DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ftz-f1 and NR5A2

DIOPT Version :9

Sequence 1:	NP_524143.2	Gene:	ftz-f1 / 40045	FlyBaseID:	FBgn0001078	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_995582.1	Gene:	NR5A2 / 2494	HGNCID:	7984	Length:	541	Species:	Homo sapiens

Alignment Length:	643	Identity:	236/643 - (36%)
Similarity:	322/643 - (50%)	Gaps:	177/643 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 MSSGS-VGNGSGGAGNG----GAGGNSGPGNPMG----------------GTSATPGHGG----- 495
            |||.| .|:......:|    |||.....|:|:.                |.:.:.|..|
Human     1 MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPEN 65

  Fly   496 -EVIDFKHL-------FEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHI 552
             :|..||.:       .||||||||||||||||||||||||||||||||||.|.|||:..::|.|
Human    66 MQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQI 130

  Fly   553 DKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQ---VMRQRQLALQA 614
            |||||||||||||||||.|||||||||||||||||||||||||||||.|.|   ::|...|.|:|
Human   131 DKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEA 195

  Fly   615 LRNSMGPDIKPTPISPGYQQAYP-NMNIKQEIQ--------IPQVSSLTQSP---DSSP---SPI 664
            :...:              ||.| ::.|...||        :| ::.....|   |.||   |||
Human   196 MSQVI--------------QAMPSDLTISSAIQNIHSASKGLP-LNHAALPPTDYDRSPFVTSPI 245

  Fly   665 AIALGQVNASTGGVIATPMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGG 729
            ::.:             |.:        |.|.|..:.|:..|.
Human   246 SMTM-------------PPH--------GSLQGYQTYGHFPSR---------------------- 267

  Fly   730 NNAGGGGGGTNSNDGLHRNGGNGNSSCHEAGIG-----SLQNTADSKLCFDSGTHPSSTADALIE 789
                          .:.....:..:|..|:.:|     |.|.::           |:|....::|
Human   268 --------------AIKSEYPDPYTSSPESIMGYSYMDSYQTSS-----------PASIPHLILE 307

  Fly   790 PLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQ---VEVDLFELMCKVLDQNLFSQVDWARNT 851
            .|:..|         |:.:.|.::.|.||::..|:   .::..|.||||:.||.|||.|:|||::
Human   308 LLKCEP---------DEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSS 363

  Fly   852 VFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQ--------------VFNLM 902
            :||::|||||||||||:.||::|:|||::.::.:|......|..||              :.|||
Human   364 IFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLM 428

  Fly   903 SLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPSVRGIVNRKTVSEGHDNVQAALL 967
            |           :..||..||:.|:||..::||:|||:|.:..|:.:.|.:.|....:.|.||||
Human   429 S-----------HAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALL 482

  Fly   968 DYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLYTKHCAGSAPTQTLLMEMLHAKR 1025
            |||:..||...:||..|:..||||.|::::.|::||.||..|..|...||:|||||||
Human   483 DYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	82/91 (90%)
ftz-f1	NP_524143.2	NR_LBD_Ftz-F1_like	794..1024	CDD:132742	95/246 (39%)
NR5A2	NP_995582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		11/33 (33%)
		NR_DBD_Lrh-1_like	86..178	CDD:143541	82/91 (90%)
		FTZ-F1 box	155..184		25/28 (89%)
		NR_LBD_Lrh-1	301..541	CDD:132754	100/260 (38%)
		Phosphatidylglycerol phosphate binding. /evidence=ECO:0000269\|PubMed:15897460	421..424		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156772
Domainoid	1	1.000	148	1.000	Domainoid score	I4480
eggNOG	1	0.900	-	-		E1_KOG4218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2074
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278717at33208
OrthoFinder	1	1.000	-	-		FOG0002223
OrthoInspector	1	1.000	-	-		otm41002
orthoMCL	1	0.900	-	-		OOG6_105772
Panther	1	1.100	-	-	LDO	PTHR24086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2678
SonicParanoid	1	1.000	-	-		X1468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790