Protein Alignment CG14073 and bcor

DIOPT Version :10

• Sequence 1: NP_649060.1
• Gene: CG14073 / 40046
• FlyBaseID: FBgn0036814
• Length: 2133
• Species: Drosophila melanogaster
• Sequence 2: XP_012811904.1
• Gene: bcor / 100145189
• XenbaseID: XB-GENE-1010841
• Length: 1687
• Species: Xenopus tropicalis
• Alignment Length: 2214
• Identity: 430/2214 - (19%)
• Similarity: 709/2214 - (32%)
• Gaps: 785/2214 - (35%)

  Fly   109 LAEDQRG-------------SRSAIYMSRS--TQPGLPPP----HPHSSAQGS-----------G 143
            |.||..|             |.:|:.|.|:  .|.|:..|    :|.....||           |
 Frog    45 LREDHLGHTLVDAAAVHRIDSLTALTMDRTGLMQEGMRVPSGMVYPSLCGLGSEKVREPSGTIPG 109

  Fly   144 AAGTSGSDPHMQYYTS------NQNLAIKKMSDPHPMWSYKSQAVTTPAPAP------------- 189
            ....|..:|.:||..:      |.::::|:.:..:|:  :|:......||.|
 Frog   110 LGYVSDRNPDLQYKPTAAETMDNSHMSMKQSNGFNPL--FKTPPGLQKAPVPTSESLVMDRSASD 172

  Fly   190 ---GLRQHG---------NPALYPTGSTAYWPPPDEQLHHQQPSRYSYAKPGGPVTGSRPIQGPL 242
               .|..:|         ||.:..| |.|.:|..|      .|::||.          ...:..|
 Frog   173 KQNPLSVNGANYLRIPWMNPYMEST-SPAMYPFID------SPNKYSL----------NMYKAFL 220

  Fly   243 PNSQRY-YSEDIKYSTVPAASKVLTYAPP--------ASSSQPQ---PPPPTSSSSANSSSVRHY 295
            |....| ..:.:.||.|....:...|.||        ||...|.   |||  |::.|..:||...
 Frog   221 PQQSAYSIPQHLAYSPVCPNGERFVYIPPSHYVGPHIASGLAPSIKIPPP--SATPAIPTSVHCL 283

  Fly   296 ELDV-----VNPSNPSNEH--------QQP------------------------SPNYGRKCP-- 321
            |.::     |:|.:..:.|        :||                        .|:....||
 Frog   284 EKNLPWKMGVSPGSAVDSHAYSHLPNSKQPRVTCVKSTTGNISPEPALLLNPSQRPSSRLHCPVQ 348

  Fly   322 ------PHYETP----PEQRSAGATPNSTGTPTSTSHHQSLYIPMPTFSTEKF-QTTVHNAIEKY 375
                  ..::||    |       ||     |||..|.:.|......|:..:. ...||...|..
 Frog   349 QVGDSFSEFQTPFAKIP-------TP-----PTSIVHSKPLCNVSNDFTPLRIPNIKVHKNHEPE 401

  Fly   376 IRETPGPSLEYPRGGVAPVGRTGYYNQQPMKSSKAPPSVPQTATSSYVKMEPEHALAGGLPQPTR 440
            |.:...|                ....:..|.||:|         ..|:.:..|...|
 Frog   402 IAQVQAP----------------LKKNRDRKESKSP---------VLVQKQMPHKDGG------- 434

  Fly   441 SSLYHNPYNVESR--ERDSSPAMATVPAPHGYPTKYGKLIQQQHAASGVGTGSSAPYQSYYHQGT 503
                ..|.::.|:  :.|.|....|..||           ...|.||.|.|...:...:  |:..
 Frog   435 ----EKPLDLSSKFGDADISKVECTENAP-----------SILHLASHVNTMGLSSRDA--HKEA 482

