DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14073 and Bcorl1

DIOPT Version :9

Sequence 1:	NP_001262022.1	Gene:	CG14073 / 40046	FlyBaseID:	FBgn0036814	Length:	2133	Species:	Drosophila melanogaster
Sequence 2:	NP_848897.3	Gene:	Bcorl1 / 320376	MGIID:	2443910	Length:	1781	Species:	Mus musculus

Alignment Length:	2264	Identity:	457/2264 - (20%)
Similarity:	713/2264 - (31%)	Gaps:	839/2264 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 GSGAAGTS---GSDPHMQYYTSNQNLAIKKMSDPHPMWSYKSQAVTTPAPAPG----LRQHGNPA 198
            ||.|.||:   .:...:.:.:.:|:      .||.|...|    |..||.|.|    |...|:..
Mouse    68 GSNARGTNPDGNTTEKLGHRSEDQS------DDPQPKMDY----VGNPAEAEGLLVPLSSPGDGL 122

  Fly   199 LYPT---------GSTAYWPPPDEQLHHQ---QP-------SRYSYAKPGGPV-----TGSRPIQ 239
            ..||         .:...|.|...|:..|   .|       ||:...:....:     ||. |::
Mouse   123 KLPTPDSTEASHSRANCSWTPLSTQMSKQVDCSPAGVKALDSRHGVGEKNTFILATLGTGV-PVE 186

  Fly   240 GPLPNSQRYYSEDIKYSTVPAASKVLTYAPPASSSQPQPPPPTSSSSANSSSVRHYELDVVNPSN 304
            |.||      .....:|.:||  .:...||.::|..|..|.|.....:..:.|.|..|   .|..
Mouse   187 GTLP------LVTTNFSQLPA--PICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGL---VPVQ 240

  Fly   305 PSNEHQQPSPNYGRKCPPHYETPPEQRSAGATPN--STGTPTSTSHHQSLYIPMPTFSTEKFQTT 367
            .:.....||             ||...:|.:.|.  |...|.|.|  .|:.:|:|..:..
Mouse   241 VATSASAPS-------------PPLAPAAPSVPTLISDSNPLSVS--ASVLVPVPVSAPH----- 285

  Fly   368 VHNAIEKYIRETPGPSLEYPRGGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYVKMEPEHALA 432
                           |:..|....||...|...:..|:...:||  ||.:|.:..:...|...||
Mouse   286 ---------------SVPVPLSAPAPTPLTVSVSAPPLALIQAP--VPPSAPTLVLASVPTPVLA 333

  Fly   433 GGLPQPTRSSLYHNPYNVESRERDSSPAMATV----PAPHGYPTKYGKLIQQQHAASGVGTGSSA 493
               |.|..:.             .::||..:|    |.|...|.....|| ...|.:.|...:.|
Mouse   334 ---PMPASTP-------------PAAPAPPSVPMPTPTPSSGPPSTPTLI-PAFAPTPVPAPTPA 381

  Fly   494 PYQSYYHQGTPSPAAGAVASPTPAPLP----------PLAEAPG-----TIFGPGTGLNPGIPPH 543
            |.  :....||.|||...|.||.||:|          |.|:||.     ..|.|||.|.|
Mouse   382 PI--FTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTP----- 439

  Fly   544 SSQP---VPPPANSQQ------PASSSSSSNANFSTLQVYPH------------GPDI------- 580
             :||   :|||:..|.      |.:...||..   ||.|.|.            .||:
Mouse   440 -NQPLVYIPPPSCGQPLSVATLPTTLGVSSTL---TLPVLPSYLQDRCLPGVLASPDLRSYPCAF 500

  Fly   581 ---------------------CYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNYRALINDMLKRNT 624
                                 |..|.|.|.:|......|.|...: ::|..:.:.|....|
Mouse   501 SVARPLASDSKLVSLEVNRLSCTSPSSSTNSQPAPDGVPGPLADT-SLTTASAKVLPTSQL---- 560

  Fly   625 ASEQELNLQIIKKTLNMEPASSRNHSAPSRV----IQQSAAPAAISIPSAPPP--------PPPA 677
                          |...|:.|.....||::    .||:...:....|...||        ||..
Mouse   561 --------------LLPAPSGSSVPPHPSKMPGGTDQQTEGTSVTFSPLKSPPQLEREMASPPEC 611

  Fly   678 IHSPLDLSMRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPNFSAAT--------- 733
            ...|||||.::.:|                |||         ||....||.....|
Mouse   612 SEMPLDLSAKSNRQ----------------KLP---------LPNQRKTPPMPVLTPVHTSSKAL 651

  Fly   734 --------------RG-------GAPTSP-----------APTPVIRQAVAIQPAPVPPTV---- 762
                          .|       |:.:||           .|:..::.:.|: .:.:|.|.
Mouse   652 LSTVLSRSQRTTQAAGSNVTSCLGSTSSPFVIFPEMVRNGDPSTWVKNSTAL-ISTIPGTYVGVA 715

