DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and MKRN2

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_054879.3	Gene:	MKRN2 / 23609	HGNCID:	7113	Length:	416	Species:	Homo sapiens

Alignment Length:	189	Identity:	71/189 - (37%)
Similarity:	100/189 - (52%)	Gaps:	31/189 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SFARSQDKKCGICFETIMEK-EGGDKRFGILPSCNHVFCFQCICTWRHATQYAYQVTRACPECRV 154
            :|..||||.|.||.|.|:|| ...::|||||.:|||.:|..||..||.|.|:...:.::||||||
Human   229 AFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRV 293

  Fly   155 WSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFKQGQGVCLFGNKCFYKHSIPNADYVDVG 219
            .|.||.||.:|||::..|::||......|..:.||||:||:|.|.||:||.|:|:.|:....:..
Human   294 ISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPE 358

  Fly   220 LPTHALGLPIPSDFSGLGNCLILVPFPNMFFD-----DF---------SNSDDYDFSDV 264
            .|...|        |..|..        .||:     ||         .|::|.|.:::
Human   359 KPRKQL--------SSQGTV--------RFFNSVRLWDFIENRESRHVPNNEDVDMTEL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	25/54 (46%)
MKRN2	NP_054879.3	ZnF_C3H1	2..28	CDD:214632
		ZnF_C3H1	35..55	CDD:214632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142
		PHA03096	<178..327	CDD:222981	45/97 (46%)
		Makorin-type Cys-His	193..222
		RING	238..292	CDD:238093	25/53 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	0.172	Domainoid score	I8156
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880