Protein Alignment CG14073 and bcor

DIOPT Version :10

• Sequence 1: NP_649060.1
• Gene: CG14073 / 40046
• FlyBaseID: FBgn0036814
• Length: 2133
• Species: Drosophila melanogaster
• Sequence 2: XP_005174000.1
• Gene: bcor / 402921
• ZFINID: ZDB-GENE-040408-1
• Length: 1796
• Species: Danio rerio
• Alignment Length: 2223
• Identity: 463/2223 - (20%)
• Similarity: 716/2223 - (32%)
• Gaps: 718/2223 - (32%)

  Fly   104 HHPTSLAEDQRGSRSAIYMSRSTQPGLPPPHPHSSAQGSGAAGTSGSD---------PHMQYYTS 159
            :.|....:.::.:.|.:.:.:|:.||:..|   ....|:| |.|.|.|         |.:.....
Zfish    59 YKPDVSLDSRKTANSFVGLYKSSPPGIQKP---LIVPGAG-ADTLGLDRRVVPGDKPPELSLNGG 119

  Fly   160 NQNLAIKKMSDPHPMWSYKSQAVTTPAPAPGLRQHGNPALYP-TGSTAY------------WPPP 211
            :..|.:       |.|               :..:....:|| ..|:.|            .|||
Zfish   120 SSYLRV-------PSW---------------MSPYHETGMYPFLDSSKYAALNMYKASILSQPPP 162

  Fly   212 DEQLHHQQPSRYSY----AKPGGPVTGSRPIQGPLPNSQRYYSEDIKYSTVPAASKVLTYAPPAS 272
                  ..|...:|    |..||.|.|:..:         :|        :|      || |||.
Zfish   163 ------YLPQHLAYQSLCAGAGGSVAGTERL---------FY--------MP------TY-PPAP 197

  Fly   273 SSQPQPP----PPTSSSSANSSSVRHYELDVVNPSNPSNEHQQPSPNYGRK-----CPPHYETPP 328
            .|.|..|    ||.:.:....|.:.|::...|....| ..|.:||. :|::     ..||:::|.
Zfish   198 ISSPLAPPLRIPPATVAPTTLSPMMHHQDKTVQSIGP-RIHHEPSA-FGQQTIHQHTQPHHQSPI 260

  Fly   329 EQR---SAGATPNSTGTPTSTSHHQSLYIPMPTFSTEKFQTTVHNAIEKYIRETPGPSL--EYPR 388
            :::   |..::.||....||:|.:.|     .|.|.......:.:.....:.....|||  :.||
Zfish   261 DRQHSSSGNSSSNSKSIRTSSSKNLS-----STSSIVSSSAGISSCTSSIVSVDSCPSLVMQPPR 320

  Fly   389 GGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYVKMEPEHALAGGLPQPTRSSLYHNPYNVESR 453
                |..|       |.:...|||.....:|..:.|                 .||.:|    |.
Zfish   321 ----PTPR-------PPQPPAAPPPPLMDSTMEFQK-----------------PLYRSP----SS 353

  Fly   454 ERDSSPAMATVPAPHGYPTKYGKLIQQ------------------QHAASGVGT---GSSAPYQS 497
            ...|||:::       :|.......|:                  ..:..|:|.   |||:|.::
Zfish   354 SSSSSPSVS-------HPVYISSASQELRSPIRSSGQKPKAKEATMESTRGMGNERKGSSSPVKT 411

  Fly   498 YYHQGTPSPAAGAVA-SPTPAPL---PPLAEAPGTIFGPGTGLNP----GIPPHSSQPVPPPANS 554
               ....||..|.:. .|...||   ..:.|..|...|..:.|..    |..|.:...:||....
Zfish   412 ---SSDKSPQQGPITKDPADKPLDLSAKIMEFEGHTNGYPSKLEALAKLGYSPAARYGLPPNREL 473

  Fly   555 QQPASSSSSSNANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNYRALINDM 619
            .:...|.|||..:.|..   |..|:|.....|.....:.||...:.|.::...:....:.|.|.:
Zfish   474 LKETLSPSSSAVSTSKT---PERPEIISTLPSSWVVPSPTQTISSEASQNKGSSIIKNKNLENVV 535

  Fly   620 LKRNTASEQELNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPA-----AISIPSAPPPPPPAIH 679
            .:..::|..:::.|......:..|....:.|.||.|   |.:|.     |.|:|:.|...|...|
Zfish   536 PQSRSSSCPKVDDQNNGSVSSSAPIIITSTSRPSSV---SPSPKMNGDWAKSVPTPPEKTPINNH 597

  Fly   680 SPLDLSMRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPNFSAATRGGAPTSPA-- 742
            |....|.....:||..||    .|...:|..|..|..|       .||:.....:|....||.
Zfish   598 SGSHSSATKPSKTAKKTE----TPDIGFKPQQSHLENG-------HTPSHLYMQQGETYLSPGLA 651