  Fly   763 -PVPPAVAA---PAL-------------VIKTVQQMRP-------------SVVETNPFAKRQQQ 797
             |||.::..   |.|             .|..:.|..|             :..|..|...:.:.
Mouse   716 NPVPASLLLNKDPNLGLNRDPRHLPKQEPISIIDQGEPKSTSATCGKKGSQAGAEGQPSTVKSRY 780

  Fly   798 LPP---------ETSIVQVTKPTVELMPTPSPSPHNSSNPNYLGKKRHLQ-------EYNQAAAK 846
            .|.         :|..:.:.|||    ...:..|..|.|    ||....|       .|:||:.
Mouse   781 TPARIAPGLPGCQTKELSLWKPT----GLTNMYPRCSIN----GKPTSTQVLPVGWSPYHQASL- 836

  Fly   847 QARLDAESSGSLVSGAPVIAAPTSVVVVAPVPVIAVNEQALAAKREREMQSMS-AESSTSAHLVP 910
             ..:...|:|.|.....|...|||:|                    .|...:| ..||.:.|.:|
Mouse   837 -LSIGISSAGQLTPSQGVPIRPTSIV--------------------SEFSGVSPLGSSETVHGLP 880

  Fly   911 KMEPRIRTKAELKGFTFTPPV-LVTSTTNASSTISPPRTPPNQITNHIQIKLEP--------APP 966
            :.:||       .|..|.|.. .||...|......    |..:..|.:.:.|.|        ..|
Mouse   881 EGQPR-------PGGPFAPEQDAVTKNKNCRIAAK----PYEEQVNPVLLTLSPQSGTLALSVQP 934

  Fly   967 KATDLGL-----DDEQHSLGNLMDWGSTCNNLVEQLMSKVVVPPTLPANNPGIKLELSEDDLPVA 1026
            .:.|:|:     :.|.|          .|::..          |.:........|:|:.|..|..
Mouse   935 SSGDMGVNQGSEESESH----------LCSDST----------PKMEGPQAACGLKLAGDTKPKN 979

  Fly  1027 RIL-----KRQPLAAPS---------LAGGDAESATTQL---TTTTNGISSSLGNGSGQKKLSKV 1074
            ::|     ....||.|.         |...|:.|....|   .::..|.|:.|.....|..|.:|
Mouse   980 QVLATYMSHELVLANPQNLCKMPELPLLPHDSHSKELILDVVPSSERGPSTDLSQLGSQVDLGRV 1044

  Fly  1075 EREKKRQQQEQRIAARLA-----------PKQGQSSSSESDTTELHKRNTARQKKPLLRKGRTRQ 1128
            :.||    .:..:...||           |::||:.:          |..|.|       .|.::
Mouse  1045 KMEK----ADGDVVFNLANCFRADGLPAVPQRGQAEA----------RANAGQ-------ARVKR 1088

  Fly  1129 RSPEAASIQQSSDEEQEKVSQRLSRKPRTSSEESKTKATSAKKDVKKEAK-----TPSNKTNNSA 1188
            .|....:.:.|...::|           |.|...|....:.:|::::|.:     .|.:|....:
Mouse  1089 ESIGVFTCKNSWQPDEE-----------TESLPPKKVKCNKEKEIEEEPRQQPPPQPHDKPMVRS 1142

  Fly  1189 SLTKIKKKTTDSSSLNKAKGDENPKQESQESTSSESDQDDNDNDNDEEEEDQEEDEEEPEEEDDD 1253
            ||         .|...|..||  |::.:::  |.....|.....|....:.:.....:||.:...
Mouse  1143 SL---------GSKCRKLPGD--PQEPTKK--SPRGALDSGKEHNGVRGKHKHRKPTKPESQPPG 1194

  Fly  1254 EEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSKHRK-------ELELQLANSKVLRNDKIIRNS 1311
            :..|..:|..:.::..|:.:..|...|:|.|||:...       ..:..:.:.:|...::....:
Mouse  1195 KRTDGHEEGSLEKKAKNSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVA 1259

  Fly  1312 TTKIKRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRNSKLKGSKVGNSPGKPKTSPQQQLY 1376
            .|..||:.|||   ::::   |:.|:....:..| ...||....:..::   |.:.:.:.|....
Mouse  1260 PTPAKRRKVRK---TQRD---TQYRSHHAQDKTL-LSQGRRHLWRAREM---PWRTEAARQMWDT 1314

  Fly  1377 LEEYRYKLALKIPHSLISINKLNKVASSLPDLERRDLSQELACFKRNRPKTKAASKQDFTPKSII 1441
            .||..                         |.|...|.:..   ||.|.|::.....::
Mouse  1315 NEEEE-------------------------DDEEEGLVKRK---KRRRQKSRKYQTGEY------ 1345

