Protein Alignment CG14073 and Bcor

DIOPT Version :10

• Sequence 1: NP_649060.1
• Gene: CG14073 / 40046
• FlyBaseID: FBgn0036814
• Length: 2133
• Species: Drosophila melanogaster
• Sequence 2: NP_001178515.1
• Gene: Bcor / 317346
• RGDID: 1562735
• Length: 1757
• Species: Rattus norvegicus
• Alignment Length: 2153
• Identity: 440/2153 - (20%)
• Similarity: 688/2153 - (31%)
• Gaps: 810/2153 - (37%)

  Fly   273 SSQPQPPPPTSSSSANSSSVRHYELDVVNPSNPSNEHQQPSPNYGRKCPPH-----YETPPE-QR 331
            |.:.:...|:|.|....||.|:.|:. ..|:.|  |..:.|...|:  ||:     |:|||. |:
  Rat    98 SEKGREATPSSLSGLGFSSERNPEMQ-FKPNTP--ETVEASAVSGK--PPNGFSAIYKTPPGIQK 157

  Fly   332 SAGATPNSTGTPTSTSHHQS-------LYIPMPTFSTEKFQTTVHNAIEKYIR-ETPG--PSLEY 386
            ||.||..|.|.....|..||       .|:.:|.             :..|:. .||.  |.|:.
  Rat   158 SAVATAESLGLDRPASDKQSPLNINGASYLRLPW-------------VNPYMEGATPAIYPFLDS 209

  Fly   387 PRGGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYVKMEPEHALAGGLPQPTRSSLYHNPYNVE 451
            |             |:..:...||  .:||   .||           ||.||..|.:      ..
  Rat   210 P-------------NKYSLNMYKA--LLPQ---QSY-----------GLAQPLYSPV------CT 239

  Fly   452 SRERDSSPAMATVPAPHGYPTKYGKLIQQQHAASGVGTGSSAPYQSYYHQGTPSPAAGAVASPTP 516
            |.||     ...:|.||                             |.:...||..|..:...||
  Rat   240 SGER-----FLYLPPPH-----------------------------YVNPHIPSSLASPMRLSTP 270

  Fly   517 ---APLPPLAEAPGTIFGPGTGLNPGIP------PH---SSQP-------------------VPP 550
               |.:|||............|:|||.|      ||   |.||                   :||
  Rat   271 SASAAIPPLVHCSDKSLPWKMGVNPGNPVDSHTYPHIQNSKQPRVTSAKAVNSGLPGDAALLLPP 335

  Fly   551 -PANS------QQPASSSSSSNANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKK----- 603
             |..|      .|||:.|.|        :.:.|.|.|...|.........|.:...|..:
  Rat   336 SPRPSTRVHLPTQPAAESYS--------EFHKHYPRISTSPSVTLTKPYMTASSEFPTARLSSGK 392

  Fly   604 ----------SPAVTKPNYRALINDMLKRNTASEQELNLQIIKKTLNMEP-----------ASSR 647
                      :|:::..:.:..:.|  :::..|...|..|.:.|.:..:|           .|..
  Rat   393 YPKALDGGDCAPSMSGHSRKTTVQD--RKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDVDTSKT 455

  Fly   648 NH---SAPSRVIQQSAAPAAI----SIPSAPPPPPPAIHSPLDLSMRTVKQTADST--------- 696
            :|   .||:.::...|....:    .||....||    .:...:....:..||.|:
  Rat   456 DHMKKMAPTVLVHSRATSGLVLSGSEIPKETSPP----GNGCSIYRSEIISTAPSSWVVPGPSPN 516

  Fly   697 ------EYKYQRPSTDYKLPQGGLG-----GGLGLPRFDITPNFSAATRGGAPTSPAP------T 744
                  ....:..:.|:.:||....     ||......:::.:.|::.| .|..||||      |
  Rat   517 EENNGKSLSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSSGR-PASASPAPNANADGT 580

  Fly   745 PVIRQAVAIQPAPV-----PPTVPVPPAVAAPALVIKTVQQMRPSVVETNP---FAKRQQQLPPE 801
            ...|.:|...|:.:     ||:.|...:.:..:...|.          :||   |...:..|||
  Rat   581 KTSRSSVDTTPSVIQHVGQPPSTPAKHSGSTSSKGAKA----------SNPEPSFKASENGLPP- 634

  Fly   802 TSIVQVTKPTVELMPTPSPSPHNSSNPNYLGKKRHLQEYNQAAAKQARLDAESSGSLVSGAPVIA 866
            |||  ...|.......|.|.|               :.|....|.:.  .|.|..||....||.
  Rat   635 TSI--FLSPNEAFRSPPIPYP---------------RSYLPYPAPEG--IALSPLSLHGKGPVY- 679

