DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Indy and slc13a5

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_004911787.1	Gene:	slc13a5 / 100490590	XenbaseID:	XB-GENE-983513	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	219/586 - (37%)
Similarity:	342/586 - (58%)	Gaps:	43/586 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CSNFFANHWKGLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFP 97
            |..:..|..:.|::|:.|||.||:.||.:..|..|.|.:::||::|.||.:||.||:::|::.||
Frog    20 CMKWLLNCKRFLILFITPLLLLPLPLLIKTKEASCAYCIILMAVYWCTEVIPLAVTALLPVLLFP 84

  Fly    98 IMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTM 162
            :.||:.|.:.|..|.|||.::|:||::||:|||:.|||||:||:|:.|||..|..|..|.:.||.
Frog    85 MFGILESKKVCMQYLKDTNMLFVGGLIVAVAVEHWNLHKRIALKVLLIVGVRPALLMLGFMGVTA 149

  Fly   163 FLSMWISNAACTAMMCPIIQAVLEELQAQG---------------------VCKINHEPQYQIVG 206
            ||||||||.|.||||.||:||||.:|...|                     ...|..||...:..
Frog   150 FLSMWISNTATTAMMVPIVQAVLSQLNTAGEDPSMLESLEGQTNPALELETKNAIPLEPVQIVSN 214

  Fly   207 GNKKNNEDEPPYP---TKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDF 268
            |:.....:|.|..   .:|:....|.:.||:|:||..|:.||..||..||.:...|.|:.:.::|
Frog   215 GHVAEIPEEAPEKDERKRISKGMMLCVCYAASIGGTATLTGTGPNLVLKGQFTQIFPNNGDILNF 279

  Fly   269 PTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMS 333
            .::..::.|:|.|...:::.:||:.|:|....|:.........:|.|  |..||.:.|:.|||:|
Frog   280 ASWFGFAFPNMAVMLCMSWFWLQFSFIGFNFKKTWGCGATTSEKERA--AYNVIREEYRKLGPIS 342

  Fly   334 IHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKD----IRNSMPTIFVVVMCFMLPANYAFLR 394
            ..|..|:.|||.:|:::|||.||..:|||.:|.:||    :.::...:||..:.|:|||:...:.
Frog   343 YAESSVLFLFILLVLLWFTRDPGFVIGWATILFNKDNIEYVTDATVAVFVAFLLFILPASRPKIS 407

  Fly   395 YCTRR----------GGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIG 449
            .|..|          .....|..:..|:|||.:..::||.:|.|||||||||:||..||::..:|
Frog   408 CCKARKSFDLEEFEQAEEKDTFFSAPLLTWKVVHKQMPWSIVLLLGGGFALAKGSDASGLSHWLG 472

  Fly   450 NALIGLKVLPN-SVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLAC 513
            ..:..|..:|. ::.:::.:::||| |..:||||.|.:.:|:||.|:.:|.::|||:::|..|:.
Frog   473 QQMAPLHTIPPWAIAIILSLMIAVF-TECASNVATATLFLPILASMTRSIGVNPLYIMIPCTLST 536

  Fly   514 SMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQ 578
            |.||.|||:|||||:|..|.::|..||...||...||.||...:...|||..:: :|::||:||.
Frog   537 SFAFMLPVATPPNAIVFSYGHLRVSDMVKTGIVMNIIGIICTTLAINTWGRPMF-SLDTFPQWAN 600

  Fly   579 I 579
            |
Frog   601 I 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	191/515 (37%)
Indy	NP_730363.2	dass	70..545	CDD:273267	190/513 (37%)
slc13a5	XP_004911787.1	ArsB_NhaD_permease	50..592	CDD:389757	202/545 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57284
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2228
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060