Protein Alignment Indy and SLC13A5

DIOPT Version :9

• Sequence 1: NP_730363.2
• Gene: Indy / 40049
• FlyBaseID: FBgn0036816
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_808218.1
• Gene: SLC13A5 / 284111
• HGNCID: 23089
• Length: 568
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 217/577 - (37%)
• Similarity: 337/577 - (58%)
• Gaps: 54/577 - (9%)

  Fly    37 FANHWKGLVV-FLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMG 100
            :.:.:|..|: |:.|||.||:::|......||.|::::|||:|.||.:||.|||::|::.||:..
Human     7 YVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQ 71

  Fly   101 IMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLS 165
            |:.|.|.|..|.|||.::|:||::||:|||..|||||:|||.:..||..|.||..|.:.||..||
Human    72 ILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLS 136

  Fly   166 MWISNAACTAMMCPIIQAVLEELQAQGVC-----------KINHEPQYQIV--GGNKKNNEDE-- 215
            |||||.|.||||.||::|:|::::|....           |....|..|::  |......||:
Human   137 MWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQER 201

  Fly   216 PPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSML 280
            ......:|||    |.||:|:||..|:.||..|:...|.....|.:|.:.::|.::..::.|:||
Human   202 KRLCKAMTLC----ICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNML 262

  Fly   281 VYTLLTFVFLQWHFM----------GLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIH 335
            |..|..:::||:.:|          ||...|:::|            |.||:.:.|:.|||:|..
Human   263 VMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKA------------ALKVLQEEYRKLGPLSFA 315

  Fly   336 EIQVMILFIFMVVMYFTRKPGIFLGWADLL----NSKDIRNSMPTIFVVVMCFMLPA---NYAFL 393
            ||.|:|.|..:|:::|:|.||...||..:.    .:|.:.::...|||..:.|::|:   .:.|
Human   316 EINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNF- 379

  Fly   394 RYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVL 458
            |..|......|..| |.|:.||..|.|||||:|.|||||||||:||:.||::..:|..:..|..:
Human   380 RSQTEEERKTPFYP-PPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAV 443

  Fly   459 PNSVLLLVV-ILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVS 522
            |.:.:.|:: :||||| |..:||||...:.:|:.|.||.:|.::|||::||..|:.|.||.|||:
Human   444 PPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVA 507

  Fly   523 TPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQI 579
            |||||:|..|.:::..||...|:...||.:..:|:...|||..:: :|:.||:||.:
Human   508 TPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIF-DLDHFPDWANV 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	194/509 (38%)
		dass	70..545	CDD:273267	193/507 (38%)
SLC13A5	NP_808218.1	ArsB_NhaD_permease	31..552	CDD:419678	203/539 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146947
Domainoid	1	1.000	373	1.000	Domainoid score	I892
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2041
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8490
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	LDO	PTHR10283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2228
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840