DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and Mkrn2

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_075779.2	Gene:	Mkrn2 / 67027	MGIID:	1914277	Length:	416	Species:	Mus musculus

Alignment Length:	227	Identity:	78/227 - (34%)
Similarity:	113/227 - (49%)	Gaps:	25/227 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VDTGVLPVPSTNSPSSQIEQKGNEAIVPNYKAATAGEQGEAQAGATCTTV-----------AVRP 64
            :.||:..:.:::|.|       ||..:..|.||     ||.:.|..|..:           .:.|
Mouse   151 IRTGLDDLEASSSYS-------NEPQLCPYAAA-----GECRFGDACVYLHGDMCEICRLQVLHP 203

  Fly    65 SGVATSADIVKGSSSVSSHVQPSWRSSFARSQDKKCGICFETIMEK-EGGDKRFGILPSCNHVFC 128
            ..........|...|...| :.....:|..||||.|.||.|.|:|| ...::|||||.:|:|.:|
Mouse   204 FDPEQRKAHEKMCMSTFEH-EMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCSHTYC 267

  Fly   129 FQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFKQ 193
            ..||..||.|.|:...:.::||||||.|.||.||.:|||::..|::||......|..:.||||:|
Mouse   268 LSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQ 332

  Fly   194 GQGVCLFGNKCFYKHSIPNADYVDVGLPTHAL 225
            |:|.|.||:||.|:|:.|:....:...|...|
Mouse   333 GKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	24/54 (44%)
Mkrn2	NP_075779.2	ZnF_C3H1	2..28	CDD:214632
		ZnF_C3H1	35..55	CDD:214632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..144
		PHA03096	<178..327	CDD:222981	51/149 (34%)
		Makorin-type Cys-His	193..222		3/28 (11%)
		RING	238..292	CDD:238093	24/53 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8159
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.870