DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg3 and Atg3

DIOPT Version :9

Sequence 1:	NP_649059.1	Gene:	Atg3 / 40044	FlyBaseID:	FBgn0036813	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_080678.1	Gene:	Atg3 / 67841	MGIID:	1915091	Length:	314	Species:	Mus musculus

Alignment Length:	331	Identity:	208/331 - (62%)
Similarity:	259/331 - (78%)	Gaps:	19/331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSVLNTVKGTALNVAEYLTPVLKESKFRETGVLTPEEFVAAGDHLVHHCPTWQWAAGDETKTKP 65
            ||:|:|||||.||.||||||||||||||:||||:||||||||||||||||||||||.|:|.|.|.
Mouse     1 MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKA 65

  Fly    66 YLPKDKQFLITRNVPCYRRCKQMEYVGE-ETLVEEESGDGGWVETHQLNDDGTTQLEDKICELTM 129
            |||.|||||:|:|||||:|||||||..| |.::||:.||||||:|:  ::.|.|.:.:.:.|:|:
Mouse    66 YLPTDKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTY--HNTGITGITEAVKEITL 128

  Fly   130 EETKEEMHTPDSDKSAPGAGGQAEDEDDDEAIDMDDFEESGMLELVDPAVATTTRKPEPEAKASP 194
             |:|:.:...|.....    .:.::||:.||.||:::||||:|| .|.|...|.:         .
Mouse   129 -ESKDSIKLQDCSALC----DEEDEEDEGEAADMEEYEESGLLE-TDEATLDTRK---------I 178

  Fly   195 VAAASGDAEASG-DSVLHTRTYDLHISYDKYYQTPRLWVVGYDEQRKPLTVEQMYEDVSQDHAKK 258
            |.|....|:|.| |::|.||||||:|:|||||||||||:.||||||:|||||.||||:||||.||
Mouse   179 VEACKAKADAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKK 243

  Fly   259 TVTMESHPHLPGPNMASVHPCRHADIMKKIIQTVEEGGGQLGVHLYLIIFLKFVQTVIPTIEYDF 323
            |||:|:|||||.|.|.||||||||::|||||:||.||||:||||:||:|||||||.||||||||:
Mouse   244 TVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDY 308

  Fly   324 TQNFNM 329
            |::|.|
Mouse   309 TRHFTM 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg3	NP_649059.1	Autophagy_N	8..135	CDD:281916	87/127 (69%)
		Autophagy_act_C	219..280	CDD:281917	48/60 (80%)
		Autophagy_C	301..325	CDD:287367	19/23 (83%)
Atg3	NP_080678.1	Autophagy_N	8..133	CDD:281916	86/125 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..165		6/21 (29%)
		Autophagy_act_C	204..265	CDD:281917	47/61 (77%)
		Autophagy_C	286..309	CDD:287367	17/22 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849642
Domainoid	1	1.000	190	1.000	Domainoid score	I3281
eggNOG	1	0.900	-	-		E1_KOG2981
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6836
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1726
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53787
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004752
OrthoInspector	1	1.000	-	-		oto93002
orthoMCL	1	0.900	-	-		OOG6_102211
Panther	1	1.100	-	-	LDO	PTHR12866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R108
SonicParanoid	1	1.000	-	-		X3344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790