DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and Indy-2

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001027201.1	Gene:	Indy-2 / 3772456	FlyBaseID:	FBgn0260466	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	262/563 - (46%)
Similarity:	382/563 - (67%)	Gaps:	17/563 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EIGEQPQPPV-KCSNFFANHWKGLVVFLVPLLCLPVMLL---NEGAEFRCMYLLLVMAIFWVTEA 82
            |.|||.:..: :|..|   ||:|....::||:.||:::.   .:.|||:|::|::.||:.|:||.
  Fly     3 EPGEQRKFVLGRCCIF---HWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITET 64

  Fly    83 LPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVG 147
            ||:|||::.|:|..|::|::::...|:.||.||:|:|:||::|||.:||.|||.|:|||||:|||
  Fly    65 LPIYVTALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVG 129

  Fly   148 CSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNN 212
            .|||||..||:.|:.|:.:||||:|.|||||||::|::.||....:..:....:.:.|      .
  Fly   130 GSPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPV------E 188

  Fly   213 EDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVP 277
            |.|||:|:|||:.:|.|||||||:||.||:|||.|||.|:|||..||..||.::.|..|||||:|
  Fly   189 EGEPPHPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIP 253

  Fly   278 SMLV--YTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVM 340
            .|::  .||:...||..| |||:||.||..:.:........:.:.|:.||:.||||||.||||:.
  Fly   254 LMVIVNVTLVIIAFLITH-MGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMA 317

  Fly   341 ILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPT 405
            |.|.||:|:..|||||...||:||:|.|.:.::....|:|::.|.||..|.|.:||..: ||...
  Fly   318 IAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLSFIVLLIFALPTQYTFFKYCCGK-GPFTA 381

  Fly   406 GPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILV 470
            ....::::|:::...:||||:||||||||||..|:::|:..:|..|:..|..|||.|:..:..::
  Fly   382 QAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVL 446

  Fly   471 AVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANI 535
            |.|.:||::||.:|||::|:|.|||||:|:|||.|.|||.|..||.:.|||||||||:|..||:|
  Fly   447 ANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHI 511

  Fly   536 RTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQ 578
            :||..|..||.||||.|....|...||||:::|...|||:||:
  Fly   512 KTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	227/478 (47%)
Indy	NP_730363.2	dass	70..545	CDD:273267	227/476 (48%)
Indy-2	NP_001027201.1	ArsB_NhaD_permease	50..533	CDD:304373	234/490 (48%)
Indy-2	NP_001027201.1	dass	52..532	CDD:273267	234/487 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448679
Domainoid	1	1.000	215	1.000	Domainoid score	I747
eggNOG	1	0.900	-	-		E1_COG0471
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I1174
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm6448
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
	9	8.890