DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy and Slc13a3

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_473396.1	Gene:	Slc13a3 / 114644	MGIID:	2149635	Length:	600	Species:	Mus musculus

Alignment Length:	585	Identity:	204/585 - (34%)
Similarity:	332/585 - (56%)	Gaps:	45/585 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTC 108
            ||:.||||..||::......|.||:|::|:||::|.||||||.||:::||:.||.|||:.|.:.|
Mouse    18 LVLLLVPLALLPILFALPPKEGRCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVC 82

  Fly   109 RLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAAC 173
            ..||.||..:|:.|:::|.|:|..|||:|:||:|:.:||..|.||..|:::.|.|||||:||.|.
Mouse    83 PQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTAS 147

  Fly   174 TAMMCPIIQAVLEEL---------------------QAQGVCKINHEPQY--QIVGGNKKNNE-- 213
            ||||.||..|:|:.|                     |..|:..:..|.|:  ...||:.::.|
Mouse   148 TAMMLPIASAILKSLFGQREARKDLPREGDESTAAVQGNGLRTVPTEMQFLASSEGGHTEDAEAP 212

  Fly   214 -------DEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTF 271
                   .|..:...|...:.:.|.|::|:||..|:.|||.||...|..::.|. ..:.::|.::
Mouse   213 MELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFP-QCDVVNFGSW 276

  Fly   272 MFYSVPSMLVYTLLTFVFLQWHFMGL-WRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIH 335
            ..::.|.||::.|:.::::.:.:.|: ||...|:..:::...|  |.||.||.:.:::|||:...
Mouse   277 FIFAFPLMLLFLLVGWLWISFLYGGMSWRSWRKKKSKIRADAE--DQAKAVIQEEFQNLGPIKFA 339

  Fly   336 EIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRG 400
            |..|.|||....::.|:|.|....|||.|.....:.:::..:.:|.:.|..|:....|::..  .
Mouse   340 EQAVFILFCTFAILLFSRDPKFIPGWASLFAPGFVSDAVTGVAIVTILFFFPSQKPSLKWWF--D 402

  Fly   401 GPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLL 465
            ...|...|..|::||..|..|||.::.|||||||:|:|.::||::..||..|..|:.:|..:.:|
Mouse   403 FKAPNSETEPLLSWKKAQETVPWNIILLLGGGFAMAKGCEESGLSAWIGGQLHPLEHVPPLLAVL 467

  Fly   466 VVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVA 530
            ::.:|..|.|.|:||.|...|.:|||||:::.:.:|||||::|..:.||.||.||||||||::..
Mouse   468 LITVVIAFFTEFASNTATIIIFLPVLAELAIRLHVHPLYLMIPGTVGCSYAFMLPVSTPPNSIAF 532

  Fly   531 GYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAA------AALGNKT 589
            ...::..|||...|:...::.::.|.:...||...:: .|.:||:||..:||      .||.|.|
Mouse   533 STGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIF-QLGTFPDWANTHAANATALPPALTNNT 596

Fly 590 589
Mouse 597 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	178/509 (35%)
Indy	NP_730363.2	dass	70..545	CDD:273267	177/507 (35%)
Slc13a3	NP_473396.1	dass	31..565	CDD:273267	184/538 (34%)
Slc13a3	NP_473396.1	SLC13_permease	42..556	CDD:238535	179/518 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836883
Domainoid	1	1.000	383	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG0471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1967
Isobase	1	0.950	-	0.875	Normalized mean entropy	S3349
OMA	1	1.010	-	-		QHG57284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm8724
orthoMCL	1	0.900	-	-		OOG6_101290
Panther	1	1.100	-	-	O	PTHR10283
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.750