Protein Alignment Atg3 and ATG3

DIOPT Version :10

• Sequence 1: NP_649059.1
• Gene: Atg3 / 40044
• FlyBaseID: FBgn0036813
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_071933.2
• Gene: ATG3 / 64422
• HGNCID: 20962
• Length: 314
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 208/331 - (62%)
• Similarity: 256/331 - (77%)
• Gaps: 19/331 - (5%)

  Fly     1 MQSVLNTVKGTALNVAEYLTPVLKESKFRETGVLTPEEFVAAGDHLVHHCPTWQWAAGDETKTKP 65
            ||:|:|||||.||.||||||||||||||:||||:||||||||||||||||||||||.|:|.|.|.
Human     1 MQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKA 65

  Fly    66 YLPKDKQFLITRNVPCYRRCKQMEYVGE-ETLVEEESGDGGWVETHQLNDDGTTQLEDKICELTM 129
            |||..||||:|:|||||:|||||||..| |.::||:.||||||:|:  ::.|.|.:.:.:.|:|:
Human    66 YLPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTY--HNTGITGITEAVKEITL 128

  Fly   130 EETKEEMHTPDSDKSAPGAGGQAEDEDDDEAIDMDDFEESGMLELVDPAVATTTRKPEPEAKASP 194
             |.|:.:...|......    :.||||:.||.||:::||||:|| .|.|...|.:         .
Human   129 -ENKDNIRLQDCSALCE----EEEDEDEGEAADMEEYEESGLLE-TDEATLDTRK---------I 178

  Fly   195 VAAASGDAEASG-DSVLHTRTYDLHISYDKYYQTPRLWVVGYDEQRKPLTVEQMYEDVSQDHAKK 258
            |.|.....:|.| |::|.||||||:|:|||||||||||:.||||||:|||||.||||:||||.||
Human   179 VEACKAKTDAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEQRQPLTVEHMYEDISQDHVKK 243

  Fly   259 TVTMESHPHLPGPNMASVHPCRHADIMKKIIQTVEEGGGQLGVHLYLIIFLKFVQTVIPTIEYDF 323
            |||:|:|||||.|.|.||||||||::|||||:||.||||:||||:||:|||||||.||||||||:
Human   244 TVTIENHPHLPPPPMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIEYDY 308

  Fly   324 TQNFNM 329
            |::|.|
Human   309 TRHFTM 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg3	NP_649059.1	Autophagy_act_C	<210..323	CDD:461120	90/112 (80%)
ATG3	NP_071933.2	Membrane-curvature-sensing motif. /evidence=ECO:0000250|UniProtKB:Q9CPX6	4..19		11/14 (79%)
		Increases ATG3 translation efficiency by the ribomome assisted of EIF5A. /evidence=ECO:0000250|UniProtKB:Q9CPX6	101..103		0/1 (0%)
		LIR motif. /evidence=ECO:0000269|PubMed:37252361, ECO:0007744|PDB:8AFI	104..110		5/5 (100%)
		Interaction with ATG12. /evidence=ECO:0000269|PubMed:24191030	140..170		14/34 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..163		9/23 (39%)
		Autophagy_act_C	159..308	CDD:461120	104/158 (66%)
		Caspase cleavage motif LETD. /evidence=ECO:0000269|PubMed:22644571	166..169		2/3 (67%)