DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cat and ctl-3

DIOPT Version :9

Sequence 1:	NP_536731.1	Gene:	Cat / 40048	FlyBaseID:	FBgn0000261	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_741058.1	Gene:	ctl-3 / 175086	WormBaseID:	WBGene00013220	Length:	512	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	305/492 - (61%)
Similarity:	370/492 - (75%)	Gaps:	5/492 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASNQLIDYKNSQTVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERIPERV 71
            |.:||..|:: :...|..:||.|||||..|.|..|.|.|||:|:||:.::|||:|||||||||||
Worm    21 AEDQLKAYRD-RNQEPHLLTTSNGAPIYSKTAVLTAGRRGPMLMQDIVYMDEMAHFDRERIPERV 84

  Fly    72 VHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAVKFYT 136
            |||||.||.||||||||||:||.|.:|:||.|:|||.||||||.||||||||.||||||::||||
Worm    85 VHAKGGGAHGYFEVTHDITKYCKADMFNKVGKQTPLLVRFSTVAGESGSADTVRDPRGFSLKFYT 149

  Fly   137 EDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCILFSDR 201
            |:|.|||||||||:|||||.|.||:|||..|||||||::||:..:||...||||.|||..|:|||
Worm   150 EEGNWDLVGNNTPIFFIRDAIHFPNFIHALKRNPQTHMRDPNALFDFWMNRPESIHQVMFLYSDR 214

  Fly   202 GTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRDLYNR 266
            |.|||:..|||||:||||::|.:|.|||.|||||..||.||||...|.:|||:||||:||||:|.
Worm   215 GIPDGFRFMNGYGAHTFKMVNKEGNPIYCKFHFKPAQGSKNLDPTDAGKLASSDPDYAIRDLFNA 279

  Fly   267 IKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNPKNYFAEVEQIA 331
            |::..||.|.|:|||||:|||:|:::|||||||||...:||||.||||||:||.|||||||||.|
Worm   280 IESRNFPEWKMFIQVMTFEQAEKWEFNPFDVTKVWPHGDYPLIEVGKMVLNRNVKNYFAEVEQAA 344

  Fly   332 FSPAHLVPGVEPSPDKMLHGRLFSYSDTHRHRLGPNYLQIPVNCPYKVKIENFQRDGAMNVTDNQ 396
            |.|||:|||:|.||||||.||:|||:|||.|||||||:|:||||||:.:....|||||| ..::|
Worm   345 FCPAHIVPGIEFSPDKMLQGRIFSYTDTHYHRLGPNYIQLPVNCPYRSRAHTTQRDGAM-AYESQ 408

  Fly   397 DGAPNYFPNSFNGPQECPRARALSSCCPVTGDVYRYSSGDTEDNFGQVTDFWVHVLDKCAKKRLV 461
            ..|||||||||.|.:  .|.....|....||||.||.:|| :.|:.|...||..||.:..:.|||
Worm   409 GDAPNYFPNSFRGYR--TRDDVKESTFQTTGDVDRYETGD-DHNYEQPRQFWEKVLKEEERDRLV 470

  Fly   462 QNIAGHLSNASQFLQERAVKNFTQVHADFGRMLTEEL 498
            .|:|..|....:.:|...||.||:||.|||..|..:|
Worm   471 GNLASDLGGCLEEIQNGMVKEFTKVHPDFGNALRHQL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cat	NP_536731.1	KatE	10..505	CDD:223824	304/489 (62%)
Cat	NP_536731.1	catalase_clade_3	66..498	CDD:163712	274/431 (64%)
ctl-3	NP_741058.1	KatE	38..507	CDD:223824	299/472 (63%)
ctl-3	NP_741058.1	catalase_clade_3	79..507	CDD:163712	274/431 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167839
Domainoid	1	1.000	601	1.000	Domainoid score	I95
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55514
Inparanoid	1	1.050	665	1.000	Inparanoid score	I391
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62736
OrthoDB	1	1.010	-	-		D172396at33208
OrthoFinder	1	1.000	-	-		FOG0001359
OrthoInspector	1	1.000	-	-		mtm4808
orthoMCL	1	0.900	-	-		OOG6_100495
Panther	1	1.100	-	-	LDO	PTHR11465
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X851
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870