DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14073 and BCOR

DIOPT Version :9

Sequence 1:NP_001262022.1 Gene:CG14073 / 40046 FlyBaseID:FBgn0036814 Length:2133 Species:Drosophila melanogaster
Sequence 2:NP_001116857.1 Gene:BCOR / 54880 HGNCID:20893 Length:1755 Species:Homo sapiens


Alignment Length:2263 Identity:443/2263 - (19%)
Similarity:718/2263 - (31%) Gaps:847/2263 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 SAIYMSRS--TQPGLPPPH--PHSSAQGSG-------AAGTSGS-------DPHMQYYTSNQNLA 164
            :|:.|.|:  .:.||..|.  .:||..|.|       |..|.|.       :|.||:        
Human    68 AALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQF-------- 124

  Fly   165 IKKMSDPHPMWSYKSQAVTTPAPAPGLRQHGNPALYPTGSTAYWPPPD---------EQLHHQQP 220
                 .|:...:.::.||:...|      :|..|:|.|       ||.         |.|...:|
Human   125 -----KPNTPETVEASAVSGKPP------NGFSAIYKT-------PPGIQKSAVATAEALGLDRP 171

  Fly   221 S---------------RYSYAKPGGPVTGSRPIQGPLPNSQRYYSEDIKYSTVPAASKVLT---Y 267
            :               |..:..|  .:.|:.|...|..:|...||.::..:.:|..|..|.   |
Human   172 ASDKQSPLNINGASYLRLPWVNP--YMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLY 234

  Fly   268 APPASSSQP---QPPP-------PTSSSSANSSSVRHYELDV----------------VNPSNPS 306
            :|..::.:.   .|||       |:|.:|....|.......:                |:|.||.
Human   235 SPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPV 299

  Fly   307 NEHQQPSPNYGRKCPPHYETPPEQRSAGATPNSTGTPTST------SHHQSLYIPMPTFSTEKFQ 365
            :.|..          ||.:...:.|...|...::|.|..|      |...|..:.:||.......
Human   300 DSHAY----------PHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTY 354

  Fly   366 TTVHNAIEKYIRETPGPSL---------------------EYPRG-----GVAPV-GRTGYYNQQ 403
            :..|   :.|.|.:..||:                     :||:.     |..|| |.......|
Human   355 SEFH---KHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQ 416

  Fly   404 PMKSSKAPPSV-PQTAT----------SSYV------------KMEPE---HALAGG-------- 434
            ..|...:||.: .||.|          ||.|            ||.|.   |:.||.        
Human   417 DRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSE 481

  Fly   435 LPQPTRSSLYHNPYNVESRERDSSPAMATVPAPHGYPTKYGK-----------LIQQQHAAS--G 486
            :|:.|.|...:......|....::|:...||.|.......||           .|.||.::|  .
Human   482 IPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPR 546

  Fly   487 VGTGSSAPYQSYYHQGTPSPAAGAVASPTPAPLPPLAEAPGT-IFGPGTGLNPGIPPHSSQPVPP 550
            :| |:.|...:.  .|:.| :||..||.:||   |.|.|.|| .........|.:..|..|   |
Human   547 MG-GTDAVITNV--SGSVS-SAGRPASASPA---PNANADGTKTSRSSVETTPSVIQHVGQ---P 601

  Fly   551 PANSQQPASSSSSSNANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNYRAL 615
            ||...:.:||:||..|..|                             ||        :|:::|.
Human   602 PATPAKHSSSTSSKGAKAS-----------------------------NP--------EPSFKAN 629

  Fly   616 INDMLKRNTASEQELNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPAAISIPSAPPPPPPAIHS 680
            .|.:                       |.|| ...:|:...:            :||.|.|..:.
Human   630 ENGL-----------------------PPSS-IFLSPNEAFR------------SPPIPYPRSYL 658

  Fly   681 PLDLSMRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPNFSAATRGGAPTSPAPTP 745
            |                         |..|:|          ..::|   .:..|..|.  .|.|
Human   659 P-------------------------YPAPEG----------IAVSP---LSLHGKGPV--YPHP 683

  Fly   746 VIRQAVAIQPAPVPPTVPVPPAVAAPALVIKTVQ------QMRPSVVETNPFAKRQQQLPPETS- 803
            |:....::.|..:.|...:|..:........|.|      .:.|.::...|....:::.|...| 
Human   684 VLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSR 748

