Protein Alignment Indy and SLC13A5

DIOPT Version :10

• Sequence 1: NP_730363.2
• Gene: Indy / 40049
• FlyBaseID: FBgn0036816
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 217/577 - (37%)
• Similarity: 337/577 - (58%)
• Gaps: 54/577 - (9%)

  Fly    37 FANHWKGLVV-FLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMG 100
            :.:.:|..|: |:.|||.||:::|......||.|::::|||:|.||.:||.|||::|::.||:..
Human     7 YVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQ 71

  Fly   101 IMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLS 165
            |:.|.|.|..|.|||.::|:||::||:|||..|||||:|||.:..||..|.||..|.:.||..||
Human    72 ILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLS 136

  Fly   166 MWISNAACTAMMCPIIQAVLEELQAQGVC-----------KINHEPQYQIV--GGNKKNNEDE-- 215
            |||||.|.||||.||::|:|::::|....           |....|..|::  |......||:
Human   137 MWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQER 201

  Fly   216 PPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSML 280
            ......:|||    |.||:|:||..|:.||..|:...|.....|.:|.:.::|.::..::.|:||
Human   202 KRLCKAMTLC----ICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNML 262

  Fly   281 VYTLLTFVFLQWHFM----------GLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIH 335
            |..|..:::||:.:|          ||...|:::|            |.||:.:.|:.|||:|..
Human   263 VMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKA------------ALKVLQEEYRKLGPLSFA 315

  Fly   336 EIQVMILFIFMVVMYFTRKPGIFLGWADLL----NSKDIRNSMPTIFVVVMCFMLPA---NYAFL 393
            ||.|:|.|..:|:::|:|.||...||..:.    .:|.:.::...|||..:.|::|:   .:.|
Human   316 EINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNF- 379

  Fly   394 RYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVL 458
            |..|......|..| |.|:.||..|.|||||:|.|||||||||:||:.||::..:|..:..|..:
Human   380 RSQTEEERKTPFYP-PPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAV 443

  Fly   459 PNSVLLLVV-ILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVS 522
            |.:.:.|:: :||||| |..:||||...:.:|:.|.||.:|.::|||::||..|:.|.||.|||:
Human   444 PPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVA 507

  Fly   523 TPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQI 579
            |||||:|..|.:::..||...|:...||.:..:|:...|||..:: :|:.||:||.:
Human   508 TPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWANV 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	CitT	120..545	CDD:440239	170/457 (37%)
SLC13A5	NP_808218.1	CitMHS	<11..164	CDD:460985	75/152 (49%)
		CitT	91..547	CDD:440239	174/474 (37%)