  Fly   504 PSPAAGAVASPTPAPLPPLAEA---PGTIFGPGT-GLNPGIPPHSSQPVPPPANSQQPASSSSSS 564
            .||...:.....|..:...|.:   ||......| |:...:...:.:.|.|    ||.:||....
 Frog   483 ISPPTNSSGIVRPEIISTAASSWVVPGITHTEETNGIIMSLKNKTLERVMP----QQRSSSCPRM 543

  Fly   565 NANFSTLQVYPHGPDICYQPGSQTQAQNQTQNHPNPAKKSPAVTKPNYRALINDMLKRNTASEQE 629
            .::.|.         :|..||. ..|..:      ||..|||   ||..|.:     ||   .::
 Frog   544 GSSESV---------VCSNPGI-VPAMGR------PASASPA---PNANAEV-----RN---PED 581

  Fly   630 LNLQIIKKTLNMEPASSRNHSAPSRVIQQSAAPAAISI--PSAPPPPPPAIHS-------PLDLS 685
            .|..:|::.......|.:|    ||.::.|...:.:.:  .|.||..|..:|.       ||
 Frog   582 CNKSVIQQVPTSVSTSVKN----SRAVKSSVPESTMKVNENSMPPAAPMFVHQSEPFCSPPL--- 639

  Fly   686 MRTVKQTADSTEYKYQRPSTDYKLPQGGLGGGLGLPRFDITPNFSAATRGGAPTSPAPTPVIRQA 750
                  ...|:...||...|            |.|....:        ...||.  .|.||:...
 Frog   640 ------AYPSSFIPYQVSET------------LALSHLHL--------HNKAPV--YPHPVLLSN 676

  Fly   751 VAIQPAPVPPTVPVP---PAVAAPALVIKTVQQMRPSVVETNPFAKRQQQLPPETSIVQVTKPTV 812
            .::.|.|:.|...:|   |..........|:..:.|.:            |||.|  ::::|...
 Frog   677 GSLFPGPMAPKPGIPYSMPTNRDYMTYQDTLGMVHPIL------------LPPTT--IEMSKDGQ 727

  Fly   813 ELMPTPSPSPHNSSNPNYLGKKRHLQEYNQAAAKQA-RLDAESSGSLVSGAPVIAAPTSVVVVAP 876
            |........|....:|    .:..|.:.:.:::|.: .:.|:.:..:..|:..::.|
 Frog   728 ERRSRSHERPRYDDSP----PRSRLLDISDSSSKLSFEIPADKALKVHHGSRHVSKP-------- 780

  Fly   877 VPVIAVNEQALAAKREREMQ---SMSAESSTSAHLVPKMEPRIR-----TKAELKGFTFTPPVLV 933
                    :.|:...||:.:   :::.:..|:...|.|.|..::     |:.|::.
 Frog   781 --------EKLSTNAERDAKCNTNLAVKLKTNDVTVEKPEQGLQNRDLITREEIQR--------- 828

  Fly   934 TSTTNASSTISPPRTPPNQITNHIQIKLEPAPPKATDLGLDDEQHSLGNLMDWGSTCNNLVEQLM 998
            |:..:.|..:|.| |..:.:.::.|                  :..|||   ..:.|:  ..:..
 Frog   829 TNEFHRSFQVSRP-TLESPVFHYRQ------------------ESPLGN---QNADCS--AAEAC 869

  Fly   999 SKVVVPPTLPANNPGIKLELSEDDLPVARILKRQPLAAPSLAGGDAESATTQLTTTTNGISSSLG 1063
            ::.:.||             ..:|:||....:.|..:.|.| |.:..|....:        .|||
 Frog   870 ARFLAPP-------------ESNDVPVGHFSRGQEKSQPFL-GSNGHSDIEMI--------DSLG 912