  Fly  1442 DVLHLRVTNGSTAGTQRKISVSAPASTNLQIHSETSQTSASTSLYEQSQQDNPTENQSLDDMSKR 1506
                                                       |.||.:|
Mouse  1346 -------------------------------------------LIEQEEQ--------------- 1352

  Fly  1507 HFSIFDTKVLQSKTRTETKLQKHREIIREIFVGPERPASAPPECVQEADGGDAISYQKYEEFLQQ 1571
                      :.|.|.::|.:|.:                             .|.|..|..|:.
Mouse  1353 ----------RRKGRADSKARKQK-----------------------------TSSQSSEHCLRN 1378

  Fly  1572 MNSIASANDSKLARR-------SLMEDKSVTAPQCPH-KRKYRCRKGSSGFDYIRKKKRPAPTQT 1628
            .|.:.|:....::..       :|.|...:..|:.|. |||.:.:..::..:..|.|.|.:..:|
Mouse  1379 RNLLLSSKAQGISDSPNGFLPDNLEEPACLENPEKPSGKRKCKTKHMANASEEARSKGRWSQQKT 1443

  Fly  1629 QNHTQNQSQSQVSSQITQHILEHN-QSAADERLEDTDSTIAGSSHLPPKVKTEMDVCREIQKWVL 1692
            ::     |:|....:.|:...... :||..|...::.:    :..:||          |.::.::
Mouse  1444 RS-----SKSPTPVKPTEPCTPSKYRSAGPEEASESPT----ARQIPP----------EARRLIV 1489

  Fly  1693 NKGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWLEIARILLQYGANH 1757
            ||..|::.:.:|||.|..|||:|||.:.:.:.:.:||||||.|||||::||.:|..||||:|||.
Mouse  1490 NKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANV 1554

  Fly  1758 SEAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLMRGILRAHLSDAQS 1822
            :.::|.|.||:|.|:.||:.|.:.|||||||||.||||||||.:.||||..|:..|..||||.|
Mouse  1555 NCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDHLSDLQ- 1618

  Fly  1823 AAADIKPMRFNGPWEIFDAKEYGYDIFSNVPNTACDMSRALRKERKEAKQQRMSSNSDRTSNLNG 1887
            ..|:..|   ...|:.     |...:.......|||:..
Mouse  1619 GRAEGDP---RASWDF-----YSSSVLEKKDGFACDLLH-------------------------- 1649

  Fly  1888 LLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTTTATTMVKLELGTDEDSNNNKNNEEL 1952
                                           ...|||           |.|.|.:.
Mouse  1650 -------------------------------NPPGSA-----------EQGDDSEQ--------- 1663

  Fly  1953 NANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKANTNSSTRLDEDQTDIETMDSELNGDI 2017
                                                                           |.
Mouse  1664 ---------------------------------------------------------------DD 1665

  Fly  2018 FEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVKSKDTLLNKLCPNNSNALASSQKHL- 2078
            |.||.:|.||.|.|.|:   ..|...|.|.:|:...||:.|:  :.....|           ||
Mouse  1666 FMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSR--IFQARFP-----------HLE 1717

  Fly  2079 LREFKIDDFLEKATCLQLLCAGEKLNMF-------SSSKVVLIKYNDSVRNLLG 2125
            :......:|..:....|||...|:....       ||..|.|::|...:..|||
Mouse  1718 ITTLPKAEFYRQVASSQLLSPAERPGSLEDRSPPGSSETVELVQYEPELLRLLG 1771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14073	NP_001262022.1	ANK	1697..1807	CDD:238125	61/109 (56%)
		ANK repeat	1697..1728	CDD:293786	11/30 (37%)
		Ank_2	1702..1790	CDD:289560	47/87 (54%)
		ANK repeat	1730..1761	CDD:293786	19/30 (63%)
		ANK repeat	1763..1788	CDD:293786	13/24 (54%)
		PUFD_like	2016..2129	CDD:271222	33/121 (27%)
Bcorl1	NP_848897.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..136		19/77 (25%)
		PHA03247	<182..630	CDD:223021	126/568 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..362		6/37 (16%)
		Herpes_BLLF1	<442..833	CDD:282904	80/446 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..616		12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	733..777		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..960		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1484		85/567 (15%)
		ANK 1	1493..1523		11/29 (38%)
		ANK repeat	1494..1525	CDD:293786	11/30 (37%)
		Ank_2	1498..1589	CDD:403870	49/90 (54%)
		ANK repeat	1527..1558	CDD:293786	19/30 (63%)
		ANK 2	1527..1556		19/28 (68%)
		ANK repeat	1560..1589	CDD:293786	17/28 (61%)
		ANK 3	1560..1589		17/28 (61%)
		PUFD_like_1	1662..1775	CDD:271223	33/195 (17%)
		PCGF Ub-like fold domain (PUFD), required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000250\|UniProtKB:Q5H9F3	1664..1781		33/121 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2AIVP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3148
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008249
OrthoInspector	1	1.000	-	-		otm42444
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9799
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920