DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and Mkrn2

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001008315.1	Gene:	Mkrn2 / 297525	RGDID:	1310618	Length:	417	Species:	Rattus norvegicus

Alignment Length:	267	Identity:	86/267 - (32%)
Similarity:	121/267 - (45%)	Gaps:	51/267 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TVASNDQHVDTGV----LPVPST-------NSPSSQIEQK---------------------GNEA 35
            |:...|::: ||:    .|.|||       |.|.:..|.|                     .||.
  Rat   106 TLVLRDRNL-TGLAEDKTPPPSTVNNPGGCNDPQTSPEMKPHSYLDAIRTGLDDLEASSSYSNEQ 169

  Fly    36 IVPNYKAATAGEQGEAQAGATCTTV-----------AVRPSGVATSADIVKGSSSVSSHVQPSWR 89
            .:..|.||     ||.:.|..|..:           .:.|..........|...|...| :....
  Rat   170 QLCPYAAA-----GECRFGDACVYLHGDMCEICRLQVLHPFDPEQRKAHEKMCMSTFEH-EMEKA 228

  Fly    90 SSFARSQDKKCGICFETIMEK-EGGDKRFGILPSCNHVFCFQCICTWRHATQYAYQVTRACPECR 153
            .:|..||||.|.||.|.|:|| ...::|||||.:|:|.:|..||..||.|.|:...:.::|||||
  Rat   229 FAFQASQDKVCSICMEVILEKASASERRFGILSNCSHTYCLSCIRQWRCAKQFENPIIKSCPECR 293

  Fly   154 VWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFKQGQGVCLFGNKCFYKHSIPNADYVDV 218
            |.|.||.||.:|||::..|::||......|..:.||||:||:|.|.||:||.|:|:.|:....:.
  Rat   294 VISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEP 358

  Fly   219 GLPTHAL 225
            ..|...|
  Rat   359 EKPRKQL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	24/54 (44%)
Mkrn2	NP_001008315.1	zf-CCCH_4	6..27	CDD:407881
		zf_CCCH_4	37..55	CDD:408151
		PHA03096	<179..328	CDD:222981	51/149 (34%)
		RING-HC_MKRN2	236..293	CDD:319645	26/56 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I7980
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880