Protein Alignment CG14073 and Bcorl1

DIOPT Version :10

• Sequence 1: NP_649060.1
• Gene: CG14073 / 40046
• FlyBaseID: FBgn0036814
• Length: 2133
• Species: Drosophila melanogaster
• Sequence 2: NP_001178516.1
• Gene: Bcorl1 / 302810
• RGDID: 1566108
• Length: 1788
• Species: Rattus norvegicus
• Alignment Length: 2250
• Identity: 472/2250 - (20%)
• Similarity: 727/2250 - (32%)
• Gaps: 804/2250 - (35%)

  Fly   141 GSGAAGTS--GSDPHMQYYTSNQNLAIKKMSDPHPMWSY-----KSQAVTTPAPAPGLRQHGNPA 198
            ||.|.||:  ||......:.|..     :..||.....|     :::.:..|..:|     |:..
  Rat    68 GSNARGTNPDGSTTEKLGHRSED-----QPDDPQAKMDYVGNTAEAEGLLVPLSSP-----GDSL 122

  Fly   199 LYPT--GSTA-------YWPPPDEQLHHQ---QP-------SRYSYAKPGGPV-----TGSRPIQ 239
            ..||  |:.|       .|.|...|:..|   .|       ||:|..:....:     ||. |::
  Rat   123 KLPTPDGTEASHSRANCSWTPLSTQMSKQVDCSPAGVKALDSRHSVGEKNTFILATLGTGV-PVE 186

  Fly   240 GPLPNSQRYYSEDIKYSTVPAASKVLTYAPPASSSQPQPPPPTSSSSANSSSVRHYELDVVNPSN 304
            |.||      .....:|.:||  .:...||.::|..|..|.|.....:..:.|.|..|   .|..
  Rat   187 GTLP------LVTTNFSQLPA--PICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGL---VPVQ 240

  Fly   305 PSNEHQQPSPNYGRKCPPHYETPPEQRSAGATPN--STGTPTSTSHHQSLYIPMPTFSTEKFQTT 367
            .:.....||       ||....|....:|.:.|.  |...|.|.|  .|:.:|:|..:..
  Rat   241 VATSASAPS-------PPLAPVPALAPAAPSVPTLISDSNPLSVS--ASVLVPVPVSAPH----- 291

  Fly   368 VHNAIEKYIRETPGPSLEYPRGGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYVKMEPEHALA 432
                           |:..|....||...|...:..|:...:||  ||.:|.:..:...|...||
  Rat   292 ---------------SVPVPLSAPAPTPLTVSVSAPPLALIQAP--VPPSAPTLVLASVPTPVLA 339

  Fly   433 GGLPQPTRSSLYHNPYNVESRERDSSPAMATV----PAPHGYPTKYGKLIQQQHAASGVGTGSSA 493
               |.|..:.             .::||..:|    |.|...|.....|| ...|.:.|...:.|
  Rat   340 ---PMPASTP-------------PAAPAPPSVPMPTPTPSSGPPSTPTLI-PAFAPTPVPAPTPA 387

  Fly   494 PYQSYYHQGTPSPAAGAVASPTPAPLP----------PLAEAPG-----TIFGPGTGLNPGIPPH 543
            |.  :....||.|||...|.||.||:|          |.|:||.     ..|.|||.|.|
  Rat   388 PI--FTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTP----- 445

  Fly   544 SSQP---VPPPANSQQ------PASSSSSSNANFSTLQVYP-HGPDICYQPGSQTQAQNQTQNHP 598
             :||   :|||:..|.      |.:...||..   ||.|.| :..|.|. ||  ..|..:.:::|
  Rat   446 -NQPLVYIPPPSCGQPLSVATLPTTLGVSSTL---TLPVLPSYLQDRCL-PG--VLASPELRSYP 503

  Fly   599 NPAKKSPAVTKPNYRALINDMLKRNTASEQELNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPA 663
                .:.:|.:|             .||:.:|....:.:.....|:||.|..
  Rat   504 ----YAFSVARP-------------LASDSKLVSLEVNRLSCTSPSSSTNSQ------------- 538

  Fly   664 AISIPSAPPPPPPAIHSPLDLSMRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPN 728
                     |.|..:..||          ||
  Rat   539 ---------PAPEGVPGPL----------AD---------------------------------- 550

  Fly   729 FSAATRGGAPTSPAPTPVIRQAVAIQPAPVPPTVPVPPAVAAPALVIKTVQQMRPSVVETNPF-- 791
             ::.|...|...|...|::       |||...:||:.|:.....    |.||...:.|..:|.
  Rat   551 -TSLTTASAKVLPTSQPLL-------PAPSGSSVPLHPSKMPGG----TDQQTEGTSVTFSPLKS 603

  Fly   792 ---AKRQQQLPPETSIVQV---TKPTVELMPTPS-----PSP-----HNSSNPNYLGKKRHLQEY 840
               .:|:...|||.|.:.:   :|...:.:|.|:     |.|     |.||...........|..
  Rat   604 PPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRT 668