  Fly   743 --------PTPVIRQAVAIQPAPVPPTVPVPPAVAAPALVIKTVQQMRPSVVETNPFAKRQQQLP 799
                    |.|.......:|.:...|..|.|..:.|.:| ..|....:|.:    ||.     :|
Zfish   652 YSSRYLSYPVPESLSLSHLQLSGKGPVYPHPVLLGANSL-YSTRLPPKPGI----PFG-----IP 706

  Fly   800 PETSIVQVTKPTVELMPTPSPSPH----------NSSNPNYLGKKRHLQE--YNQAAAKQARLDA 852
            |..: ..:|....:.|..|..|||          ....|..|.|..|..|  |.:.:......|.
Zfish   707 PNHA-EYLTYHDSQEMVHPLMSPHLPLDHKVTERLDLRPRTLDKTWHHDEPPYKRQSITDIDPDY 770

  Fly   853 ESSGSLVSGAPVIAAPTSVVVVAPVPVIAVNEQALAAKREREMQSMSAESSTSAHLVPKMEPRIR 917
            :|                                   ::|.|.|.:....|.|       :|...
Zfish   771 KS-----------------------------------EKESERQEVLGSKSLS-------KPHTV 793

  Fly   918 TKAELKGFTFTPPVLVTSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATDLGLDDEQHSLGN 982
            .|.|:....     ||...|:.|.      .|....|...:.| |||.|..:..|:.:|.
Zfish   794 NKDEIVCID-----LVQDDTDGSP------EPDKHSTIDAKCK-EPAKPVGSGTGMGNES----- 841

  Fly   983 LMDWGSTCNNLVEQLM-------------------SKVVVPPTLPANNPGIKL-----ELSEDDL 1023
                ||.......:||                   ::|..||. |.......|     |.|.:..
Zfish   842 ----GSNSEGKEPELMQILRSGQPAVSWPTDSEQRAEVCSPPR-PHKQSDSPLHSQSEESSSEHS 901

  Fly  1024 PVARILKRQPLAAPSLAGGDAESATTQLTTT---TNGISSSLGNGSGQKKLSKVEREK------- 1078
            |:..:|:.|.|.....:|..|.:...:....   ||.....||....:...|..:.|:
Zfish   902 PLPDMLEEQTLRCARTSGERARADGAEFRVDRHHTNRQYVDLGKDGLEDTESHEDEEEGHGCSKG 966

  Fly  1079 KRQQQEQRIAARLAPKQGQSSSSESD-----TTELHKRNT--ARQKKPLLRKGRTRQRSP----- 1131
            ||....:|||        .||....|     ||||:..::  :|:::.|..:|.:::.|.
Zfish   967 KRSSLAKRIA--------NSSGYVGDRFKCVTTELYADSSKLSREQRALQMEGLSQEDSNLSQPA 1023

  Fly  1132 ---EAASIQQSSDEEQEKVSQRLSRKPRTSSEESKTK--ATSAKKDVKKEAKTPSNKTNNSASLT 1191
               |.|.::.|..|.:||.....|..|....|:.:.:  |.|.......|...||::.  ||:|:
Zfish  1024 AFWERAMMRFSELELKEKEGCVSSAAPGLGREQERERELAESQHGAGDWERSQPSSRP--SAALS 1086

  Fly  1192 KIKKKTTDSSSLNKAKGDEN---------PKQESQESTSSESDQDDNDNDNDEEEEDQ------- 1240
            .:...|...:....|..:..         |....|...:.|.    ...|...|||..
Zfish  1087 ALSDSTEQRNGTTPACANNRVPVLQRCGLPADVLQPHRTEEK----RARDVKGEEEGSVGTATGR 1147

  Fly  1241 ------EEDEEEPEEEDDDEEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSKHRKELELQLANS 1299
                  |..:..|:.....||:|       |.||               ||.:....:..:.|.
Zfish  1148 KRALGLEHSQGHPDCTHTTEERD-------GERP---------------TRGEEDNGIASKRAR- 1189

  Fly  1300 KVLRNDKIIRNSTTKIKRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRNSKLKGSKVGNSP 1364
              |.:|...:.|..::|:..||..:...:......|.|.:.:....|.||....:...:.:|..|
Zfish  1190 --LISDVWPQPSEQEVKKLKVRIELTGLRLSKPRHLHNLQELWDRQGQLNHDRPQFGATNLGLPP 1252

  Fly  1365 GKPKTSPQQQLYLEEYRYKLALKIPHSLISINKLNKVASSLPDLERRDLSQELACFKRNRPKTKA 1429
            ....:.|..|....|.......::|          :||..:|.::|               |.|
Zfish  1253 TSKASIPPLQTTRREKLDPCTPEVP----------RVAHGVPAVDR---------------KVK- 1291

