DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12477 and mkrn1

DIOPT Version :9

Sequence 1:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_694510.1	Gene:	mkrn1 / 170782	ZFINID:	ZDB-GENE-020213-1	Length:	439	Species:	Danio rerio

Alignment Length:	178	Identity:	67/178 - (37%)
Similarity:	101/178 - (56%)	Gaps:	17/178 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GEAQAGATCTTV-----------AVRPSGVATSADIVKGSSSVSSHVQPSWRSSFA--RSQDKKC 100
            ||.:.|..|..:           .:.||..:..:..::  :.:.:| :.....|||  ||:|..|
Zfish   175 GECRYGLNCAYLHGDVCDMCGLQVLHPSDTSQRSQHIR--ACIEAH-EKDMEISFAIQRSKDMMC 236

  Fly   101 GICFETIMEKEG-GDKRFGILPSCNHVFCFQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAF 164
            |:|.|.:.||.. .::|||||.:|.|.:|.:||..||.|.|:..::.::|||||:.||||.||.:
Zfish   237 GVCMEVVFEKTNPSERRFGILSNCCHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEY 301

  Fly   165 WVEEKVAKDQLINDHLAAMRARDCKYFKQGQGVCLFGNKCFYKHSIPN 212
            |||:|..|.|||..:...|..:.|:||.:|:|.|.||..|||||:.|:
Zfish   302 WVEDKEEKQQLIQKYKDGMGTKPCRYFDEGRGTCPFGANCFYKHAFPD 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12477	NP_649055.1	RING	99..153	CDD:238093	23/54 (43%)
mkrn1	NP_694510.1	ZnF_C3H1	18..44	CDD:214632
		Torus	<52..84	CDD:292749
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..118
		PHA03096	<176..325	CDD:222981	52/151 (34%)
		Makorin-type Cys-His. /evidence=ECO:0000255	191..218		2/28 (7%)
		RING	235..290	CDD:238093	23/54 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..371
		MKRN1_C	357..437	CDD:292443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.880