DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14073 and BCORL1

DIOPT Version :9

Sequence 1:NP_001262022.1 Gene:CG14073 / 40046 FlyBaseID:FBgn0036814 Length:2133 Species:Drosophila melanogaster
Sequence 2:NP_001171701.1 Gene:BCORL1 / 63035 HGNCID:25657 Length:1785 Species:Homo sapiens


Alignment Length:2280 Identity:470/2280 - (20%)
Similarity:725/2280 - (31%) Gaps:859/2280 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 SAQGSGAAGTSGSDPHMQYYTSNQNLAIK---KMSDPHPMWSY-----KSQAVTTP--APAPGLR 192
            :|.||| :...|:||.   .::.:.|..|   |..||.|...|     :::.:..|  :|..||:
Human    63 TAVGSG-SNARGADPD---GSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLK 123

  Fly   193 QHGNPALYPTGSTA--YWPPPDEQLHHQ------------------QPSRYSYAKPGGPVTGSRP 237
            ...:.:...:.|.|  .|.|.:.|:..|                  :.:.:..|..|..|    |
Human   124 LPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVKALDSRQGVGEKNTFILATLGTGV----P 184

  Fly   238 IQGPLPNSQRYYSEDIKYSTVPAASKVLTYAPPA--SSSQPQPPP-----PTSSSSANSSSVRHY 295
            ::|.||      .....:|.:||     ...|||  |:|.|...|     |.|.    .:.|.|.
Human   185 VEGTLP------LVTTNFSPLPA-----PICPPAPGSASVPHSVPDAFQVPLSV----PAPVPHS 234

  Fly   296 ELDVVNPSNPSNEHQQPSPNYGRKCPPHYETPPEQRSAGATPN--STGTPTSTSHHQSLYIPMPT 358
            .|..|..:.     ..|:|:     ||....|....:..:.|.  |...|.|.|  .|:.:|:|.
Human   235 GLVPVQVAT-----SVPAPS-----PPLAPVPALAPAPPSVPTLISDSNPLSVS--ASVLVPVPA 287

  Fly   359 FSTEKFQTTVHNAIEKYIRETPGPSLEYPRGGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYV 423
                                :..||...|....||                ||.|||.:|     
Human   288 --------------------SAPPSGPVPLSAPAP----------------APLSVPVSA----- 311

  Fly   424 KMEPEHALAGGLPQPTRSSLYHNPYNVESRERDSSPAMATVPAPHGYPTKYGKLIQQQHAASGVG 488
               |..||......|:..:|...|.        .:|.:|.:||                     .
Human   312 ---PPLALIQAPVPPSAPTLVLAPV--------PTPVLAPMPA---------------------S 344

  Fly   489 TGSSAPYQSYYHQGTPSPAAGAVASPT------PAPLPPLAEAPGTIFGPGTGLNPGIPPHSSQP 547
            |..:||........||:|::|..::||      |.|:|  |..|..||.|.             |
Human   345 TPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVP--APTPAPIFTPA-------------P 394

  Fly   548 VPPPANSQQPASSSSSSNANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNY 612
            .|.||.:.....:|:...|:||..:|       |:                 ||.::||:.|   
Human   395 TPMPAATPAAIPTSAPIPASFSLSRV-------CF-----------------PAAQAPAMQK--- 432

  Fly   613 RALINDMLKRNTASEQELNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPAAISIPSAPPP--PP 675
                                                       :..|..|..:..||.|..  ||
Human   433 -------------------------------------------VPLSFQPGTVLTPSQPLVYIPP 454

  Fly   676 PAIHSPLDLSMRTVKQTADST-------------------------EYKY----QRPST-DYKLP 710
            |:...||.::.........||                         .|.|    .||.| |.||.
Human   455 PSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLV 519

  Fly   711 QGGLGGGLGLPRFDIT-PNFSAATR---GGAPTSPAPTPVIRQAVAIQPAPVPPTVPVPPAVAAP 771
                  .|.:.|...| |:.|..|:   .|.|...|.|.::..:..:.|.| .|.:|.|...:||
Human   520 ------SLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTP-QPLLPAPSGSSAP 577

  Fly   772 ALVIK----TVQQMRPSVVETNPF-----AKRQQQLPPETSIVQV---TKPTVELMPTPS----- 819
            ....|    |.||...:.|..:|.     .:|:...|||.|.:.:   :|...:.:|.|:     
Human   578 PHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTP 642

