DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and mkrn2

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001005447.1	Gene:	mkrn2 / 448038	XenbaseID:	XB-GENE-5879487	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	245	Identity:	78/245 - (31%)
Similarity:	115/245 - (46%)	Gaps:	28/245 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HVDTGVLPVPSTNSPSSQIEQKGN---EAI--------VPN-YKAATA-----GEQGEAQAGATC 57
            |.|..:.|..:.:.|.|::|.|.:   |||        :|: |..|..     .:.|....|.:|
Frog   120 HPDPALRPGCAADPPVSELEAKPHSYLEAICTGLDETPIPSAYPDAPQQLCPFAQAGGCHYGESC 184

  Fly    58 TTVAVRPSGVATSADIVKGSSSVSSHVQPSWRSSFAR----------SQDKKCGICFETIMEKEG 112
            ..:......:.....:.........|.:....::|.|          |:.|.|.||.|.:.:|:.
Frog   185 PYIHGNVCEICGLQVLHPYDQEQRGHHEKLCMANFERDMERAFAFQASEGKVCSICMERVYDKQS 249

  Fly   113 -GDKRFGILPSCNHVFCFQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKVAKDQLI 176
             .::|||||.:|:|.:|..||..||.|.|:...|.::||||||.|.||.|||:|||::..|.:||
Frog   250 PSERRFGILSNCHHTYCLACIRQWRCARQFENPVIKSCPECRVISEFVIPSAYWVEDQSKKFELI 314

  Fly   177 NDHLAAMRARDCKYFKQGQGVCLFGNKCFYKHSIPNADYVDVGLPTHALG 226
            ......|..:.||||.||:|.|.||.||.|.|:.|:....:...|...||
Frog   315 EAFKQGMGKKACKYFDQGRGTCPFGGKCLYLHAYPDGTRAEPEKPRKQLG 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	23/54 (43%)
mkrn2	NP_001005447.1	YTH1	<5..>80	CDD:227416
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..100
		PHA03096	<178..310	CDD:222981	42/131 (32%)
		Makorin-type Cys-His. /evidence=ECO:0000255	192..221		2/28 (7%)
		RING-HC_MKRN2	234..291	CDD:319645	24/56 (43%)
		RING-HC finger (C3HC4-type)	237..290	CDD:319645	22/52 (42%)
		MKRN1_C	360..>412	CDD:374139	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010