DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and SPBC3B8.04c

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_596410.1	Gene:	SPBC3B8.04c / 2540279	PomBaseID:	SPBC3B8.04c	Length:	867	Species:	Schizosaccharomyces pombe

Alignment Length:	588	Identity:	136/588 - (23%)
Similarity:	239/588 - (40%)	Gaps:	157/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPPLDIKMEIEIGEQPQPPVKCSNFFANHWKGL---VVFLVPLLCLPVMLLNEGAEFRCMYLLLV 73
            ||...||.:..:...|    :|  ||.:....|   :|..:.||..||  ::...:..|:.||::
pombe   384 PPYFTIKTKFGVFRIP----RC--FFNSTIATLITIIVIFILLLSFPV--IDNREQNNCLALLVM 440

  Fly    74 MAIFWVTEALPLYVTS-MIPIVAF-----------PIMGIMSSDQTCRLYFKDTLVMFMGGIMVA 126
            :::.|.|||:||:||| ::|.:..           |:.|..|:.......:..|:|:.:||..:|
pombe   441 VSLLWATEAIPLFVTSFLVPFMTVFLKILRDENGSPLSGKESTKVIFSSMWNPTIVLLLGGFTIA 505

  Fly   127 LAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQ 191
            .|:...::.||||..::...|..||.:....:.|.||.||||||.|...:...|||.:|..|.|
pombe   506 AALSKYHIAKRLATSILAHAGRKPRSVLLTNMFVAMFASMWISNVAAPVLCFSIIQPLLRNLPA- 569

  Fly   192 GVCKINHEPQYQIVGGNKKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYE 256
                   |..:                 .||.:   :|||.||::||..:.|.:..|:
pombe   570 -------ESDF-----------------AKILI---VGIALASNVGGIASPISSPQNI------- 600

  Fly   257 ARFKNSTEQMDFPTFMFYSVPSML-----VYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGRE--- 313
            ...:|......:..:...|:|..|     ::.||:|..|:...:.|  .|.:..::...|.:
pombe   601 VALQNMDPAAGWGEWFAVSIPVSLLCIFSIWFLLSFGLLKDEHITL--AKIRSTKDTFTGVQWFI 663

  Fly   314 -----GADV---AKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKDI 370
                 |..|   .::..|:.:.|:|          ::.:..::::|         ...||..:|.
pombe   664 SIVTIGTIVLWCLERRFDEVFGDMG----------VIALVPIIVFF---------GTGLLTKEDF 709

  Fly   371 RNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFAL 435
            .|.:.|:.|:.|                                                ||.||
pombe   710 NNFLWTVIVLAM------------------------------------------------GGVAL 726

  Fly   436 AEGSKQSGMAKL----IGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEM-S 495
            .:....||:.:|    ||||:..|....   :||:...:.:.:::|.|::..|.:::|::.|: |
pombe   727 GKVVSSSGLLELIALKIGNAVSSLNTFR---VLLIFSALTLVVSSFISHIVAAMVVLPIVHEVGS 788

  Fly   496 LAIEIHPLYLILPAGLACSMAFHLPVSTPPNALV------AGYANIRTKDMAIAGIGPTIITIIT 554
            ...:.||...:|.:|:.||:|..||.|..||...      ||...::..|...|||..|:|:.:.
pombe   789 RLADPHPRLFVLASGMMCSLAMALPTSGFPNMTAIMMENEAGKRYLKVSDFLKAGIPATLISFVI 853

  Fly   555 LFV 557
            |.:
pombe   854 LLL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	116/515 (23%)
Indy	NP_730363.2	dass	70..545	CDD:273267	116/513 (23%)
SPBC3B8.04c	NP_596410.1	COG5408	1..301	CDD:227695
		SPX_PHO87_PHO90_like	2..282	CDD:269899
		CitT	409..861	CDD:223547	128/557 (23%)
		SLC13_permease	435..858	CDD:238535	121/529 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	130	1.000	Domainoid score	I1327
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I1393
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		oto100620
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2228
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.890