DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and Slc13a5

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_006246664.1	Gene:	Slc13a5 / 266998	RGDID:	631374	Length:	610	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	209/620 - (33%)
Similarity:	345/620 - (55%)	Gaps:	73/620 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GEQPQPPVKCSNF------------------------FANHWKGLVV-FLVPLLCLPVMLLNEGA 63
            ||:|:.|....:|                        :...:|..|: |..|:|.||:::|....
  Rat     8 GEKPEKPTGWWSFSSGTLRSPGESSLSPFHAMASAKTYVTKFKSFVILFFAPILLLPLIILVPDK 72

  Fly    64 EFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALA 128
            ..||.|::::|||:|.|:.:|:.:||::|::.||::.::.|.|.|..|..||.::|:|.::||.|
  Rat    73 FARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATA 137

  Fly   129 VEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGV 193
            ||...||||:|||::..||..|.||..|.:.||.||||||||.|.||||.||::|:||::.|..|
  Rat   138 VERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNV 202

  Fly   194 C--------------KINHEPQYQIV----GGNKKNNEDEPPYPTKITLCYYLGIAYASSLGGCG 240
            .              |.:..|..|:|    ...|:.:|:.......:.||    :.||:|:||..
  Rat   203 AVDASQRTMELLDKNKASELPGSQVVFEDPSVQKQEDEETKNMYKAMNLC----VCYAASIGGTA 263

  Fly   241 TIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEA 305
            |:.||..|:...|..:..|.:|.:.|:|.::..:::|:||:..::.:::|...:|   ||..|:.
  Rat   264 TLTGTGPNVVLLGQMQELFPDSKDVMNFASWFAFALPNMLLMLVMAWLWLLCFYM---RPNLKKT 325

  Fly   306 QEVQRGREGAD---VAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLL-- 365
            . :..||:..|   :|.||:.:.|:.|||:|..|..|:..|..:::::|:|.||...||..:.
  Rat   326 C-ICCGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILWFSRDPGFMPGWLSIAWI 389

  Fly   366 --NSKDIRNSMPTIFVVVMCFMLPA---NYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGL 425
              |:|.:.::...|||.::.|::|:   .:.|.|. |......|..| |.|:.||..|.|||||:
  Rat   390 EGNTKHVTDATVAIFVAILLFIVPSQKPKFNFSRQ-TEEERKTPFYP-PPLLNWKVTQEKVPWGI 452

  Fly   426 VFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPV 490
            |.|||||||:|:|.:.||:::.:...:..|..:..:::.|::..:....|..:||||...:.:|:
  Rat   453 VLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPI 517

  Fly   491 LAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITL 555
            .|.|:.:|.|||||:::|..|:.|:||.|||:|||||:|..|.:::..||...|:...|:.|.::
  Rat   518 FASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASV 582

  Fly   556 FVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH 590
            |:...|||..|: ||:.||:||         |.||
  Rat   583 FLSVNTWGRAVF-NLDKFPDWA---------NLTH 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	177/504 (35%)
Indy	NP_730363.2	dass	70..545	CDD:273267	176/502 (35%)
Slc13a5	XP_006246664.1	CitT	71..589	CDD:223547	183/527 (35%)
Slc13a5	XP_006246664.1	ArsB_NhaD_permease	72..596	CDD:304373	187/534 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340599
Domainoid	1	1.000	365	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2018
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8961
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	LDO	PTHR10283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810