. .|.:.....|.....|..| :||||..|..:||.:|.|:|
  Rat   471 KGYRTDATVSVFLGFLLFLIPAKKPCFGKKSDGAGQEASRGIEP-IITWKDFQKTMPWEIVILVG 534

  Fly   431 GGFALAEGSKQSGMAKLIGNALIGLKVLPN-SVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEM 494
            ||:|||.|||.||::..||:.::.|..||. ::.||..:||:: :|.|.||.|...|.:|:|..:
  Rat   535 GGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSI-VTEFVSNPATITIFLPILCTL 598

  Fly   495 SLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFC 559
            |..:.|:|||.::|..::.|.|..|||..||||:|..|.:.:.|||..||:|..:|.::.:.|..
  Rat   599 SETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI 663

  Fly   560 QTWGLVVYPNLNSFPEWAQIYAAAALGNKT 589
            .|||:.:: :|::||.||::      ||.|
  Rat   664 NTWGVSLF-HLDTFPAWAKV------GNIT 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	180/565 (32%)
Indy	NP_730363.2	dass	70..545	CDD:273267	179/563 (32%)
Slc13a4	NP_001012639.1	SLC13_permease	99..667	CDD:238535	185/583 (32%)
Slc13a4	NP_001012639.1	dass	101..666	CDD:273267	183/580 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340602
Domainoid	1	1.000	365	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2018
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8961
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870