DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and mkrn4

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_005167100.1	Gene:	mkrn4 / 559882	ZFINID:	ZDB-GENE-030131-5954	Length:	402	Species:	Danio rerio

Alignment Length:	240	Identity:	79/240 - (32%)
Similarity:	113/240 - (47%)	Gaps:	49/240 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTVASNDQHVDTGVL---------PVP-------------STNSPSSQIEQKGNEAIVPNYKAA 43
            ||.:..|.:.:.||:.         .||             :|:|.||.           || .:
Zfish   131 MSALQRNFERLTTGIAEEEESGVVEDVPLQLGASRTLYQSNATHSSSSH-----------NY-TS 183

  Fly    44 TAGEQGEAQAGATCTTVAVRPSGVATSADIVKG--SSSVSSHVQPSWRSSFARSQDKKCGICFET 106
            |:.....|...||..|||...:.| |.:.:..|  :::|||..|.|  .:|.:|.|..||||.:.
Zfish   184 TSFMAAPAPVEATKITVAEAETQV-TKSPVRSGQVAAAVSSVQQCS--GAFDQSNDVACGICMDK 245

  Fly   107 IMEKE-GGDKRFGILPSCNHVFCFQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKV 170
            |.||. ..::|:||||:|||.||..||.|||....:..:|.:.||:|||.|:|..||..||.:..
Zfish   246 ISEKSTAQERRYGILPNCNHAFCIGCIVTWRKTKDFQEEVIKGCPQCRVKSSFYIPSKHWVCDGE 310

  Fly   171 AKDQLINDHLAAMRARD----CKYFKQGQGVCLFGNKCFYKHSIP 211
            .|..||    |:.:.|.    |.:|.: .|.|.|.::|.|.|.:|
Zfish   311 EKASLI----ASFKERSSKLKCTFFMR-HGCCPFKSECIYSHDMP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	25/54 (46%)
mkrn4	XP_005167100.1	ZnF_C3H1	<53..73	CDD:214632
mkrn4	XP_005167100.1	RING	239..293	CDD:238093	25/53 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580292
Domainoid	1	1.000	79	1.000	Domainoid score	I8592
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.810