Protein Alignment ftz-f1 and Nr1i2

DIOPT Version :10

• Sequence 1: NP_524143.2
• Gene: ftz-f1 / 40045
• FlyBaseID: FBgn0001078
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_035066.1
• Gene: Nr1i2 / 18171
• MGIID: 1337040
• Length: 431
• Species: Mus musculus
• Alignment Length: 551
• Identity: 116/551 - (21%)
• Similarity: 189/551 - (34%)
• Gaps: 184/551 - (33%)

  Fly   506 ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAER-SCHIDKTQRKRCPYCRFQKCL 569
            ::|.|||||.:|||:.::|||.|||||:|.::......|...: :|.|.:..|::|..||.:|||
Mouse    36 QICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCL 100

  Fly   570 EVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKPTPISPGY-- 632
            |.|||.|.:.:|.....|.   .:.||.:..|::.                    |.|...|.
Mouse   101 ESGMKKEMIMSDAAVEQRR---ALIKRKKREKIEA--------------------PPPGGQGLTE 142

  Fly   633 -QQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGTGGSGGGGLN 696
             |||     :.||:...|:    |:.|:
Mouse   143 EQQA-----LIQELMDAQM----QTFDT------------------------------------- 161

  Fly   697 GPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNGNSSCHEAGI 761
                                                      |.|:....|.....:|.|
Mouse   162 ------------------------------------------TFSHFKDFRLPAVFHSGC----- 179

  Fly   762 GSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSI---------DDREWQTQLFALL 817
             .|.....:.|..|..|......|.:  |:::|..:|....||         |.:|....|..|.
Mouse   180 -ELPEFLQASLLEDPATWSQIMKDRV--PMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLLPHLA 241

  Fly   818 QKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHR 882
            ...||      :|:           ..:::|:...:|:||.::||:.||:.:..:|.:|     |
Mouse   242 DVSTY------MFK-----------GVINFAKVISYFRDLPIEDQISLLKGATFEMCIL-----R 284

  Fly   883 IHNGLPDET-------------QLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYV 934
            .:.....||             ..|.|  |..:.|         |...:....|:.|:....:||
Mouse   285 FNTMFDTETGTWECGRLAYCFEDPNGG--FQKLLL---------DPLMKFHCMLKKLQLHKEEYV 338

  Fly   935 CMKFLILLNPSVRGIVNRKTVSEGHDNVQAALLDYTLTC---YPSVNDKFRGLVNILPEIHAMAV 996
            .|:.:.|.:|...|:|.|..|.:..:.....|..| :.|   ||:....|..::.:|.|:.::..
Mouse   339 LMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAY-IECSRPYPAHRFLFLKIMAVLTELRSINA 402

  Fly   997 RGEDHLYTKHCAGSAPTQTLLMEMLHAKRKG 1027
            :....|.  ....|.|..|.||:.|.:...|
Mouse   403 QQTQQLL--RIQDSHPFATPLMQELFSSTDG 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	37/92 (40%)
		NR_LBD_Ftz-F1_like	794..1024	CDD:132742	55/254 (22%)
Nr1i2	NP_035066.1	NR_DBD_like	37..124	CDD:413390	35/89 (39%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		4/25 (16%)
		Hinge	105..142		10/59 (17%)
		NR_LBD	140..425	CDD:472173	73/416 (18%)