DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and nac-1

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_510473.2	Gene:	nac-1 / 181585	WormBaseID:	WBGene00003517	Length:	582	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	188/560 - (33%)
Similarity:	317/560 - (56%)	Gaps:	47/560 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WKGLVVFLVPLLCLPVMLLNE--GAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMS 103
            |..|::| .|||    |.:.:  |.:.:|:|.:.||..:||.|||||.:|:.||::.||:.|||.
Worm    21 WGALLIF-SPLL----MFVGDSHGLQAKCLYCVAVMGSYWVFEALPLAITAFIPMILFPLFGIMR 80

  Fly   104 SDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWI 168
            |::..|.|..||..:||||:|||||||.|.||.|:||.|::.||..|.|:..|.:.||.||||||
Worm    81 SEEVARAYLPDTCFLFMGGLMVALAVEKCELHARVALFVLKTVGSEPARVMAGFMGVTGFLSMWI 145

  Fly   169 SNAACTAMMCPIIQAVLEELQAQ-------GVCKINHEPQYQIVGGNKK------NNEDE----- 215
            ||.|.||:|.||:|:|:.||.:.       .:|:.:|....:...|.::      |||.:
Worm   146 SNTATTALMVPILQSVITELVSNHRMEDLVALCEAHHNSSRKHSVGMRRLSLPNENNEIKREEMD 210

  Fly   216 ---PPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVP 277
               .|...|:.....|.:.:::::||..||.|||:||...|.....|..:...::|.:::.::.|
Worm   211 TAMSPREQKMAKGLMLSVCFSANIGGAATITGTASNLVLVGQLNELFPGADTGVNFLSWLIFAFP 275

  Fly   278 SMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMIL 342
              :|:..|.:.:...:.:.|     ::|.      :|:.:..:.:.|:|.:|...|..|:.|:..
Worm   276 --MVFCCLIYCWCVLYLLYL-----RDAP------KGSIIVTRKLQQKYNELHAFSFAEMAVIFC 327

  Fly   343 FIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGP 407
            |..::|::..|:|.:..||.::...:.:.::...:|:|::.|.||.     :..:.||.......
Worm   328 FALLLVLWILREPQVVPGWGEMFKDEFVSDATSAMFIVILLFTLPE-----KLPSSRGSSEQRKA 387

  Fly   408 TPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAV 472
            :..|:.|..:|.:.||.::||||||||||.|.|:||::..||..:..|.|..:::::|:.|:::|
Worm   388 SSGLLDWATVQDRFPWSVLFLLGGGFALAAGVKESGLSHDIGAIMRYLDVFNHNIIMLICIIISV 452

  Fly   473 FLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRT 537
            .||...||..||:|.||::||::.::||.||..:||..::.|.||.|||:|||||:|.....::.
Worm   453 TLTNVCSNTVIASIFIPIVAELARSLEIDPLNFMLPVTISASFAFLLPVATPPNAIVFSSGYLKV 517

  Fly   538 KDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWA 577
            .||.::|:..|:..::...:....|...|: ||:.||:||
Worm   518 FDMFVSGLCVTLGCVVLSMLNMLLWAGFVF-NLHLFPQWA 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	169/497 (34%)
Indy	NP_730363.2	dass	70..545	CDD:273267	168/495 (34%)
nac-1	NP_510473.2	CitT	19..547	CDD:223547	181/548 (33%)
nac-1	NP_510473.2	SLC13_permease	45..544	CDD:238535	172/516 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I685
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2965
Inparanoid	1	1.050	329	1.000	Inparanoid score	I1442
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm4842
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	LDO	PTHR10283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2228
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.910