DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cat and cat.2

DIOPT Version :9

Sequence 1:	NP_536731.1	Gene:	Cat / 40048	FlyBaseID:	FBgn0000261	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001072167.1	Gene:	cat.2 / 548403	XenbaseID:	XB-GENE-976955	Length:	528	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	332/506 - (65%)
Similarity:	401/506 - (79%)	Gaps:	7/506 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RDAASNQLIDYKNSQ-TVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERI 67
            ||.|::|:..:|.|: :..|..:|||.|.||..|....|||||||:|:|||.|.|||:|||||||
Frog     5 RDNAADQMKLWKESRGSQKPDVLTTGGGNPISDKLNLLTVGPRGPLLVQDVVFTDEMAHFDRERI 69

  Fly    68 PERVVHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAV 132
            |||||||||||||||||:|||||:|..||:|:.:.||||:|:|||||.||||||||.||||||||
Frog    70 PERVVHAKGAGAFGYFEITHDITKYSKAKVFEHIGKRTPIAIRFSTVAGESGSADTVRDPRGFAV 134

  Fly   133 KFYTEDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCIL 197
            |.|||||.|||.|||||||||||.:|||||||:||||||||||||||.|||..|||||.|||..|
Frog   135 KMYTEDGNWDLTGNNTPVFFIRDAMLFPSFIHSQKRNPQTHLKDPDMVWDFWALRPESLHQVSFL 199

  Fly   198 FSDRGTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRD 262
            |||||.|||:.||||||||||||:|||.|.:|.|||:||||||:||.|:.|::|:::||||.|.|
Frog   200 FSDRGIPDGHRHMNGYGSHTFKLVNAKDEAVYCKFHYKTDQGIRNLTVEEANRLSASDPDYGIHD 264

  Fly   263 LYNRIKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNPKNYFAEV 327
            ||..|....:|||:.||||||::||:|||:||||:||:|...:||||||||:||:|||.||||||
Frog   265 LYESIAAGNYPSWSFYIQVMTFQQAEKFKFNPFDLTKIWPHGDYPLIPVGKLVLNRNPTNYFAEV 329

  Fly   328 EQIAFSPAHLVPGVEPSPDKMLHGRLFSYSDTHRHRLGPNYLQIPVNCPYKVKIENFQRDGAMNV 392
            ||:||.|:::.||:||||||||.||||||.|||||||||||||:||||||:.::.|:||||.|..
Frog   330 EQLAFDPSNMPPGIEPSPDKMLQGRLFSYPDTHRHRLGPNYLQLPVNCPYRTRVANYQRDGPMCF 394

  Fly   393 TDNQDGAPNYFPNSFNGPQECPRARALSSCCPVTGDVYRYSSGDTEDNFGQVTDFWVHVLDKCAK 457
            ||||.|||||:||||..|:..|:.|  .....|:.||.||:|.| |||..||.||:|.||.:..:
Frog   395 TDNQGGAPNYYPNSFCAPENQPQVR--EHRFHVSADVARYNSAD-EDNVSQVRDFYVKVLSEEQR 456

  Fly   458 KRLVQNIAGHLSNASQFLQERAVKNFTQVHADFG---RMLTEELNLAKSSK 505
            .||.:||||||.:|..|:|:|||||||.||.::|   :.|.::.|...:.|
Frog   457 LRLCENIAGHLKDAQLFIQKRAVKNFTDVHPEYGARIQALLDKYNAEGAKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cat	NP_536731.1	KatE	10..505	CDD:223824	328/498 (66%)
Cat	NP_536731.1	catalase_clade_3	66..498	CDD:163712	296/434 (68%)
cat.2	NP_001072167.1	catalase_clade_3	68..497	CDD:163712	295/431 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	624	1.000	Domainoid score	I178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55514
Inparanoid	1	1.050	696	1.000	Inparanoid score	I665
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172396at33208
OrthoFinder	1	1.000	-	-		FOG0001359
OrthoInspector	1	1.000	-	-		mtm9352
Panther	1	1.100	-	-	LDO	PTHR11465
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R169
SonicParanoid	1	1.000	-	-		X851
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190