  Fly   841 NQAAAKQAR--LDAESSGSLV----------------SGAPVIAAPTSVVVVA-PVPV-IAVNEQ 885
            .|||.....  |.:.||..::                |.|.:...|.:.|.|| |||. :.:|:.
  Rat   669 TQAAGSNVTSCLGSTSSPFVIFPEMVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKD 733

  Fly   886 A-LAAKREREMQSMSAESSTSAHLVPKMEP-RIRTKAELK--GFTFTPPVLVTSTTNASSTISPP 946
            . |...|:            ..|| ||.|| .|..:.|.|  |.|........:.....||:...
  Rat   734 PNLGLNRD------------PRHL-PKQEPISIIDQGEPKSTGVTCGKKGSQVAAEGQPSTVKSR 785

  Fly   947 RTPPNQITNHIQIKLEPAPPKATDLGLDDEQHSLGNLMDWGST-CNNLVEQLMSKVVVPPTLPAN 1010
            .||         .::.|..|     |...::.||     |..| ..|:.          |....|
  Rat   786 YTP---------ARIAPGLP-----GCQTKELSL-----WKPTGLTNMY----------PRCSIN 821

  Fly  1011 NPGIKLELSEDDLPVARILKRQPLAAPSLAGGDAESA------------TTQLTTTTNGISSSLG 1063
            .   |...::..|||.    ..|....||......||            .|.:.:..:|: ||||
  Rat   822 G---KPTSTQQVLPVG----WSPYHQASLLSIGISSAGQLTPSQGVPLRPTSIVSEFSGV-SSLG 878

  Fly  1064 NGSGQKKLSK----------VEREKKRQQQEQRIAAR------------LAPKQGQ--------- 1097
            :......|.:          .|::...:.:..||||:            |:|:.|.
  Rat   879 SSEAVHGLPEGQPRPGGPFAPEQDAVTKNKTCRIAAKPYEEQVNPVLLTLSPQTGTLALSVQPNS 943

  Fly  1098 -----SSSSESDTTELHKRNTARQKKP-----LLRKGRTRQRSPEAASIQQSSDEEQEKVSQRLS 1152
                 :..||...:.|...:|.:.:.|     |...|.|:.:|...|:..  |.|......|.|.
  Rat   944 GDIGVNQGSEESESHLCSDSTPKVEGPQAACGLKLAGDTKPKSQVLATYM--SHELVLANPQNLC 1006

  Fly  1153 RKPR----TSSEESKTKATSAKKDVKKEAKTPSNKTNNSASLTKIKKKTTDSSSL----NKAKGD 1209
            :.|.    .....||..........::...|..::..:...|.::|.:..|...:    |..:.|
  Rat  1007 KMPELPLLPHDSHSKELILDVVPSSERGPSTDLSQLGSQVDLGRVKMEKADGDVVFNLANCFRAD 1071

  Fly  1210 ENP--KQESQESTSSESDQD------------DNDNDNDEEEED----------QEEDEEEPEEE 1250
            ..|  .|..|....:::.|.            .|....|||.|.          ::|.||||:::
  Rat  1072 GLPAVPQRGQAEARAKAGQARVKREGVGVFTCKNSWQPDEETESLPPKKVKCNKEKEIEEEPQQQ 1136

  Fly  1251 DDDEEQDKKKEKRVGRRPGNTLKKRIAHKLNTMTRSKHRKELELQLANSKVLRNDKIIRNSTTKI 1315
            ...:..||.                   .:.:...||.||                 :.....:.
  Rat  1137 LPPQPHDKP-------------------MVRSSVGSKCRK-----------------LPGDPQEP 1165

  Fly  1316 KRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRNSKLKGSKVGNSPGKPKTSPQQQLYLEEY 1380
            .:|..|..:||.||.                  ||...|.|..|    |.||:
  Rat  1166 TKKSPRGALDSGKEH------------------NGVRGKHKHRK----PTKPE------------ 1196

  Fly  1381 RYKLALKIPHSLISINKLNKVASSLPDLERRDLSQELACFKRNRPKTKAASKQDFTPKSIIDVLH 1445
                                   |||..:|.|..:|.:..|:.:     :|.:||.|  ::....
  Rat  1197 -----------------------SLPAGKRADGHEEGSLEKKAK-----SSFRDFIP--VVLSTR 1231

  Fly  1446 LRVTNGSTAGTQRKISVSAPASTNL---QIHSETSQTSASTSLYEQSQQD-----NPTENQSLDD 1502
            .|..:||...:...::.|...|..:   :...|.:.|.|......::|:|     :..::::|..
  Rat  1232 TRSQSGSICSSFTGLADSDMGSQEVFPTEEEEEVAPTPAKRRKVRKTQRDTQYRSHHAQDKTLLS 1296