  Fly  1064 NGSGQK------KLSKVEREKKRQQQEQRIAARLAPKQGQ-SSSSESDTTELHKRNT--ARQKKP 1119
            ..:..:      ||.|.:..|        :..|:|...|. ....:..||||:..::  :|:::.
 Frog   913 RDAADEFETINGKLVKTKSSK--------LTKRIANSAGYVGDRFKCVTTELYADSSQLSREQRA 969

  Fly  1120 LLRKGRTRQR--SPEAASIQQSSDEEQEKVSQRLSRKPRTSSEESKTKATSAKKDVKKEAKTPSN 1182
            |..:|.....  ||.||..        |:...|.|.....:.||...         .|::::..|
 Frog   970 LQIEGLEEDSILSPPAAYC--------ERAMMRFSELEMKAQEEHMP---------SKDSESCKN 1017

  Fly  1183 KTNNSASLTKIKKKTTDSSSLNKAKGDENPKQESQESTSSESDQDDNDNDNDEEEEDQEEDEEEP 1247
            .|........:.|...:.|...:.:|.|       :||....|:
 Frog  1018 VTEWEELKPAVAKPVVEHSGNIQMEGLE-------KSTLVNMDE--------------------- 1054

  Fly  1248 EEEDDDEEQDKKKEKRVGRRPGNTLKKRIAH--KLNTMTRSKHRKELELQLANSKVLRNDKIIRN 1310
                            :.:.|.....||..|  ::|              |....||..|...:.
 Frog  1055 ----------------IAKYPEREYLKRDCHFERMN--------------LYEEAVLPTDNFSQR 1089

  Fly  1311 STTKIKRKYVRKVVDSKKEMMVTRLRNKRGMNSDLGALNGRNSKLKGSKVGNSPGKPKTSPQQQL 1375
            ....||||:..   |.:.|..:..|..:..:..:..|...:.....|:.:.:...|
 Frog  1090 HCLSIKRKHPE---DIQPEEFLHSLTTEEALREETQAKRKKIDDYCGNDLVDCSSK--------- 1142

  Fly  1376 YLEEYRYKLALKIPHSLISINKLN--KVASSLPDLERRDLSQELACFKRNRPKTKAASKQDFTPK 1438
                     ||...||    |::.  ||...|..|.                           ||
 Frog  1143 ---------ALAESHS----NEVTNLKVCIELTGLH---------------------------PK 1167

  Fly  1439 SIIDVLHLRVTNGSTAGTQRKISVSAPASTNLQIHSETSQ-----TSASTSLYEQSQQDNPTENQ 1498
            ....:.|||...........:|.|.:.....|:...|...     .|..||..|..:.|.|.|:.
 Frog  1168 KQRHLQHLRELGQQCRRDSSEIRVVSETENKLRPWEEEQSIKKKPESKCTSGLESIKTDIPEEDT 1232

  Fly  1499 SLDDMSKRHFSIFDTKVLQSKTRTETKLQKHREIIREIFVGPERPASAPPECVQEAD--GGDAIS 1561
            |:    ..|...|.:....||.:.:|    |..::..:....::........||.||  ||
 Frog  1233 SV----PLHPKGFTSGCPSSKQQNQT----HSTLVPRLGSKQQKIRDGRKSNVQNADEEGG---- 1285

  Fly  1562 YQKYEEFLQQMNSIASANDSKLARRSLMEDKSVTAPQCPHKRKYRCRKGSSGFDYIRKKKRPAPT 1626
                                 |...||:||  .|..:.| ..|.:|           |.|..||.
 Frog  1286 ---------------------LQDTSLLED--YTDCEKP-SGKRQC-----------KTKHLAPQ 1315

  Fly  1627 QTQNHTQNQSQSQVSSQ--ITQHILEHNQSAADERLEDTDSTIAGSSHLP------PKVKTEMDV 1683
            :.:....:.|....:.:  :.:...:|.:.::|:....|...:|.:...|      |....|...
 Frog  1316 ERRRKKLSVSGDDSTDEKVVLRGHKKHAEGSSDDSPVKTQEQMAPAIQTPSLSLPLPNTVQEATP 1380