  Fly   804 ---IVQVTKPTV-----ELMPTPS-------PSPHN-SSNPNYLGKKRHLQEYNQAAAKQARLDA 852
               ..:...||:     |::.|.|       |:..| ..|||          :||          
Human   749 SHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPN----------WNQ---------- 793

  Fly   853 ESSGSLVSGAPVIAAPTSVVVVAPVPVIAVNEQALAAKREREMQSMSAESSTSAHLVPKMEPRIR 917
                    |..|:.:...|.|              ...||                    ||..:
Human   794 --------GKTVVKSDKLVYV--------------DLLRE--------------------EPDAK 816

  Fly   918 TKAELKGFTFTPPVLVTSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATD-LGLDDEQHSLG 981
            |...           |:..:.|:.::.....||..       .:|||..:..| :.|.:|   ||
Human   817 TDTN-----------VSKPSFAAESVGQSAEPPKP-------SVEPALQQHRDFIALREE---LG 860

  Fly   982 NLMDWGS--TCNNLVEQLMSKVVVPPT------LPANNPGIKLELSEDDLPVARILKRQPLAAPS 1038
            .:.|:..  |....|..:....|:..|      ||.:.|.::..|..|. |.....|.|....|.
Human   861 RISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDG-PAVTFGKTQEDPKPF 924

  Fly  1039 LAGGDAESATTQLTTTTNGISSSLGNGSGQKKLSKVEREKKRQQQEQRIAARLAPKQGQ-SSSSE 1102
            ..|....|.....|.|.:|...:..|.      .||.:.|     ..::|.|:|...|. ....:
Human   925 CVGSAPPSVDVTPTYTKDGADEAESND------GKVLKPK-----PSKLAKRIANSAGYVGDRFK 978

  Fly  1103 SDTTELHKRNTARQKKPLLRKGRTRQRSPEAASIQQSSDEEQ----------EKVSQRLSRKPRT 1157
            ..||||:..::              |.|.|..::|....:|.          |:...|.|     
Human   979 CVTTELYADSS--------------QLSREQRALQMEGLQEDSILCLPAAYCERAMMRFS----- 1024

  Fly  1158 SSEESKTKATSAKKDVKKEAKTPSNKTNNSASLTKIKKKTTDSSSLNKAKGDENPKQESQESTSS 1222
               |.:.|        ::|...|:.|.:.....:        .:...:.||:::.|.:|.....:
Human  1025 ---ELEMK--------EREGGHPATKDSEMCKFS--------PADWERLKGNQDKKPKSVTLEEA 1070

  Fly  1223 ESDQDDNDNDNDEEEEDQEEDEEEPEEEDDDEEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSK 1287
            .::|::::...........:..|.||::|...|:...:.:.|...|.:.:...:.|         
Human  1071 IAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPH--------- 1126

  Fly  1288 HRKELELQLANSKVLRNDKIIRNSTTKIKRK------YVRKVVDSKKEMMVTRLRNKRGMNSDLG 1346
                       |..||.|:         |||      :.....:...|..:.:.:.:|....|. 
Human  1127 -----------SPTLRVDR---------KRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDW- 1170

  Fly  1347 ALNGRNSKLKGSKVGNSPGKPKTSPQQQLYLEEYRYKLALKIPHSLISINKLNKVASSLPDLERR 1411
                                    |::::                      .|..::.|.|....
Human  1171 ------------------------PEREM----------------------TNSSSNHLEDPHYS 1189

  Fly  1412 DLSQELACFKRNRPKTKAASKQDFTPKSIIDVLHLR--------VTNGSTAGTQRKISVSA---- 1464
            :|:....|.:..          ...||....:||||        ..:|......||....|    
Human  1190 ELTNLKVCIELT----------GLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPE 1244

  Fly  1465 --PASTNLQIHS---ETSQTSASTSLYEQSQQDNPTENQSLDDMSKRHFSIFD-TKVLQSKTRTE 1523
              |..||:....   :.::...:.|..|:|.:  |::|:       :...:|. :..::|.:.|.
Human  1245 AIPQGTNITEEKPGRKRAEAKGNRSWSEESLK--PSDNE-------QGLPVFSGSPPMKSLSSTS 1300

