DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cat and ctl-2

DIOPT Version :9

Sequence 1:	NP_536731.1	Gene:	Cat / 40048	FlyBaseID:	FBgn0000261	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001022473.1	Gene:	ctl-2 / 175085	WormBaseID:	WBGene00000831	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	322/487 - (66%)
Similarity:	382/487 - (78%)	Gaps:	5/487 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DAASNQLIDYKNSQTVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERIPE 69
            |.:.|||..||.:.. .|..|||.|||||..|.|..|.|.|||:|:|||.::|||:|||||||||
Worm     4 DPSDNQLKTYKETYP-KPQVITTSNGAPIYSKTAVLTAGRRGPMLMQDVVYMDEMAHFDRERIPE 67

  Fly    70 RVVHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAVKF 134
            ||||||||||.|||||||||::||.|.||:||.|:|||.:||||||||||||||||||||||:||
Worm    68 RVVHAKGAGAHGYFEVTHDISKYCKADIFNKVGKQTPLLIRFSTVGGESGSADTARDPRGFAIKF 132

  Fly   135 YTEDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCILFS 199
            |||:|.|||||||||:|||||||.||:||||||||||||||||:|.:||...|||:.|||..|||
Worm   133 YTEEGNWDLVGNNTPIFFIRDPIHFPNFIHTQKRNPQTHLKDPNMIFDFWLHRPEALHQVMFLFS 197

  Fly   200 DRGTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRDLY 264
            |||.||||.|||||||||||::|..|:.||.|||||..||:|||.|:.|.||||:|||||||||:
Worm   198 DRGLPDGYRHMNGYGSHTFKMVNKDGKAIYVKFHFKPTQGVKNLTVEKAGQLASSDPDYSIRDLF 262

  Fly   265 NRIKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNPKNYFAEVEQ 329
            |.|:...||.|.|:|||||:|||:|:::|||||||||...:||||.||||||:|||:||||||||
Worm   263 NAIEKGDFPVWKMFIQVMTFEQAEKWEFNPFDVTKVWPHGDYPLIEVGKMVLNRNPRNYFAEVEQ 327

  Fly   330 IAFSPAHLVPGVEPSPDKMLHGRLFSYSDTHRHRLGPNYLQIPVNCPYKVKIENFQRDGAMNVTD 394
            .||.|||:|||:|.||||||.||:|||:|||.|||||||:|:||||||:.:..|.|||||| ..|
Worm   328 SAFCPAHIVPGIEFSPDKMLQGRIFSYTDTHFHRLGPNYIQLPVNCPYRSRAHNTQRDGAM-AYD 391

  Fly   395 NQDGAPNYFPNSFNGPQECPRARALSSCCPVTGDVYRYSSGDTEDNFGQVTDFWVHVLDKCAKKR 459
            ||..|||:||||||..:..|..:  .:..|.||||.||.||| ::|:.|...||..|||..|::|
Worm   392 NQQHAPNFFPNSFNYGKTRPDVK--DTTFPATGDVDRYESGD-DNNYDQPRQFWEKVLDTGARER 453

  Fly   460 LVQNIAGHLSNASQFLQERAVKNFTQVHADFG 491
            :.||.||.|.....|:.:..:.:|::||.|||
Worm   454 MCQNFAGPLGECHDFIIKGMIDHFSKVHPDFG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cat	NP_536731.1	KatE	10..505	CDD:223824	320/482 (66%)
Cat	NP_536731.1	catalase_clade_3	66..498	CDD:163712	288/426 (68%)
ctl-2	NP_001022473.1	catalase_clade_3	64..492	CDD:163712	288/426 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167837
Domainoid	1	1.000	601	1.000	Domainoid score	I95
eggNOG	1	0.900	-	-		E1_COG0753
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55514
Inparanoid	1	1.050	665	1.000	Inparanoid score	I391
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62736
OrthoDB	1	1.010	-	-		D172396at33208
OrthoFinder	1	1.000	-	-		FOG0001359
OrthoInspector	1	1.000	-	-		mtm4808
orthoMCL	1	0.900	-	-		OOG6_100495
Panther	1	1.100	-	-	O	PTHR11465
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R169
SonicParanoid	1	1.000	-	-		X851
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840