  Fly  1430 ASKQDFTPKSIIDVLHLRVTNG-STAGTQRKISVSAPASTNLQIHSETSQTSASTSLYEQSQQDN 1493
                               ||| ...|.:||..|            |...|..... |.:|....
Zfish  1292 -------------------TNGIEEKGLKRKAEV------------ERGWTKEQLE-YAESNTAI 1324

  Fly  1494 PTENQSLDDMSKRHF-SIFDTKVLQSKTRTETKLQKHREIIREIFVGPERPASAPPECV---QEA 1554
            |..:.|....|.|.| |......|..|.:   :|::||:     .||...| |..|:|.   :..
Zfish  1325 PALSDSFCSDSIRKFSSAVPPHHLSDKRQ---RLKEHRK-----SVGSSSP-SPDPDCTFPGRLR 1380

  Fly  1555 DGGDAISYQKYEEFLQQMNSIASANDSKLARRSLMEDKSVTAPQCPHKRKYRCRKGSSGFDYIRK 1619
            ..||       .|..:......:.:.|:..||.|::..:...|:.....:::..|.|:
Zfish  1381 RHGD-------PEKPKGKRQCKTKHLSQQERRMLLQSTNQECPELSPAHQHKVVKCSA------- 1431

  Fly  1620 KKRPAPTQTQNHTQNQSQSQVSSQITQHILEHNQSAA-DERLEDTDSTIAGSSHLP-----PKVK 1678
            :||||              .:|:..:..|..|..|.| ......|.........:|     |.|.
Zfish  1432 QKRPA--------------LLSNYESSPIKPHPPSPAYQPAASPTPPCAVADVPVPPLAPAPPVS 1482

  Fly  1679 TEMDVCR----EIQKWVLNKGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEAC 1739
            .|..|.|    |.::.::||..|::.:.:|||.|..:||:|||:....:.:.:|||||..|||||
Zfish  1483 AEPPVNRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEAC 1547

  Fly  1740 TQGWLEIARILLQYGANHSEAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLA 1804
            ::|||.|.:.||::||:.:.:||.|.||||.|:||||.:||||||||||||.||||||:..|.:.
Zfish  1548 SRGWLSIVQHLLEHGADINCSAQDGTRPLHDAVENDHLDVVRLLLSYGADPTLATYSGRGLLKMT 1612

  Fly  1805 SSKLMRGILRAHLSDAQSAAADIKPMRFNGPWEIFDA-------KEYGYDIFSNVPNTACDMSRA 1862
            .|.:|...|..:.:|.|....| .|..:   ||.:.:       ...||||.:|.|..
Zfish  1613 HSDIMECFLSDYFADLQGRVDD-DPSVY---WEFYGSAVCEPADDSSGYDILANPPGP------- 1666

  Fly  1863 LRKERKEAKQQRMSSNSDRTSNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTT 1927
                                                                             
Zfish  1667 ----------------------------------------------------------------- 1666

  Fly  1928 TATTMVKLELGTDEDSNNNKNNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKAN 1992
                      |.|||...
Zfish  1667 ----------GEDEDEQR----------------------------------------------- 1674

  Fly  1993 TNSSTRLDEDQTDIETMDSELNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVK 2054
                                   |:||||.:|.||.|.|.::   .:|...|:||:|:...||:.
Zfish  1675 -----------------------DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMS 1716

  Fly  2055 S---------------------KDTLLNKL--CPNNSNALASSQKHLLREFKIDDFLEKATCLQL 2096
            :                     |...|::|  ||..........|.||      |.:|
Zfish  1717 ARTFRATFTHIEVVTIAEAEFYKQASLSQLFSCPEELEGFMPDSKELL------DLVE------- 1768

  Fly  2097 LCAGEKLNMFSSS 2109
             .:||.:.:..||
Zfish  1769 -ISGELVALLGSS 1780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14073	NP_649060.1	PHA03247	<123..554	CDD:223021	102/499 (20%)
		TolA	1068..>1213	CDD:442298	37/177 (21%)
		ANKYR	<1686..1846	CDD:440430	71/166 (43%)
		ANK repeat	1697..1728	CDD:293786	10/30 (33%)
		ANK repeat	1730..1761	CDD:293786	16/30 (53%)
		ANK repeat	1763..1788	CDD:293786	18/24 (75%)
		PUFD_like	2016..2129	CDD:271222	31/120 (26%)
bcor	XP_005174000.1	BCOR	1214..1448	CDD:434953	61/328 (19%)
		ANKYR	<1503..>1609	CDD:440430	58/105 (55%)
		ANK repeat	1505..1536	CDD:293786	10/30 (33%)
		ANK repeat	1538..1569	CDD:293786	16/30 (53%)
		ANK repeat	1571..1600	CDD:293786	22/28 (79%)
		PUFD	1670..1786	CDD:271224	33/195 (17%)