  Fly  1524 TKLQKHREIIREIFVGPE-RPASAPPE--------------CVQEADGGDAIS-YQKYEEFLQQM 1572
            ...:|..:        |. .|||.||.              |..|.:...|.| .|||.:     
Human  1301 AGGKKQAQ--------PSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTD----- 1352

  Fly  1573 NSIASANDSKLARRSLMEDKSVTAPQ-----CPHKRKYRCRKGSSGFDYIRKKKRPAPTQTQNHT 1632
                  |..|.:.:.|.:.|.: .||     .|...:|............|.:|||.|:...:.:
Human  1353 ------NSEKPSGKRLCKTKHL-IPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLS 1410

  Fly  1633 QNQSQSQVSSQITQHILEHNQS----AADERLEDTDSTIAGSSHLPPKVKTEMDVCREIQKWVLN 1693
            ..:.:.:...:: |.:|..:||    .:....|.|.     |..:||          |.::.::|
Human  1411 PAKQEPKPFDRL-QQLLPASQSTQLPCSSSPQETTQ-----SRPMPP----------EARRLIVN 1459

  Fly  1694 KGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWLEIARILLQYGANHS 1758
            |..|::.:.:|||.|..:||:|||:....:.:.:|||||..|||||.:|||.|.|.||:|||:.:
Human  1460 KNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVN 1524

  Fly  1759 EAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLMRGILRAHLSDAQSA 1823
            .:||.|.||||.|:||||.|:|||||||||||.||||||:|.:.:..|:||...|..:|:|.|..
Human  1525 CSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGR 1589

  Fly  1824 AADIKPMRFNGPWEIFDAK------EYGYDIFSNVPNTACDMSRALRKERKEAKQQRMSSNSDRT 1882
            ..|    ..:|.|:.:.:.      |.|||:.:|.|.                            
Human  1590 NDD----DASGTWDFYGSSVCEPDDESGYDVLANPPG---------------------------- 1622

  Fly  1883 SNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTTTATTMVKLELGTDEDSNNNK 1947
                           |||.|.                                            
Human  1623 ---------------PEDQDD-------------------------------------------- 1628

  Fly  1948 NNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKANTNSSTRLDEDQTDIETMDSE 2012
                                                                          |.:
Human  1629 --------------------------------------------------------------DDD 1631

  Fly  2013 LNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVKSKDTLLNKLCPNNSNALASS 2074
            ...|:||||.::.||.|.|.::   .:|...|:||:|:...||:.|:....|  .||        
Human  1632 AYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCN--FPN-------- 1686

  Fly  2075 QKHLLREFKIDDFLEKATCLQLLCAG--EKLNMFSSSKVVLIKYNDSVRNLLG 2125
             ..::...:.:.:.:.:..|...|:.  |..|..|...:.|:::.:.::.|||
Human  1687 -VEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLG 1738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14073NP_001262022.1 ANK 1697..1807 CDD:238125 61/109 (56%)
ANK repeat 1697..1728 CDD:293786 10/30 (33%)
Ank_2 1702..1790 CDD:289560 51/87 (59%)
ANK repeat 1730..1761 CDD:293786 18/30 (60%)
ANK repeat 1763..1788 CDD:293786 18/24 (75%)
PUFD_like 2016..2129 CDD:271222 29/115 (25%)
BCORNP_001116857.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..345 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..438 13/49 (27%)
Interaction with BCL6 498..514 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..641 33/153 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 737..760 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 773..794 7/48 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..844 5/46 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1071..1187 23/191 (12%)
BCOR 1202..1414 CDD:292436 48/240 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1328 22/124 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1430..1451 5/25 (20%)
ANK 1457..1565 CDD:238125 62/107 (58%)
ANK 1 1462..1495 10/32 (31%)
ANK repeat 1463..1494 CDD:293786 10/30 (33%)
Ank_2 1467..1558 CDD:289560 53/90 (59%)
ANK repeat 1496..1527 CDD:293786 18/30 (60%)
ANK 2 1496..1525 18/28 (64%)
ANK repeat 1529..1558 CDD:293786 22/28 (79%)
ANK 3 1529..1558 22/28 (79%)
PUFD 1632..1746 CDD:271224 29/118 (25%)
Necessary and sufficient for interaction with PCGF1 1634..1748 29/116 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159227
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2AIVP
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40374
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24117
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9799
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.870

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