  Fly  1503 MSKRHF--------------SIFDTK----------VLQSKTRTETKLQKHREIIREIFVGPERP 1543
            ..:||.              .::||.          :::.|.|...|.:|::.
  Rat  1297 QGRRHLWRAREMPWRTEAARQMWDTNEEEEDEEEEGLVKRKKRRRQKSRKYQT------------ 1349

  Fly  1544 ASAPPECVQEADGGDAISYQKYEEFLQQMNSIASANDSKLARRS----------LMEDK------ 1592
                         |:.::.|  ||..::..:.:.|...|.:.:|          |:..|
  Rat  1350 -------------GEYLTEQ--EEQRRKGRADSKARKQKTSSQSSEHCLRNRDLLLSSKAQGISD 1399

  Fly  1593 --------SVTAPQC-------PHKRKYRCRKGSSGFDYIRKKKRPAPTQTQNHTQNQSQSQVSS 1642
                    ::..|.|       ..|||.:.:..::..:..|.|.|.:..:|::     |:|....
  Rat  1400 SPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMANVSEEARSKGRWSQQKTRS-----SKSPTPV 1459

  Fly  1643 QITQHILEHN-QSAADERLEDTDSTIAGSSHLPPKVKTEMDVCREIQKWVLNKGVGQSTMHKAAR 1706
            :.|:...... :||..|  |.::|..|  ..:||          |.::.::||..|::.:.:|||
  Rat  1460 KPTEPCTPSKYRSAGSE--ETSESPTA--RQIPP----------EARRLIVNKNAGETLLQRAAR 1510

  Fly  1707 QGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWLEIARILLQYGANHSEAAQSGIRPLHGA 1771
            .|..|||:|||.:.:.:.:.:||||||.|||||::||.:|..||||:|||.:.::|.|.||:|.|
  Rat  1511 LGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDA 1575

  Fly  1772 IENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLMRGILRAHLSDAQSAAADIKPMRFNGPW 1836
            :.||:.|.:.|||||||||.||||||||.:.||||..|:..|..||||.| ..|:..|   ...|
  Rat  1576 VVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDHLSDLQ-GRAEGDP---RASW 1636

  Fly  1837 EIFDAKEYGYDIFSNVPNTACDMSRALRKERKEAKQQRMSSNSDRTSNLNGLLAEKKEEQKPEDL 1901
            :.     |...:.......|||:..
  Rat  1637 DF-----YSSSVLEKKDGFACDLLH---------------------------------------- 1656

  Fly  1902 DQDRVTTTIKQNGETSATKTGSATTTTATTMVKLELGTDEDSNNNKNNEELNANVENNLVTSVVN 1966
                             ...|||           |.|.|.:.
  Rat  1657 -----------------NPPGSA-----------EQGDDSEQ----------------------- 1670

  Fly  1967 VKNEVKKEVEAEAETEAETETNAKANTNSSTRLDEDQTDIETMDSELNGDIFEFEEADVPLPPLY 2031
                                                             |.|.||.:|.||.|.|
  Rat  1671 -------------------------------------------------DDFMFELSDKPLLPCY 1686

  Fly  2032 LLK---DEGSDKWVLLNDLCNLLKVKSKDTLLNKLCPNNSNALASSQKHL-LREFKIDDFLEKAT 2092
            .|:   ..|...|.|.:|:...||:.|:  :.....|           || :......:|..:..
  Rat  1687 NLQVSVSRGPCNWFLFSDVLKRLKLSSR--IFQARFP-----------HLEITTLPKAEFYRQVA 1738

  Fly  2093 CLQLLCAGEKLNMF-------SSSKVVLIKYNDSVRNLLG 2125
            ..|||...|:....       ||..|.|::|...:..|||
  Rat  1739 SSQLLTPAERPGSLEDRSPPGSSETVELVQYEPELLRLLG 1778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14073	NP_649060.1	PHA03247	<123..554	CDD:223021	113/467 (24%)
		TolA	1068..>1213	CDD:442298	33/195 (17%)
		ANKYR	<1686..1846	CDD:440430	76/159 (48%)
		ANK repeat	1697..1728	CDD:293786	11/30 (37%)
		ANK repeat	1730..1761	CDD:293786	19/30 (63%)
		ANK repeat	1763..1788	CDD:293786	13/24 (54%)
		PUFD_like	2016..2129	CDD:271222	32/120 (27%)
Bcorl1	NP_001178516.1	PHA03247	<201..636	CDD:223021	130/596 (22%)
		ANKYR	<1499..1615	CDD:440430	63/115 (55%)
		ANK repeat	1501..1532	CDD:293786	11/30 (37%)
		ANK repeat	1534..1565	CDD:293786	19/30 (63%)
		ANK repeat	1567..1596	CDD:293786	17/28 (61%)
		PUFD_like_1	1669..1782	CDD:271223	32/194 (16%)