DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and MKRN3

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_005655.1	Gene:	MKRN3 / 7681	HGNCID:	7114	Length:	507	Species:	Homo sapiens

Alignment Length:	280	Identity:	90/280 - (32%)
Similarity:	132/280 - (47%)	Gaps:	38/280 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VLPVPSTNSPSSQIEQKGNEAIVPNYKAATAGEQGEAQAGATCTTV-----------AVRPSGVA 68
            |...|.....||:.|:| ..|:....:......:|....|.:|..:           .:.|...|
Human   217 VASAPEAPLQSSETERK-QMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAA 280

  Fly    69 TSADIVKGSSSVSSHVQPSWRSSFA--RSQDKKCGICFETIMEKEG-GDKRFGILPSCNHVFCFQ 130
            ...:.::  :.:.:| :.....|||  |..||.||||.|.:.||.. .|:|||||.:|||.||.:
Human   281 QREEHMR--ACIEAH-EKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIR 342

  Fly   131 CICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFKQGQ 195
            ||..||.|.|:..::.::||:|||.|..|.||.|||||:..|.:||..:..||..:.|:||.:|:
Human   343 CIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGR 407

  Fly   196 GVCLFGNKCFYKHSIPNADYVDVGLP--------THALGLPIPSDFSGLGNC--------LILVP 244
            |.|.||:.|||||..|.....:...|        .|.|..|:.   .|.||.        |:::.
Human   408 GNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVR---MGEGNMLYKSIKKELVVLR 469

  Fly   245 FPNMFFDDF-SNSDDYDFSD 263
            ..::.|..| |..|:..||:
Human   470 LASLLFKRFLSLRDELPFSE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	26/54 (48%)
MKRN3	NP_005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		DNA_pol3_gamma3	<33..232	CDD:331207	4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..89
		ZnF_C3H1	95..121	CDD:214632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..149
		PHA02929	<252..400	CDD:331986	54/150 (36%)
		Makorin-type Cys-His	266..293		2/28 (7%)
		RING-HC_MKRN1_3	308..368	CDD:319644	31/59 (53%)
		RING-HC finger (C3HC4-type)	311..364	CDD:319644	26/52 (50%)
		MKRN1_C	439..505	CDD:318109	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	0.172	Domainoid score	I8156
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3270
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830