Protein Alignment ftz-f1 and Nr1i2

DIOPT Version :10

• Sequence 1: NP_524143.2
• Gene: ftz-f1 / 40045
• FlyBaseID: FBgn0001078
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_443212.1
• Gene: Nr1i2 / 84385
• RGDID: 69057
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 109/557 - (19%)
• Similarity: 190/557 - (34%)
• Gaps: 196/557 - (35%)

  Fly   506 ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAER-SCHIDKTQRKRCPYCRFQKCL 569
            ::|.|||||.:|||:.::|||.|||||:|.::......|...: :|.|.:..|::|..||.:|||
  Rat    36 QICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCL 100

  Fly   570 EVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQ--------VMRQRQLALQALRNSMGPDIKPT 626
            |.|||.|.:.:|.....|.   .:.||.:..|::        :..::|..:|.|.::..... .|
  Rat   101 ESGMKKEMIMSDAAVEQRR---ALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTF-DT 161

  Fly   627 PISPGYQQAYPNMNIKQEIQIPQV--SSLTQSP--------DSSPSPIAIALGQVNASTGGVIAT 681
            ..|.......|.: ...:.::|:|  :||.:.|        ||.|..|::.|
  Rat   162 TFSHFKDFRLPAV-FHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQL------------- 212

  Fly   682 PMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLH 746
                                          .|.:
  Rat   213 ------------------------------RGED------------------------------- 216

  Fly   747 RNGGNGNSSCHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQT 811
                           ||:.|           ..|.|.:|.    ..:.|::..
  Rat   217 ---------------GSIWN-----------YQPPSKSDG----KEIIPLLPH------------ 239

  Fly   812 QLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVL 876
                |....||      :|:           ..:::|:....|::|.::||:.||:.:..:|.:|
  Rat   240 ----LADVSTY------MFK-----------GVINFAKVISHFRELPIEDQISLLKGATFEMCIL 283

  Fly   877 DHLHHRIHNGLPDET-------------QLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKF 928
                 |.:.....||             ..|.|  |..:.|         |...:....|:.|:.
  Rat   284 -----RFNTMFDTETGTWECGRLAYCFEDPNGG--FQKLLL---------DPLMKFHCMLKKLQL 332

  Fly   929 DMGDYVCMKFLILLNPSVRGIVNRKTVSEGHDNVQAALLDYTLTC---YPSVNDKFRGLVNILPE 990
            ...:||.|:.:.|.:|...|:|.|..|.:..:.....|..| :.|   ||:....|..::.:|.|
  Rat   333 REEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAY-IECSRPYPAHRFLFLKIMAVLTE 396

  Fly   991 IHAMAVRGEDHLYTKHCAGSAPTQTLLMEMLHAKRKG 1027
            :.::..:....|.  ....:.|..|.||:.|.:...|
  Rat   397 LRSINAQQTQQLL--RIQDTHPFATPLMQELFSSTDG 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	37/92 (40%)
		NR_LBD_Ftz-F1_like	794..1024	CDD:132742	47/245 (19%)
Nr1i2	NP_443212.1	NR_DBD_like	37..124	CDD:413390	35/89 (39%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		4/25 (16%)
		Hinge	105..142		7/39 (18%)
		NR_LBD	140..425	CDD:472173	69/442 (16%)