  Fly   820 PSP-----HNSSNPNYLGKKRHLQEYNQAAAKQAR--LDAESSGSLV----------------SG 861
            |.|     |.||...........|...|||.....  |.:.||..::                |.
Human   643 PMPVLTPVHTSSKALLSTVLSRSQRTTQAAGGNVTSCLGSTSSPFVIFPEIVRNGDPSTWVKNST 707

  Fly   862 APVIAAPTSVVVVA-PVPV-IAVNEQA-LAAKREREMQSMSAESSTSAHLVPKMEP-RIRTKAEL 922
            |.:...|.:.|.|| |||. :.:|:.. |...|:            ..|| ||.|| .|..:.|.
Human   708 ALISTIPGTYVGVANPVPASLLLNKDPNLGLNRD------------PRHL-PKQEPISIIDQGEP 759

  Fly   923 KGFTFTPPVLVTSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATDLGLDDEQHSLGNLMDWG 987
            ||        ..:|.....:.:.....|:.:..:...::.|..|     |...::.||     | 
Human   760 KG--------TGATCGKKGSQAGAEGQPSTVKRYTPARIAPGLP-----GCQTKELSL-----W- 805

  Fly   988 STCNNLVEQLMSKVVVPPTLPAN-NPGIKLE---LSEDDLPVARILKRQPLAAPSLAGGDAESAT 1048
                            .||.||| .|...:.   .|...|||.    ..|....||......|| 
Human   806 ----------------KPTGPANIYPRCSVNGKPTSTQVLPVG----WSPYHQASLLSIGISSA- 849

  Fly  1049 TQLTTTTNG---ISSSLGNGSGQKKLSKVEREKKRQQQEQRIAARLAPKQGQSSSSESDTTELHK 1110
            .|||.:...   .:|.:...||...||..|......:.:.|......|:  |...:::.|..:..
Human   850 GQLTPSQGAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPE--QDPVTKNKTCRIAA 912

  Fly  1111 RNTARQKKPLLRKGRTRQRSPE----AASIQQSSDEEQEKVSQRLSRKPRTSSEESKTKATSAKK 1171
            :....|..|:|     ...||:    |.|:|.|..:      .|:::.|    |||::...|   
Human   913 KPYEEQVNPVL-----LTLSPQTGTLALSVQPSGGD------IRMNQGP----EESESHLCS--- 959

  Fly  1172 DVKKEAKTP----------SNKTNNSASLTKIKKKTTDSSSLNKAK--------GDENPKQ---- 1214
            |...:.:.|          ..|..|....|.:..:...::..|..|        .|.:||:    
Human   960 DSTPKMEGPQGACGLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKELILD 1024

  Fly  1215 ---ESQESTSSESDQ------------DDNDND-------------------NDEEEEDQEEDEE 1245
               .|:..:|:|..|            :..|.|                   ..:.|...:..:.
Human  1025 VVPSSRRGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQAEVRAKAGQA 1089

  Fly  1246 EPEEE-------------DDDEEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSKHRKELELQLA 1297
            ..::|             ||..|....|:.:.|:.. ::.::::..:...:.||.||.:      
Human  1090 RVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEK-DSEEQQLQPQAKAVVRSSHRPK------ 1147

  Fly  1298 NSKVLRNDKIIRNSTTKIKRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRNSKLKGSK-VG 1361
             .:.|.:|.  :.||    :|..|...||.||.               ..:.|::...|.:| ..
Human  1148 -CRKLPSDP--QEST----KKSPRGASDSGKEH---------------NGVRGKHKHRKPTKPES 1190

  Fly  1362 NSPGKPKTSPQQQLYLEEYRYKLALKIPHSLISINKLNKVASSLPDLERRDLSQELACFKRNRPK 1426
            .||||...|.::                      ..|.|.|.|                      
Human  1191 QSPGKRADSHEE----------------------GSLEKKAKS---------------------- 1211

  Fly  1427 TKAASKQDFTPKSIIDVLHLRVTNGSTAGTQRKISVSAPASTNL---QIHSETSQTSASTSLYEQ 1488
                |.:||.|  ::.....|..:||...:...::.|...|..:   :...|.:.|.|......:
Human  1212 ----SFRDFIP--VVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTPTPAKRRKVRK 1270

