DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ftz-f1 and nr5a1a

DIOPT Version :9

Sequence 1:	NP_524143.2	Gene:	ftz-f1 / 40045	FlyBaseID:	FBgn0001078	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_571869.1	Gene:	nr5a1a / 83916	ZFINID:	ZDB-GENE-010504-1	Length:	454	Species:	Danio rerio

Alignment Length:	536	Identity:	205/536 - (38%)
Similarity:	276/536 - (51%)	Gaps:	96/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 IDFK--HLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRC 560
            :||:  ...||||||||||||||||||||||||||||||||||.|.|||...:.|.|||||||||
Zfish     1 MDFRADEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCTQNQDCGIDKTQRKRC 65

  Fly   561 PYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKP 625
            |:|||||||.|||:|||||||||||||||||||||||||     ::|::.||  :|.|
Zfish    66 PFCRFQKCLSVGMRLEAVRADRMRGGRNKFGPMYKRDRA-----LKQQKRAL--IRAS------- 116

  Fly   626 TPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGTGGS 690
                 |::.......:..:.:...|.  .|||...|.|   |||....:.|...|...
Zfish   117 -----GFKLEANGTLLSGQTEFSSVG--LQSPYDCPPP---ALGVALQNYGSFPAQYQ------- 164

  Fly   691 GGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNGNSS 755
                ...||...:..:....:..::..||                 .|.:..||
Zfish   165 ----YTAPSLPKSIKAEYPDAYPSSPDST-----------------LGYSYADG----------- 197

  Fly   756 CHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQT--QLFALLQ 818
                             |..:..|......||      .|::.| :||.|..|.|.  ::.|.|.
Zfish   198 -----------------CLSASPHSVPINPAL------PPLVLE-LQSCDPDEEQVRGKICAYLH 238

  Fly   819 KQTYNQVEVDL---FELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLH 880
            ::...:.:::.   ..|:|.:.||.|||.|:|||:.||||:|||.|||:||.:.||::|:|||:.
Zfish   239 QEQSGRGKLEKSRPSSLLCVMADQTLFSIVEWARSCVFFKELKVGDQMRLLHNCWSELLLLDHIC 303

  Fly   881 HRIHNGLPDETQLNNGQVFNLMSLGLLGVP--QLGDYFNELQNKLQDLKFDMGDYVCMKFLILLN 943
            .::|:|......|..||...|.::...|.|  .:.:...:|..:||.|:.|..:..|:|||||.|
Zfish   304 RQVHHGRDGSLLLITGQEVELSAVLDAGPPLSSMVERGQDLSRRLQLLQVDSREMACLKFLILFN 368

  Fly   944 PSVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLYTKHCA 1008
            |:|:.:.|.:.|....:.|..|||:|||..||...::|..|:..|||:.:::...||.|..||..
Zfish   369 PNVKLLENPQFVESVQEQVNGALLEYTLFSYPQCVERFSQLILRLPELRSLSAEAEDFLCYKHLC 433

  Fly  1009 GSAPTQTLLMEMLHAK 1024
            |..|...||:||||||
Zfish   434 GEVPCNNLLIEMLHAK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	80/91 (88%)
ftz-f1	NP_524143.2	NR_LBD_Ftz-F1_like	794..1024	CDD:132742	89/236 (38%)
nr5a1a	NP_571869.1	NR_DBD_Lrh-1_like	13..105	CDD:143541	81/96 (84%)
nr5a1a	NP_571869.1	NR_LBD_Ftz-F1_like	212..449	CDD:132742	90/243 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592412
Domainoid	1	1.000	148	1.000	Domainoid score	I4406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2070
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	1	1.000	-	-		FOG0002223
OrthoInspector	1	1.000	-	-		otm25452
orthoMCL	1	0.900	-	-		OOG6_105772
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900