  Fly   867 APTSVVVVAPVPVIAVNEQALAAKREREMQSMSAESSTSAHLVPK---------MEPRIRTKAEL 922
                     |.||:..|                 .|....||.||         ..|...|..:.
  Rat   680 ---------PHPVLLPN-----------------GSLFPGHLAPKPGLPYGLHTSRPEFVTYQDA 718

  Fly   923 KGFTFTPPVLVTSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATDLGLDDEQHSLGNLMDWG 987
            .|.....|:|:            |.||       |:|..|..|.:.:      ..|......|
  Rat   719 LGLGMVHPMLI------------PHTP-------IEITKEEKPERRS------RSHERARYED-- 756

  Fly   988 STCNNLVEQLMSKVVVPPTLPANNPGIKLELS----EDDLPVARILKRQPLAAPSLAGGDAESAT 1048
                             |||.:....| ||.|    ..|:|..:.||..|
  Rat   757 -----------------PTLRSRFSEI-LEASSAKLHPDVPTEKNLKPNP--------------- 788

  Fly  1049 TQLTTTTNGISSSLGNG-SGQKKLSKVEREKKRQQQEQRIAARLAPKQGQSSSSESDTTELHKRN 1112
                        |...| :|.|....|..:..|::.|.:..|. |.|.|..:.:....|:..|.:
  Rat   789 ------------SWNQGKTGAKSDKLVYVDLLREETEAKADAG-ASKAGLVAENAGQNTDAAKPS 840

  Fly  1113 TARQKKPLLRKGRTRQRSPEAASIQQS----SDEEQEKVSQRLSRKPRTSSEESKTKATSAKKDV 1173
            .    .|::::.|      |..|:::.    :|..:....::...:|..|..:....|.|.|:::
  Rat   841 A----DPVIQQHR------EFISLREELGRITDFHESFTFKQAPGQPVFSLGKDSVAAGSNKENL 895

  Fly  1174 KKEAKTPSNKTNNSASLTKIKKKTTDSSSLNKAKGDENPK-------QESQESTSSESDQDDNDN 1231
            ..:..||..:|          ...::..::...|..|:||       ..|.:.|.:.: :|..|
  Rat   896 GVQVATPFLET----------ALGSEGPAVTFGKTQEDPKPFCVGGAPPSMDVTPAYT-KDGTD- 948

  Fly  1232 DNDEEEEDQEEDEEEPEEEDDDEEQDKKKEKRVGRRPGNTLK------KRIAHKLNTMTRSKHRK 1290
                            |.|.:|.:..|.|..::.:|..|:..      |.:..:|...:....|:
  Rat   949 ----------------EAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSRE 997

  Fly  1291 ELELQLANSKVLRNDKIIRNSTTKIKRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRN-SK 1354
            :..||:..   |:.|.|:.......:|..:|   .|:.||....:.:....:|::...:..: .:
  Rat   998 QRALQMEG---LQEDSILCLPAAYCERAMMR---FSELEMKEREVSHPATKDSEVCKFSPADWER 1056

  Fly  1355 LKGSKVGNSPGKPKTSPQQQLYLEEYRYKLALKIPHSLISINKLNKVASSLPDLERRDLSQELAC 1419
            ||    ||...|||:     :.|||              :|...|       |.||.|      |
  Rat  1057 LK----GNQEKKPKS-----VALEE--------------AIADQN-------DTERCD------C 1085

  Fly  1420 FKRNR------PKTKAASKQDF-----------TPKSIIDVLHLRVTNGSTAGTQRKISVSAPAS 1467
            ...|:      |:.|....:.:           |.:.::|:.|     ..|....||...|..::
  Rat  1086 STGNKHDLFEAPEDKDLPVEKYFLERPPVSEPPTDQGVVDMSH-----SPTLRLDRKRKASGDST 1145

  Fly  1468 TNLQIHSET-----SQTSASTSLYEQSQQDNPTE---NQSLDDMSKRHFS-IFDTKVLQSKTRTE 1523
                 |:||     ::..........|:.|.|..   |.|.:.:...|.: :.:.||....|...
  Rat  1146 -----HTETTVEELTEDPLKAKRRRISKDDWPEREMTNSSSNHLEDPHCNELTNLKVCIELTGLH 1205

