DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ftz-f1 and nhr-3

DIOPT Version :9

Sequence 1:	NP_524143.2	Gene:	ftz-f1 / 40045	FlyBaseID:	FBgn0001078	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_510423.1	Gene:	nhr-3 / 181551	WormBaseID:	WBGene00003602	Length:	463	Species:	Caenorhabditis elegans

Alignment Length:	242	Identity:	79/242 - (32%)
Similarity:	108/242 - (44%)	Gaps:	26/242 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 PMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAE 547
            |..|..:..|..|  ||.:.  ..:|.||.|:.||.|||::.|..|||||:|||:..|.|.|...
Worm    32 PELGEYSPSGENG--IDGEE--STICSVCCDEASGRHYGVVACFGCKGFFRRTVRAGKNYVCRYS 92

  Fly   548 RSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLAL 612
            :.|.|||..|..|..|||||||||||:.:|:|.||.:.||.|..........:|:.|  ...|..
Worm    93 KKCRIDKAGRNVCRSCRFQKCLEVGMEPDAIRPDRDKTGRQKNPRRNTEGSIKKVSV--GSILGD 155

  Fly   613 QALRNSMGPDIKPTPISPGYQQAYPNMNIKQE-IQIPQVSSLTQSPDSSPSPIAIALGQVNASTG 676
            ....|....|......||..:.....|:::.. |....:::||:..:     |.|.| |.|..|.
Worm   156 LPCLNKFKDDSDDAATSPSSRADSAPMDLRPSFIDESVLTTLTEIEN-----IVIQL-QDNFETN 214

  Fly   677 GVIATPMNAGTGGSGGGGLNGPSSVG-----NGNSSNGSSNGNNNSS 718
            .....||        |..:..||.:.     |.|.:.|.::.|..||
Worm   215 QQSLPPM--------GEAITKPSLIAARTLLNFNGAKGVADANCVSS 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ftz-f1	NP_524143.2	NR_DBD_Lrh-1_like	508..600	CDD:143541	45/91 (49%)
ftz-f1	NP_524143.2	NR_LBD_Ftz-F1_like	794..1024	CDD:132742
nhr-3	NP_510423.1	NR_DBD_HNF4A	53..128	CDD:143518	41/74 (55%)
nhr-3	NP_510423.1	NR_LBD	249..432	CDD:132726	3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5899
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960