DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and mkrn2

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_694511.1	Gene:	mkrn2 / 170783	ZFINID:	ZDB-GENE-020213-2	Length:	414	Species:	Danio rerio

Alignment Length:	223	Identity:	80/223 - (35%)
Similarity:	107/223 - (47%)	Gaps:	36/223 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PSSQIE--QKGNEAIVPNYKAATAGEQGEAQ--AGATCTTVAVRPSGVATSADIVKGS--SSVSS 82
            |.|.:|  :.|.:|...  .|||||...|.|  :...|..:|........|...:.|.  .....
Zfish   135 PHSYLEAIRSGLDASAA--AAATAGTFPELQQTSPQICPFLAAGQCQYGESCPYLHGEMCEICRQ 197

  Fly    83 HV----QPSWRS----------------SFA--RSQDKKCGICFETIMEKEG-GDKRFGILPSCN 124
            ||    .|..|:                :||  :||||.|.||.:.:.||.. .::|||||.||.
Zfish   198 HVLHPHDPEQRAAHEKKCMVAFEMDMERAFAVQQSQDKVCKICLDVVYEKSSPSERRFGILSSCA 262

  Fly   125 HVFCFQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCK 189
            |.:|..||..||...|...|:.::||||||.|.||.||.:|||::..|:.||.:..:.:..:.||
Zfish   263 HTYCLNCIRQWRCVEQLHNQIRKSCPECRVVSEFVIPSIYWVEDQEQKNLLIEEFKSGVSKKACK 327

  Fly   190 YFKQGQGVCLFGNKCFYKHSIPNADYVD 217
            ||.||:|.|.||.||||.|:     |.|
Zfish   328 YFDQGRGTCPFGGKCFYMHA-----YAD 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	23/54 (43%)
mkrn2	NP_694511.1	ZnF_C3H1	2..28	CDD:214632
		ZnF_C3H1	35..57	CDD:214632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..94
		PHA03096	<178..326	CDD:222981	49/147 (33%)
		Makorin-type Cys-His	192..221		4/28 (14%)
		RING	237..291	CDD:238093	23/53 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.980