DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg3 and atg3

DIOPT Version :9

Sequence 1:	NP_649059.1	Gene:	Atg3 / 40044	FlyBaseID:	FBgn0036813	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_956316.1	Gene:	atg3 / 336632	ZFINID:	ZDB-GENE-030131-8576	Length:	317	Species:	Danio rerio

Alignment Length:	334	Identity:	208/334 - (62%)
Similarity:	263/334 - (78%)	Gaps:	22/334 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSVLNTVKGTALNVAEYLTPVLKESKFRETGVLTPEEFVAAGDHLVHHCPTWQWAAGDETKTKP 65
            ||:|:|:||||||.|||:||||||||||:||||:|||||||||||||||||||:||:|:|.|.||
Zfish     1 MQNVINSVKGTALGVAEFLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWKWASGEEAKVKP 65

  Fly    66 YLPKDKQFLITRNVPCYRRCKQMEYVGE-ETLVEEESGDGGWVETHQLNDDGTTQLEDKICELTM 129
            |||.|||||:|||||||:|||||||..| |.::||:.||||||:|  .::.|.|.:.:.:.|:::
Zfish    66 YLPNDKQFLLTRNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDT--FHNSGVTGVTEAVREISL 128

  Fly   130 EETKEEMHTPDSDKSAPGAGGQAEDEDDD---EAIDMDDFEESGMLELVDPAVATTTRKPEPEAK 191
             :.|:.|:.    ....||.|.:.|:|||   ||.||:::||||:||..|..:.|:......:.|
Zfish   129 -DNKDNMNM----NVKTGACGNSGDDDDDEEGEAADMEEYEESGLLETDDATLDTSKMADLSKTK 188

  Fly   192 ASPVAAASGDAEASG-DSVLHTRTYDLHISYDKYYQTPRLWVVGYDEQRKPLTVEQMYEDVSQDH 255
                      |||.| |::|.||||||:|:|||||||||||:.||||.|:||||:|||||:||||
Zfish   189 ----------AEAGGEDAILQTRTYDLYITYDKYYQTPRLWLFGYDEDRQPLTVDQMYEDISQDH 243

  Fly   256 AKKTVTMESHPHLPGPNMASVHPCRHADIMKKIIQTVEEGGGQLGVHLYLIIFLKFVQTVIPTIE 320
            .|||||:|:||:||.|.|.||||||||::|||||:||.||||:||||:||:|||||||.||||||
Zfish   244 VKKTVTIENHPNLPPPAMCSVHPCRHAEVMKKIIETVAEGGGELGVHMYLLIFLKFVQAVIPTIE 308

  Fly   321 YDFTQNFNM 329
            ||:|::|.|
Zfish   309 YDYTRHFTM 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg3	NP_649059.1	Autophagy_N	8..135	CDD:281916	86/127 (68%)
		Autophagy_act_C	219..280	CDD:281917	46/60 (77%)
		Autophagy_C	301..325	CDD:287367	19/23 (83%)
atg3	NP_956316.1	Autophagy_N	8..133	CDD:281916	86/127 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..165		11/27 (41%)
		Autophagy_act_C	207..268	CDD:281917	46/60 (77%)
		Autophagy_C	289..312	CDD:287367	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595397
Domainoid	1	1.000	195	1.000	Domainoid score	I3106
eggNOG	1	0.900	-	-		E1_KOG2981
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6836
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1713
OMA	1	1.010	-	-		QHG53787
OrthoDB	1	1.010	-	-		D1432328at2759
OrthoFinder	1	1.000	-	-		FOG0004752
OrthoInspector	1	1.000	-	-		oto39849
orthoMCL	1	0.900	-	-		OOG6_102211
Panther	1	1.100	-	-	LDO	PTHR12866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R108
SonicParanoid	1	1.000	-	-		X3344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800