  Fly  1684 CR----EIQKWVLNKGVGQSTMHKAARQGLIDVVVYCLDRMNMNPDQKDNAGYTPLHEACTQGWL 1744
            .|    |.::.::||..|::.:.:|||.|..:||:|||:..:.:.:.:|||||..|||||.:|||
 Frog  1381 SRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLESKSCDVNHRDNAGYCALHEACARGWL 1445

  Fly  1745 EIARILLQYGANHSEAAQSGIRPLHGAIENDHEEVVRLLLSYGADPLLATYSGQTPLMLASSKLM 1809
            .|.|.||::||:.:.:||.|.||:|.|:||||.|:|||||||||||.||||||:|...:..|:.|
 Frog  1446 SIVRHLLEHGADVNCSAQDGTRPIHDAVENDHLEIVRLLLSYGADPTLATYSGRTIAKMTHSEAM 1510

  Fly  1810 RGILRAHLSDAQSAAADIKPMRFNGPWEIFDA------KEYGYDIFSNVPNTACDMSRALRKERK 1868
            ...|..:|:|.|..:.|...:    .|:.:.:      :|.|:||.:|.|
 Frog  1511 ETFLTEYLTDLQGRSCDDPGL----SWDFYGSSVCDLKEESGFDILANPP--------------- 1556

  Fly  1869 EAKQQRMSSNSDRTSNLNGLLAEKKEEQKPEDLDQDRVTTTIKQNGETSATKTGSATTTTATTMV 1933
                                                                             
 Frog  1557 ----------------------------------------------------------------- 1556

  Fly  1934 KLELGTDEDSNNNKNNEELNANVENNLVTSVVNVKNEVKKEVEAEAETEAETETNAKANTNSSTR 1998
                |.||:.:...
 Frog  1557 ----GPDEEDDGYM--------------------------------------------------- 1566

  Fly  1999 LDEDQTDIETMDSELNGDIFEFEEADVPLPPLYLLK---DEGSDKWVLLNDLCNLLKVKSKDTLL 2060
                             |.||||.:|.||.|.|.::   .:|...|:||:::...||:
 Frog  1567 -----------------DAFEFEFSDSPLLPCYNIQVSLSQGPRNWMLLSEVTKRLKM------- 1607

  Fly  2061 NKLCPNNSNALASSQKHL-LREFKIDDFLEKATCLQLLCAGEKLNMFSSSK---VVLIKYNDSVR 2121
                  :|....:...|| :......:|.::.:..||..:.|.|..||...   |.|:::.:.::
 Frog  1608 ------SSQTFTAENPHLEIVTITEAEFYKQVSLSQLFSSPEGLEGFSPDSREMVDLVEFTNELQ 1666

  Fly  2122 NLLG 2125
            .|||
 Frog  1667 TLLG 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14073	NP_649060.1	PHA03247	<123..554	CDD:223021	105/546 (19%)
		TolA	1068..>1213	CDD:442298	30/155 (19%)
		ANKYR	<1686..1846	CDD:440430	71/165 (43%)
		ANK repeat	1697..1728	CDD:293786	10/30 (33%)
		ANK repeat	1730..1761	CDD:293786	17/30 (57%)
		ANK repeat	1763..1788	CDD:293786	17/24 (71%)
		PUFD_like	2016..2129	CDD:271222	31/117 (26%)
bcor	XP_012811904.1	BCOR	1163..1353	CDD:434953	46/263 (17%)
		ANKYR	<1396..1524	CDD:440430	65/127 (51%)
		ANK repeat	1398..1429	CDD:293786	10/30 (33%)
		ANK repeat	1431..1462	CDD:293786	17/30 (57%)
		ANK repeat	1464..1493	CDD:293786	21/28 (75%)
		PUFD	1566..1679	CDD:465171	31/186 (17%)