  Fly  1489 SQQD-----NPTENQSLDDMSKRHF--------------SIFDTK----------VLQSKTRTET 1524
            :|:|     :..:::||....:||.              .::||.          :|:.|.|...
Human  1271 TQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEEEEEEGLLKRKKRRRQ 1335

  Fly  1525 KLQKHR--EIIREIFVGPERPASAPPECVQEADGGDAISYQKYEEFLQQMNSIASANDSKLARRS 1587
            |.:|::  |.:.|            .|..|...|...:..:|      |..|.:.:.:.:|..|:
Human  1336 KSRKYQTGEYLTE------------QEDEQRRKGRADLKARK------QKTSSSQSLEHRLRNRN 1382

  Fly  1588 LMEDKSVTA---------------PQC-------PHKRKYRCR-----------KGSSGFDYIRK 1619
            |:....|..               |.|       ..|||.:.:           ||.......|.
Human  1383 LLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKGKGRWSQQKTRS 1447

  Fly  1620 KKRPAPTQ-TQNHTQNQSQSQVSSQITQHILEHNQSAADERLEDTDSTIAGSSHLPPKVKTEMDV 1683
            .|.|.|.: |:..|.::|                :||:.|...::.:    :..:||        
Human  1448 PKSPTPVKPTEPCTPSKS----------------RSASSEEASESPT----ARQIPP-------- 1484

  Fly  1684 CREIQKWVLNKGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWLEIAR 1748
              |.::.::||..|::.:.:|||.|..|||:|||.:.:.:.:.:||||||.|||||::||.:|..
Human  1485 --EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILN 1547

  Fly  1749 ILLQYGANHSEAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLMRGIL 1813
            |||::|||.:.:||.|.||:|.|:.||:.|.:.|||||||||.||||||||.:.||||..|:..|
Human  1548 ILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFL 1612

  Fly  1814 RAHLSDAQSAAADIKPMRFNGP---WEIFDAKEYGYDIFSNVPNTACDMSRALRKERKEAKQQRM 1875
            ..||||.|..|.       ..|   |:.     |...:.......|||:.               
Human  1613 SDHLSDLQGRAE-------GDPGVSWDF-----YSSSVLEEKDGFACDLL--------------- 1650

  Fly  1876 SSNSDRTSNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTTTATTMVKLELGTD 1940
                               ...|...||:.                                   
Human  1651 -------------------HNPPGSSDQEG----------------------------------- 1661

  Fly  1941 EDSNNNKNNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKANTNSSTRLDEDQTD 2005
                                                                             
Human  1662 ----------------------------------------------------------------- 1661

  Fly  2006 IETMDSELNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVKSKDTLLNKLCPNN 2067
                |..:..|.|.||.:|.||.|.|.|:   ..|...|.|.:|:...||:.|:  :.....|: 
Human  1662 ----DDPMEEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSR--IFQARFPH- 1719

  Fly  2068 SNALASSQKHLLREFKID-----DFLEKATCLQLLCAGEKLNMF-------SSSKVVLIKYNDSV 2120
                          |:|.     :|..:....|||...|:....       ||..|.|::|...:
Human  1720 --------------FEITTMPKAEFYRQVASSQLLTPAERPGGLDDRSPPGSSETVELVRYEPDL 1770

  Fly  2121 RNLLG 2125
            ..|||
Human  1771 LRLLG 1775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14073NP_001262022.1 ANK 1697..1807 CDD:238125 61/109 (56%)
ANK repeat 1697..1728 CDD:293786 11/30 (37%)
Ank_2 1702..1790 CDD:289560 47/87 (54%)
ANK repeat 1730..1761 CDD:293786 18/30 (60%)
ANK repeat 1763..1788 CDD:293786 13/24 (54%)
PUFD_like 2016..2129 CDD:271222 33/125 (26%)
BCORL1NP_001171701.1 PHA03247 <198..636 CDD:223021 131/623 (21%)
ANK repeat 1496..1527 CDD:293786 11/30 (37%)
Ank_2 1500..1591 CDD:403870 49/90 (54%)
ANK repeat 1529..1560 CDD:293786 18/30 (60%)
ANK repeat 1562..1591 CDD:293786 17/28 (61%)
PUFD_like_1 1666..1779 CDD:271223 33/127 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159228
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2AIVP
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 231 1.000 Inparanoid score I3441
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0008249
OrthoInspector 1 1.000 - - otm40374
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24117
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9799
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.920

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