  Fly  1524 TKLQKHREIIREIFVGPERPASAPP---------ECVQ--------------------EADGGDA 1559
            .|.|:|...:||.:......|.:.|         :.||                    ||.|...
  Rat  1206 PKKQRHLLHLRERWEQQVSAAESKPGRQSRKEVTQAVQPEVTSQGNNITEERPGRKKAEAKGNRG 1270

  Fly  1560 ISYQKYEEFLQQ---------------MNSIASANDSKLARRSLMEDKSVTAPQC------PHKR 1603
            .|    ||.|:.               |.|::|.|.|         .|..|.|.|      |.|:
  Rat  1271 WS----EESLKSCDNEQGLPVFSASPPMKSLSSTNAS---------GKKQTQPSCTPASRPPAKQ 1322

  Fly  1604 K----------------YRCRKGS----------------------------------SGFDYI- 1617
            :                ..||..|                                  :|..|:
  Rat  1323 QKIKESQKTDVLCTEEDEDCRAASPLQKYTDNIEKPSGKRLCKTKHLIPQDSRRSVQITGEYYVE 1387

  Fly  1618 ---------RKKKRPAPTQTQNHTQNQSQSQVSSQITQHILEHNQSAADERLEDTDSTIAGSSHL 1673
                     |.:|||.|:...:.:....|........|.:|...|:....|......| ..|..:
  Rat  1388 NTDTKMTVRRFRKRPEPSTDYDLSPPAKQEPKPFDRLQQLLPATQATQLPRSNSPQET-TQSRPM 1451

  Fly  1674 PPKVKTEMDVCREIQKWVLNKGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEA 1738
            ||          |.::.::||..|::.:.:|||.|..:||:|||:....:.:.:|||||..||||
  Rat  1452 PP----------EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEA 1506

  Fly  1739 CTQGWLEIARILLQYGANHSEAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLML 1803
            |.:|||.|.|.||:|||:.:.:||.|.||||.|:||||.|:|||||||||||.||||||:|.:.:
  Rat  1507 CARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKM 1571

  Fly  1804 ASSKLMRGILRAHLSDAQSAAADIKPMRFNGPWEIFDAK------EYGYDIFSNVPNTACDMSRA 1862
            ..|:||...|..:|:|.|..:.:    ..:|.||.:.:.      |.|||:.:|.|.
  Rat  1572 THSELMEKFLTDYLNDLQGRSEE----DTSGAWEFYGSSVCEPDDESGYDVLANPPG-------- 1624

  Fly  1863 LRKERKEAKQQRMSSNSDRTSNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTT 1927
                                               |||.|:
  Rat  1625 -----------------------------------PEDPDE------------------------ 1630

  Fly  1928 TATTMVKLELGTDEDSNNNKNNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKAN 1992
                        :||:.:
  Rat  1631 ------------EEDAYS----------------------------------------------- 1636

  Fly  1993 TNSSTRLDEDQTDIETMDSELNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVK 2054
                                   |:||||.|:..|.|.|.::   .:|...|:||:|:...||:.
  Rat  1637 -----------------------DMFEFEFAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMS 1678

  Fly  2055 SKDTLLNKLCPNNSNALASSQKHLLREFKIDDFLEKATCLQLLCAG--EKLNMFSSSKVVLIKYN 2117
            |:....|  .||         ..::...:.:.:.:.:|.|...|..  |..|......:.|:::.
  Rat  1679 SRIFRCN--FPN---------MEIVSIAEAEFYRQVSTSLLFSCPKDLEAFNPEGKELLDLVEFT 1732

  Fly  2118 DSVRNLLG 2125
            :.::.|||
  Rat  1733 NELQTLLG 1740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14073	NP_649060.1	PHA03247	<123..554	CDD:223021	78/328 (24%)
		TolA	1068..>1213	CDD:442298	25/148 (17%)
		ANKYR	<1686..1846	CDD:440430	75/165 (45%)
		ANK repeat	1697..1728	CDD:293786	10/30 (33%)
		ANK repeat	1730..1761	CDD:293786	18/30 (60%)
		ANK repeat	1763..1788	CDD:293786	18/24 (75%)
		PUFD_like	2016..2129	CDD:271222	29/115 (25%)
Bcor	NP_001178515.1	Herpes_BLLF1	<257..672	CDD:282904	90/459 (20%)
		BCOR	1203..1415	CDD:434953	37/224 (17%)
		ANKYR	<1463..1596	CDD:440430	68/136 (50%)
		ANK repeat	1465..1496	CDD:293786	10/30 (33%)
		ANK repeat	1498..1529	CDD:293786	18/30 (60%)
		ANK repeat	1531..1560	CDD:293786	22/28 (79%)
		PUFD	1636..1749	CDD:465171	29/186 (16%)