DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Indy and slc13a1

DIOPT Version :9

Sequence 1:	NP_730363.2	Gene:	Indy / 40049	FlyBaseID:	FBgn0036816	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_002935016.2	Gene:	slc13a1 / 100488100	XenbaseID:	XB-GENE-487899	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	617	Identity:	209/617 - (33%)
Similarity:	329/617 - (53%)	Gaps:	98/617 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCR 109
            ::.|.|||.|||.|:.:..|..|.|:|.|:||||::|||||.||:.:|.:.||:.||:.|.....
Frog    16 LIVLTPLLLLPVPLILKSKETECAYVLFVVAIFWLSEALPLSVTAFLPALMFPLFGILPSKAVAA 80

  Fly   110 LYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACT 174
            .||||..::..|.|.:|.::|..|||||:|||::.:||.:|..|..|.:....|||||:||.:..
Frog    81 TYFKDFHLLLTGVICLATSIEKWNLHKRIALRMVMLVGVNPGWLMLGFMFSAGFLSMWLSNTSTA 145

  Fly   175 AMMCPIIQAVLEELQAQGVCKINHEPQYQIV-----GG--------NKKNNEDEP---------- 216
            ||:.||::||.:::       ||.|.:...:     ||        ::||.|.:|
Frog   146 AMVMPIVEAVAQQI-------INAEAEVDAMQTGSTGGIDNEALELDEKNCESQPKSSELKPVNG 203

  Fly   217 -------PYPTKI-----------------------------------------TLCYYLG--IA 231
                   .|.|:.                                         .:|..:|  ||
Frog   204 YSNGCVTSYNTETKAAMEEYQEYQNEACSELKTELEEEQPVSSDKKRYRCKKDHMMCKAMGLCIA 268

  Fly   232 YASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMG 296
            |:|::||..||.||:|||.|...:::|:..||: ::|.|:....:|..::..:|::::|||.|.|
Frog   269 YSSTIGGLTTITGTSTNLIFAEQFQSRYPGSTD-INFGTWFILCIPIAVILMILSWIWLQWLFFG 332

  Fly   297 LWRPKSKEAQEVQR-GREGADVAK---KVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGI 357
            .      :.:|:.: |:|..|..|   |||...|:.|||:|..||..:||||.|.:::|||.||.
Frog   333 F------DFKEMFKCGKERTDREKASAKVIKDEYEKLGPLSYQEIITLILFILMALLWFTRDPGF 391

  Fly   358 FLGWADLLNS--KDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTK 420
            ..|||.|...  ....:|...:.:.::.|::|| |.::|....:.......|   |||||..|..
Frog   392 IPGWATLFPKYMGYATDSTAALLLGLLFFIIPA-YPWIRGTKDKSNSFSYVP---LITWKEFQAC 452

  Fly   421 VPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIAN 485
            :||.:..|:|||||||||.:.||:::.|.|.:..|..||...::|:..|:...:|..:||.|...
Frog   453 MPWDICILVGGGFALAEGCEVSGLSQWIANKMTPLGSLPIWSVILISSLIVTTVTEVASNPATIT 517

  Fly   486 IIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTII 550
            |.:|:||.::.||.::|||:::|..|..|.||.||||.||||:|..|.:::..||..||:|..|:
Frog   518 IFLPILAPLAEAINVNPLYILIPTTLCTSFAFLLPVSNPPNAIVFSYGHLQVMDMVKAGLGINIM 582

  Fly   551 TIITLFVFCQTWGLVVYPNLNSFPEWAQIYAA 582
            .::.:.:...||.:.:: ||:::|.||.|..|
Frog   583 GVLVVMLAISTWAVPMF-NLDTYPSWAPIITA 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Indy	NP_730363.2	SLC13_permease	68..545	CDD:238535	187/555 (34%)
Indy	NP_730363.2	dass	70..545	CDD:273267	186/553 (34%)
slc13a1	XP_002935016.2	SLC13_permease	39..591	CDD:238535	190/569 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	357	1.000	Domainoid score	I978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2088
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282824at33208
OrthoFinder	1	1.000	-	-		FOG0000298
OrthoInspector	1	1.000	-	-		mtm9386
Panther	1	1.100	-	-	O	PTHR10283
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160