DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and B0285.6

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001366690.1	Gene:	B0285.6 / 175563	WormBaseID:	WBGene00007138	Length:	574	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	184/576 - (31%)
Similarity:	307/576 - (53%)	Gaps:	40/576 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FFANHWKGLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMG 100
            ||...|    :.|.||:..|::..  |.|.:|.:::|.|:.:||.|.:||.|||.||::|.|.:|
Worm    14 FFPTLW----LILAPLILSPLLFF--GQEGKCAFVILTMSCYWVAEVVPLAVTSFIPMIALPFLG 72

  Fly   101 IMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLS 165
            |:|..:....||.||.::|...:|::||||.|.||||:||:::..||..|..|..|.:::|.|:|
Worm    73 IVSIKEVAPKYFADTNIVFFNSLMLSLAVEECQLHKRIALKMLTYVGTRPHWLMAGFMIITSFIS 137

  Fly   166 MWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNNEDEPPYPTK--------- 221
            :|||:.||.|:|.||..|:|||:.   :.|:..|.:...:...|..::::|....|
Worm   138 LWISDTACCALMAPIAYALLEEIM---IPKMRPEEKENEIEVMKIFDKEDPEEKEKKKLDTSRLS 199

  Fly   222 -----ITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLV 281
                 |..|..|.:|:||.:||.|||..|..||.|:...|..|.|....:.:.::|.:::|.|:.
Worm   200 VRDRGICKCMMLLVAHASLIGGTGTINSTGPNLIFRDNIEKNFPNEDHGISYLSWMAFAIPPMIF 264

  Fly   282 YTLLTFVFLQW------HFMGLWR-PKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQV 339
            |...::..:|.      |.||::| |...|.||       .:|||:.:.:.|..||||:..|...
Worm   265 YMFSSWFIVQLQFLGPRHLMGMFREPTETEKQE-------EEVAKRAVWKSYDQLGPMTWAEKST 322

  Fly   340 MILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVP 404
            :::|:..|:.:.:..|.:..||:||.....:.:|...:..|.:.|:.|......| ..|:....|
Worm   323 LVIFVLAVLSWVSSDPKVIPGWSDLFRKGYVTDSCSGLVAVFLLFIWPKKKPDFR-IFRKDKSRP 386

  Fly   405 TGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIG-LKVLPNSVLLLVVI 468
            :.....||.|..::.:.||.::.|||.|||:::..:.||::.||..:|.. :..:|..|:.:::.
Worm   387 SVRQEPLIDWDCVRRRFPWSIILLLGAGFAISDAVRVSGLSSLIACSLNSTISKMPFFVMQIILS 451

  Fly   469 LVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYA 533
            :|.|.:|.||:|.|.|:|.||:..:|:.|:..||||..:|..:..|.:|.||::||.||:|....
Worm   452 IVVVVMTEFSTNSATASIFIPISFKMAEAVGAHPLYFSIPTAIGPSFSFMLPMATPANAIVYETK 516

  Fly   534 NIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKT 589
            .||..||...|:...|..|....:...||...:: |:.::|::|..:|....||.:
Worm   517 TIRMIDMVSCGVFLNIFCIAITAINMNTWAFWLF-NMGTYPDYALRHATNMTGNSS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	163/498 (33%)
Indy	NP_730363.2	dass	70..545	CDD:273267	163/496 (33%)
B0285.6	NP_001366690.1	ArsB_NhaD_permease	42..540	CDD:419678	166/508 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.875	Normalized mean entropy	S3349
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm4842
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710