DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ftz-f1 and Nr5a2

DIOPT Version :9

Sequence 1:	NP_524143.2	Gene:	ftz-f1 / 40045	FlyBaseID:	FBgn0001078	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_109601.1	Gene:	Nr5a2 / 26424	MGIID:	1346834	Length:	560	Species:	Mus musculus

Alignment Length:	567	Identity:	214/567 - (37%)
Similarity:	297/567 - (52%)	Gaps:	132/567 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 EVIDFKHL-------FEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHID 553
            :|..||.:       .||||||||||||||||||||||||||||||||||:|.|||:..::|.||
Mouse    88 QVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQID 152

  Fly   554 KTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQ---VMRQRQLALQAL 615
            ||||||||||||:||::|||||||||||||||||||||||||||||.|.|   ::|...|.|:|:
Mouse   153 KTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAM 217

  Fly   616 RNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSP---SPIAIALGQVNASTGG 677
              |......|:.::...|..:   :..:.:.:..|:......|.||   |||::.:
Mouse   218 --SQVIQAMPSDLTSAIQNIH---SASKGLPLSHVALPPTDYDRSPFVTSPISMTM--------- 268

  Fly   678 VIATPMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSN 742
                |.::...|....| :.||........:..|:...:..                   |.:..
Mouse   269 ----PPHSSLHGYQPYG-HFPSRAIKSEYPDPYSSSPESMM-------------------GYSYM 309

  Fly   743 DGLHRNGGNGNSSCHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDR 807
            ||...|.                              |:|....::|.|:..|         |:.
Mouse   310 DGYQTNS------------------------------PASIPHLILELLKCEP---------DEP 335

  Fly   808 EWQTQLFALLQKQTYN---QVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHS 869
            :.|.::.|.||::..|   |.::..|.|:||:.||.|||.|:|||:::||::|||||||||||:.
Mouse   336 QVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNC 400

  Fly   870 WSDMLVLDHLHHRIHNGLPDETQLNNGQVF---------------------NLMSLGLLGVPQLG 913
            ||::|:|||::.::.:|       ..|.:|                     ||:||.
Mouse   401 WSELLILDHIYRQVAHG-------KEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLA-------- 450

  Fly   914 DYFNELQNKLQDLKFDMGDYVCMKFLILLNPSVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVN 978
               .||..:|:.|:||..::||:|||:|.:..|:.:.|.:.|....:.|.|||||||:..||...
Mouse   451 ---QELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQT 512

  Fly   979 DKFRGLVNILPEIHAMAVRGEDHLYTKHCAGSAPTQTLLMEMLHAKR 1025
            :||..|:..||||.|::.:.||:||.||..|..|...||:|||||||
Mouse   513 EKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKR 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	80/91 (88%)
ftz-f1	NP_524143.2	NR_LBD_Ftz-F1_like	794..1024	CDD:132742	94/253 (37%)
Nr5a2	NP_109601.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..55
		NR_DBD_Lrh-1_like	107..199	CDD:143541	80/91 (88%)
		FTZ-F1 box	176..205		25/28 (89%)
		NR_LBD_Lrh-1	320..560	CDD:132754	99/267 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847182
Domainoid	1	1.000	144	1.000	Domainoid score	I4586
eggNOG	1	0.900	-	-		E1_KOG4218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2064
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002223
OrthoInspector	1	1.000	-	-		otm43073
orthoMCL	1	0.900	-	-		OOG6_105772
Panther	1	1.100	-	-	LDO	PTHR24086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2678
SonicParanoid	1	1.000	-	-		X1468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780